Video 1
The patient at pre-DBS. There is multifocal myoclonus in the limbs and trunk at rest and with action. Asterixis and orthostatic myoclonus are also present.
Video 2
6-month post GPI-DBS. Marked reduction in rest and action myoclonus in the trunk and limbs. Gait improves with less assistance needed.
Figure 1
55sec of LFP spectrogram (y-axis represents frequency, 0–125 Hz and the color gradient is scaled from low power (Blue) to high LFP power (Red) normalized signal for a given time and frequency) and LFP power (LSB (analog to digital converter output)) from Left Gpi-DBS sensing electrode at 11–12 Hz and 50 Hz (top to bottom). The black solid line indicates stimulation current.
Table 1
UMRS from each clinic visit.
| MYOCLONUS AT REST | MYOCLONUS WITH ACTION | GLOBAL DISABILITY | NEGATIVE MYOCLONUS SCORE | NEGATIVE MYOCLONUS SEVERITY | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| R ARM | L ARM | R LEG | L LEG | ARISING | STANDING | WALKING | |||||
| Initial Programming | 18 | 16 | 16 | 16 | 12 | 16 | 12 | 12 | 4 | 1 | 3 |
| 1-month follow-up | 8 | 9 | 4 | 1 | 0 | — | — | 6 | 2 | 0 | 1 |
| 3-month follow-up | 22 | 9 | 6 | — | — | — | 6 | 12 | 2 | 1 | 2 |
| 6-month follow-up | 12 | 9 | 4 | 9 | 6 | — | 4 | 9 | 2 | 0 | 1 |
| %change: Baseline to 6-month | 33 | 44 | 75 | 44 | 50 | — | 67 | 25 | 50 | 100 | 66 |
Figure 2
Correlation of rest and action myoclonus component of UMRS with LFP activity at 11 Hz and 50 Hz.