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Lesioning Through a Directional Deep Brain Stimulation Lead in the Subthalamic Nucleus Cover

Lesioning Through a Directional Deep Brain Stimulation Lead in the Subthalamic Nucleus

Open Access
|Apr 2025

Figures & Tables

Table 1

Post-operative monopolar review. The thresholds for sensory and motor side effects are appropriate and suggest an adequate position within the STN.

LEFT LEADRIGHT LEAD
Contact 00.9 mA (hand dysesthesia, anxiety)1.4 mA (dysarthria)
Contact 11.4 mA (double vision and hand dysesthesia)1.4 mA (face and hand contraction)
Contact 22 mA (hemibody tingling)1.4 mA (face and hand contraction)
Contact 33 mA (hand and face contraction)1.5 mA (face and hand contraction)
Video 1

Intra-operative recording while creating a lesion. We show impedance monitoring, neurological testing, and finalization of the lesion.

tohm-15-1-993-g1.png
Figure 1

Directional DBS lead diagram (A). When the lead is “unraveled” it has a total of 8 contacts – two monopolar levels and 2 levels with 3 segments each (B). At the proximal end of the lead, where it would normally connect to the extension cable (C.) the 8 contacts are now split into 8 sequential contacts. This is where the alligator clips (represented by white trapezoids) of the radiofrequency ablation device connect for the lesioning procedure (D). Note that each alligator clip covered two contacts due to its width (e.g. 1A and 1B, or 2B and 2C).

tohm-15-1-993-g2.png
Figure 2

A graphical representation of the radiofrequency ablation procedure is demonstrated through a segmented lead. Left panel: a test lesion was made stimulating from contact segments 1A and 1B, followed by 1B and 1C. Middle panel: since there were no neurological deficits after the test lesion, we began to shape the permanent lesion. We set the stimulation at a higher amplitude in different combinations of segment pairs to cover the tissue surrounding contacts 1 and 2. Right panel: The final lesion spans the area surrounding all segments comprising contacts 1 and 2.

tohm-15-1-993-g3.png
Figure 3

Axial sections of a brain MRI FLAIR sequence showing the lesion one-month post-procedure. The lesion can be seen on the left hemisphere as a hyperintense signal in the subthalamic region (green arrow heads).

DOI: https://doi.org/10.5334/tohm.993 | Journal eISSN: 2160-8288
Language: English
Submitted on: Jan 3, 2025
Accepted on: Mar 17, 2025
Published on: Apr 7, 2025
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2025 Alfonso Enrique Martinez Nunez, Dorian M. Kusyk, Joshua K. Wong, Michael S. Okun, Justin D. Hilliard, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.