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High Intensity Focused Ultrasound – Longitudinal Data on Efficacy and Safety Cover

High Intensity Focused Ultrasound – Longitudinal Data on Efficacy and Safety

Open Access
|May 2025

References

  1. 1Chang WS, Jung HH, Zadicario E, Rachmilevitch I, Tlusty T, Vitek S, Chang JW. Factors associated with successful magnetic resonance-guided focused ultrasound treatment: efficiency of acoustic energy delivery through the skull. J Neurosurg. 2016 Feb;124(2):4116. DOI: 10.3171/2015.3.JNS142592
  2. 2Boutet A, Gwun D, Gramer R, Ranjan M, Elias GJB, Tilden D, Huang Y, Li SX, Davidson B, Lu H, Tyrrell P, Jones RM, Fasano A, Hynynen K, Kucharczyk W, Schwartz ML, Lozano AM. The relevance of skull density ratio in selecting candidates for transcranial MR-guided focused ultrasound. J Neurosurg. 2019 May 3;132(6):17851791. DOI: 10.3171/2019.2.JNS182571
  3. 3Vetkas A, Boutet A, Sarica C, Germann J, Gwun D, Yamamoto K, Jung HH, Alkhotani A, Samuel N, Lang S, Conner CR, Elias GJB, Cheyuo C, Chow C, Santyr B, Iorio-Morin C, Yang AZ, Candeias da Silva C, Fasano A, Kalia SK, Lozano AM. Successful magnetic resonance-guided focused ultrasound treatment of tremor in patients with a skull density ratio of 0.4 or less. J Neurosurg. 2023 Sep 1;140(3):639647. DOI: 10.3171/2023.6.JNS23171
  4. 4Elias WJ, Lipsman N, Ondo WG, Ghanouni P, Kim YG, Lee W, Schwartz M, Hynynen K, Lozano AM, Shah BB, Huss D, Dallapiazza RF, Gwinn R, Witt J, Ro S, Eisenberg HM, Fishman PS, Gandhi D, Halpern CH, Chuang R, Butts Pauly K, Tierney TS, Hayes MT, Cosgrove GR, Yamaguchi T, Abe K, Taira T, Chang JW. A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor. N Engl J Med. 2016 Aug 25;375(8):7309. DOI: 10.1056/NEJMoa1600159
  5. 5Elias WJ, Huss D, Voss T, Loomba J, Khaled M, Zadicario E, et al. A pilot study of focused ultrasound thalamotomy for essential tremor. N Engl J Med. 2013;369(7):6408. DOI: 10.1056/NEJMoa1300962
  6. 6Chang JW, Park CK, Lipsman N, Schwartz ML, Ghanouni P, Henderson JM, Gwinn R, Witt J, Tierney TS, Cosgrove GR, Shah BB, Abe K, Taira T, Lozano AM, Eisenberg HM, Fishman PS, Elias WJ. A prospective trial of magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: Results at the 2-year follow-up. Ann Neurol. 2018 Jan;83(1):107114. DOI: 10.1002/ana.25126
  7. 7Halpern CH, Santini V, Lipsman N, Lozano AM, Schwartz ML, Shah BB, Elias WJ, Cosgrove GR, Hayes MT, McDannold N, Aldrich C, Eisenberg HM, Gandhi D, Taira T, Gwinn R, Ro S, Witt J, Jung NY, Chang JW, Rosenberg J, Ghanouni P. Three-year follow-up of prospective trial of focused ultrasound thalamotomy for essential tremor. Neurology. 2019 Dec 10;93(24):e2284e2293. DOI: 10.1212/WNL.0000000000008561
  8. 8Park YS, Jung NY, Na YC, Chang JW. Four-year follow-up results of magnetic resonance-guided focused ultrasound thalamotomy for essential tremor. Mov Disord. 2019;34(5):72734. DOI: 10.1002/mds.27637
  9. 9Zur G, Lesman-Segev OH, Schlesinger I, Goldsher D, Sinai A, Zaaroor M, Assaf Y, Eran A, Kahn I. Tremor Relief and Structural Integrity after MRI-guided Focused US Thalamotomy in Tremor Disorders. Radiology. 2020 Mar;294(3):676685. DOI: 10.1148/radiol.2019191624
  10. 10Wu P, Lin W, Li KH, Lai HC, Lee MT, Tsai KW, Chiu PY, Chang WC, Wei CY, Taira T. Focused Ultrasound Thalamotomy for the Treatment of Essential Tremor: A 2-Year Outcome Study of Chinese People. Front Aging Neurosci. 2021 Jul 14;13:697029. DOI: 10.3389/fnagi.2021.697029
  11. 11Fukutome K, Kuga Y, Ohnishi H, Hirabayashi H, Nakase H. What factors impact the clinical outcome of magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor? J Neurosurg. 2020 May 1;134(5):16181623. DOI: 10.3171/2020.2.JNS192814
  12. 12Purrer V, Borger V, Pohl E, Upadhyay N, Boecker H, Schmeel C, Pieper CC, Wüllner U. Transcranial high-intensity Magnetic Resonance-guided focused ultrasound (tcMRgFUS) – safety and impacts on tremor severity and quality of life. Parkinsonism Relat Disord. 2022 Jul;100:612. DOI: 10.1016/j.parkreldis.2022.05.017
  13. 13Cosgrove GR, Lipsman N, Lozano AM, Chang JW, Halpern C, Ghanouni P, Eisenberg H, Fishman P, Taira T, Schwartz ML, McDannold N, Hayes M, Ro S, Shah B, Gwinn R, Santini VE, Hynynen K, Elias WJ. Magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results. J Neurosurg. 2022 Aug 5;138(4):10281033. DOI: 10.3171/2022.6.JNS212483
  14. 14Alshaikh J, Fishman PS. Revisiting bilateral thalamotomy for tremor. Clin Neurol Neurosurg. 2017 Jul;158:103107. DOI: 10.1016/j.clineuro.2017.04.025
  15. 15Ito H, Yamamoto K, Fukutake S, Odo T, Yamaguchi T, Taira T. Magnetic resonance imaging-guided focused ultrasound bilateral thalamotomy for essential tremor: A case report. Neurol Clin Neurosci. 2020;8:412414. DOI: 10.1111/ncn3.12438
  16. 16Iorio-Morin C, Yamamoto K, Sarica C, Zemmar A, Levesque M, Brisebois S, Germann J, Loh A, Boutet A, Elias GJB, Azevedo P, Adam E, Patel U, Lenis M, Kalia SK, Hodaie M, Fasano A, Lozano AM. Bilateral Focused Ultrasound Thalamotomy for Essential Tremor (BEST-FUS Phase 2 Trial). Mov Disord. 2021 Nov;36(11):26532662. DOI: 10.1002/mds.28716
  17. 17Fukutome K, Hirabayashi H, Osakada Y, Kuga Y, Ohnishi H. Bilateral Magnetic Resonance Imaging-Guided Focused Ultrasound Thalamotomy for Essential Tremor. Stereotact Funct Neurosurg. 2022;100(1):4452. DOI: 10.1159/000518662
  18. 18Martínez-Fernández R, Mahendran S, Pineda-Pardo JA, Imbach LL, Máñez-Miró JU, Büchele F, Del Álamo M, Rodriguez-Rojas R, Hernández-Fernández F, Werner B, Matarazzo M, Obeso I, Gonzalez-Quarante LH, Deuschl G, Stieglitz L, Baumann CR, Obeso JA. Bilateral staged magnetic resonance-guided focused ultrasound thalamotomy for the treatment of essential tremor: a case series study. J Neurol Neurosurg Psychiatry. 2021 Sep;92(9):927931. DOI: 10.1136/jnnp-2020-325278
  19. 19Scantlebury N, Rohringer CR, Rabin JS, Yunusova Y, Huang Y, Jones RM, Meng Y, Hamani C, McKinlay S, Gopinath G, Sewell IJ, Marzouqah R, McSweeney M, Lam B, Hynynen K, Schwartz ML, Lipsman N, Abrahao A. Safety of Bilateral Staged Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor. Mov Disord Clin Pract. 2023 Sep 15;10(10):15591561. DOI: 10.1002/mdc3.13882
  20. 20Bond AE, Shah BB, Huss DS, Dallapiazza RF, Warren A, Harrison MB, Sperling SA, Wang XQ, Gwinn R, Witt J, Ro S, Elias WJ. Safety and Efficacy of Focused Ultrasound Thalamotomy for Patients With Medication-Refractory, Tremor-Dominant Parkinson Disease: A Randomized Clinical Trial. JAMA Neurol. 2017 Dec 1;74(12):14121418. DOI: 10.1001/jamaneurol.2017.3098
  21. 21Yamamoto K, Ito H, Fukutake S, Odo T, Kamei T, Yamaguchi T, Taira T. Focused Ultrasound Thalamotomy for Tremor-dominant Parkinson’s Disease: A Prospective 1-year Follow-up Study. Neurol Med Chir (Tokyo). 2021 Jul 15;61(7):414421. DOI: 10.2176/nmc.oa.2020-0370
  22. 22Jung NY, Park CK, Kim M, Lee PH, Sohn YH, Chang JW. The efficacy and limits of magnetic resonance-guided focused ultrasound pallidotomy for Parkinson’s disease: a Phase I clinical trial. J Neurosurg. 2018 Aug 1:19. DOI: 10.3171/2018.2.JNS172514
  23. 23Ito H, Yamamoto K, Fukutake S, Kamei T, Yamaguchi T, Taira T. Two-year follow-up results of magnetic resonance imaging-guided focused ultrasound unilateral pallidotomy for Parkinson’s disease. Neurol Clin Neurosci. 2021;9:7376. DOI: 10.1111/ncn3.12455
  24. 24Eisenberg HM, Krishna V, Elias WJ, Cosgrove GR, Gandhi D, Aldrich CE, Fishman PS. MR-guided focused ultrasound pallidotomy for Parkinson’s disease: safety and feasibility. J Neurosurg. 2020 Nov 27;135(3):792798. DOI: 10.3171/2020.6.JNS192773
  25. 25Martínez-Fernández R, Rodríguez-Rojas R, Del Álamo M, Hernández-Fernández F, Pineda-Pardo JA, Dileone M, Alonso-Frech F, Foffani G, Obeso I, Gasca-Salas C, de Luis-Pastor E, Vela L, Obeso JA. Focused ultrasound subthalamotomy in patients with asymmetric Parkinson’s disease: a pilot study. Lancet Neurol. 2018 Jan;17(1):5463. DOI: 10.1016/S1474-4422(17)30403-9
  26. 26Martínez-Fernández R, Máñez-Miró JU, Rodríguez-Rojas R, Del Álamo M, Shah BB, Hernández-Fernández F, Pineda-Pardo JA, Monje MHG, Fernández-Rodríguez B, Sperling SA, Mata-Marín D, Guida P, Alonso-Frech F, Obeso I, Gasca-Salas C, Vela-Desojo L, Elias WJ, Obeso JA. Randomized Trial of Focused Ultrasound Subthalamotomy for Parkinson’s Disease. N Engl J Med. 2020 Dec 24;383(26):25012513. DOI: 10.1056/NEJMoa2016311
  27. 27Peters J, Maamary J, Kyle K, Olsen N, Jones L, Bolitho S, Barnett Y, Jonker B, Tisch S. Outcomes of Focused Ultrasound Thalamotomy in Tremor Syndromes. Mov Disord. 2024 Jan;39(1):173182. DOI: 10.1002/mds.29658
  28. 28Gallay MN, Moser D, Magara AE, Haufler F, Jeanmonod D. Bilateral MR-Guided Focused Ultrasound Pallidothalamic Tractotomy for Parkinson’s Disease With 1-Year Follow-Up. Front Neurol. 2021 Feb 9;12:601153. DOI: 10.3389/fneur.2021.601153
  29. 29Jackson LM, Kaufmann TJ, Lehman VT, Lee KH, Miller KJ, Hassan A, Klassen BT. Clinical Characteristics of Patients with Gait Instability after MR-Guided Focused Ultrasound Thalamotomy. Tremor Other Hyperkinet Mov (N Y). 2021 Oct 21;11:41. DOI: 10.5334/tohm.643
  30. 30Giordano M, Caccavella VM, Zaed I, Foglia Manzillo L, Montano N, Olivi A, Polli FM. Comparison between deep brain stimulation and magnetic resonance-guided focused ultrasound in the treatment of essential tremor: a systematic review and pooled analysis of functional outcomes. J Neurol Neurosurg Psychiatry. 2020 Dec;91(12):12701278. DOI: 10.1136/jnnp-2020-323216
  31. 31Harary M, Segar DJ, Hayes MT, Cosgrove GR. Unilateral Thalamic Deep Brain Stimulation Versus Focused Ultrasound Thalamotomy for Essential Tremor. World Neurosurg. 2019 Jun;126:e144e152. DOI: 10.1016/j.wneu.2019.01.281
  32. 32Wider C, Pollo C, Bloch J, Burkhard PR, Vingerhoets FJ. Long-term outcome of 50 consecutive Parkinson’s disease patients treated with subthalamic deep brain stimulation. Parkinsonism Relat Disord. 2008;14(2):1149. DOI: 10.1016/j.parkreldis.2007.06.012
  33. 33Toft M, Lilleeng B, Ramm-Pettersen J, Skogseid IM, Gundersen V, Gerdts R, Pedersen L, Skjelland M, Røste GK, Dietrichs E. Long-term efficacy and mortality in Parkinson’s disease patients treated with subthalamic stimulation. Mov Disord. 2011 Aug 15;26(10):19314. DOI: 10.1002/mds.23817
  34. 34Hanna JA, Scullen T, Kahn L, Mathkour M, Gouveia EE, Garces, J, Evans LM, Lea G, Houghton DJ, Biro E, Bui CJ, Sulaiman OA, Smith RD. Comparison of elderly and young patient populations treated with deep brain stimulation for Parkinson’s disease: long-term outcomes with up to 7 years of follow-up. Journal of Neurosurgery JNS. 2019;131(3):807812. DOI: 10.3171/2018.4.JNS171909
  35. 35Tiefenbach J, Favi Bocca L, Hogue O, Nero N, Baker KB, Machado AG. Intracranial Bleeding in Deep Brain Stimulation Surgery: A Systematic Review and Meta-Analysis. Stereotact Funct Neurosurg. 2023;101(3):207216. DOI: 10.1159/000530398
  36. 36Topp G, Ghulam-Jelani Z, Chockalingam A, Kumar V, Byraju K, Sukul V, Pilitsis JG. Safety of Deep Brain Stimulation Lead Placement on Patients Requiring Anticlotting Therapies. World Neurosurg. 2021 Jan;145:e320e325. DOI: 10.1016/j.wneu.2020.10.047
  37. 37Wakim AA, Mattar JB, Lambert M, Ponce FA. Perioperative complications of deep brain stimulation among patients with advanced age: a single-institution retrospective analysis. J Neurosurg. 2021 Feb 12;135(5):14211428. DOI: 10.3171/2020.8.JNS201283
  38. 38Rocha S, Monteiro A, Linhares P, Chamadoira C, Basto MA, Reis C, Sousa C, Lima J, Rosas MJ, Massano J, Vaz R. Long-term mortality analysis in Parkinson’s disease treated with deep brain stimulation. Parkinsons Dis. 2014;2014:717041. DOI: 10.1155/2014/717041
  39. 39Rothlind JC, York MK, Luo P, Carlson K, Marks, WJ Jr, Weaver FM, Stern M, Follett KA, Duda JE, Reda DJ. CSP-468 study group. Predictors of multi-domain cognitive decline following DBS for treatment of Parkinson’s disease. Parkinsonism Relat Disord. 2022 Feb;95:2327. DOI: 10.1016/j.parkreldis.2021.12.011
  40. 40Saporito G, Sucapane P, Bruno F, Catalucci A, Masciocchi C, Pistoia ML, Splendiani A, Ricci A, Di Cesare E, Marini C, Mazza M, Totaro R, Pistoia F. Cognitive safety of focused ultrasound thalamotomy for tremor: 1-year follow-up results of the COGNIFUS part 2 study. Front Neurol. 2024 Jun 17;15:1395282. DOI: 10.3389/fneur.2024.1395282
DOI: https://doi.org/10.5334/tohm.987 | Journal eISSN: 2160-8288
Language: English
Submitted on: Jan 16, 2025
Accepted on: Apr 17, 2025
Published on: May 5, 2025
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2025 Betsy Thomas, Gabriele Bellini, Wen-Yu Lee, Yidan Shi, Alon Mogilner, Michael H. Pourfar, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.