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Patient Selection for Deep Brain Stimulation for Pantothenate Kinase-Associated Neurodegeneration Cover

Patient Selection for Deep Brain Stimulation for Pantothenate Kinase-Associated Neurodegeneration

Open Access
|Oct 2024

Figures & Tables

Video 1

Pre- and post-DBS examination. Presurgical baseline examination at 23 years of age and postsurgical gait 15 months after bilateral GPi DBS implantation. Laryngeal dystonia was present with speech. Dystonia was most prominent when walking and impaired her gait. Retrocollis, opisthotonus, right upper extremity flexion, and bilateral plantar flexion were present. DBS improved her dystonia and gait.

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Figure 1

Axial (left) and coronal (right) T2-FLAIR brain MRI showed bilateral hypointensity of the globus pallidus with anterior medial hyperintensity, consistent with the “eye of the tiger” sign. L = left.

tohm-14-1-929-g2.png
Figure 2

Lead localizations in the right (blue) and left (purple) globus pallidus internus (GPi) (orange), viewed from the lateral and anterior perspectives. Lead localization was performed using Brainlab Elements (Brainlab AG, Munich, Germany). Leads were implanted targeting the posteroventral GPi.

DOI: https://doi.org/10.5334/tohm.929 | Journal eISSN: 2160-8288
Language: English
Submitted on: Jun 15, 2024
Accepted on: Oct 10, 2024
Published on: Oct 17, 2024
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2024 Jason L. Chan, Ashley E. Rawls, Joshua K. Wong, Penelope Hogarth, Justin D. Hilliard, Michael S. Okun, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.