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Clinical Assessment of the Effect of Tetrabenazine on Functional Scales in Huntington Disease: A Pilot Open Label Study Cover

Clinical Assessment of the Effect of Tetrabenazine on Functional Scales in Huntington Disease: A Pilot Open Label Study

Open Access
|Aug 2012

Figures & Tables

Table 1.

Study Results

VariableOn/OffMean (±SD)95% CIz1Probability >|z|
MoCA (total)Off19.95 (5.56)16.8–23.2
On20.0 (4.50)17.4–22.60.5310.595
Dynamic Gait Index (total)Off14.4 (7.01)9.38–19.42
On17.5 (6.9412.53–22.472.0450.0412
Berg Balance Scale (total)Off40.9 (9.67)33.99–47.81
On46.5 (6.06)42.17–50.832.680.0072
Jebsen Hand Test (total) (non-dominant)Off193.1 (111.6)113.2–272.9
On217.3 (111.3)137.7–296.91.0700.285
Jebsen Hand Test (total) (dominant)Off131.2 (73.3)78.8–183.6
On125.0 (57.1)84.1–165.8−0.4590.647
Timed 25-foot Walk (average, two trials)Off8.5 (3.6)5.9–11.1
On8.1 (2.1)6.6–9.5.01530.879
Beck Depression Inventory II (total)Off12.8 (9.7)5.9–19.7
On10.4 (6.7)5.6–15.2−1.4360.151
QuickDASH (disability/symptom score)Off43.2 (27.5)23.5–62.8
On37.3 (26.5)18.3–56.2−1.020.307
UHDRS-1 Motor (total motor score)Off45.4 (10.4)38.0–52.8
On36.1 (15.7)24.9–47.3−2.6090.0092
UHDRS-1 Motor (max chorea)Off18.4 (2.5)16.6–20.2
On10.8 (5.5)6.9–14.7−2.8140.0052
UHDRS-1 Motor total motor – max choreaOff27.0 (9.9)19.9–34.1
On25.3 (12.4)16.5–34.1−0.8730.383
UHDRS-2 Cognition: Stroop Color-Word26Off7.72 (7.5).67–12.5
On14.3 (3.6)11.5–17.12.1910.0282
UHDRS-3 Behavior: Frequency and SeverityOff9.3 (10.5)4.5–22.3
On13.4 (12.5)1.8–16.81.2980.194
UHDRS-4 Functional ChecklistOff15.2 (5.3)11.4–19.0
On17.0 (5.0)13.4–20.61.0270.304
UHDRS-5 Independence ScaleOff67.0(10.3)59.6–74.4
On74.5(13.0)65.2–83.80.0623

1 Wilcoxon matched-pairs signed-rank test.

2 Statistically significant result.

3 Two tailed paired Student's t-test.

Abbreviations: CI, confidence interval; MoCA, Montreal Cognitive Assessment; SD, standard deviation; UHDRS, Unified Huntington Disease Rating Scale.

DOI: https://doi.org/10.5334/tohm.91 | Journal eISSN: 2160-8288
Language: English
Submitted on: Dec 29, 2011
Accepted on: Oct 14, 2012
Published on: Aug 6, 2012
Published by: Columbia University Libraries/Information Services
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2012 Robert Fekete, Anthony Davidson, Joseph Jankovic, published by Columbia University Libraries/Information Services
This work is licensed under the Creative Commons License.