Figure 1
PRISMA flow diagram of the study depicts the procedure of selecting articles for the systematic review.
Table 1
Summary of epidemiological, clinical features, neuroimaging findings, histopathological features and outcome of patients of SSPE with various movement disorder (n = 39).
| Age (in years) | Mean = 13.8 |
| Median = 14 | |
| Range = 4–63 | |
| Interquartile Range = 10 | |
| Sex | Female = 13 (33.3%) |
| Male = 26 (66.7%) | |
| Measles vaccination | Yes = 8 (20.5%) |
| No/NA = 31(79.5%) | |
| Childhood measles | Yes = 15 (38.5%) |
| No or NA = 24 (61.5%) | |
| Geographical areas of reported cases (total 37 reports) | India = 23 (62.2%) |
| Other country in Asia = 1 (2.7%) | |
| Europe, except Turkey = 3 (8.1%) | |
| Turkey = 5 (13.5%) | |
| American continent = 4 (10.8%) | |
| Australia = 1 (2.7%) | |
| Duration of illness | Sudden = 2 (5.2%) |
| Within a week = 3 (7.8%) | |
| >1week up to 1 month = 8 (20.5%) | |
| >1 month to 6 months = 15 (38.5%) | |
| >6 months = 9 (23.7%) | |
| NA = 2 (5.2%) | |
| Course of the disease | Acute fulminant = 25 (64%) |
| Chronic = 11 (28.2%) | |
| NA = 3 (7.8%) | |
| Movement disorder other than periodic myoclonus | Dystonia = 19 (48.7%) |
| PISA syndrome = 3 (7.8%) | |
| Generalised = 11 (28.2%) | |
| Focal = 3 (7.8%) | |
| Hemidystonia = 2 (5.2%) | |
| Parkinsonism/hemi-parkinsonism = 8 (20.5%) | |
| Choreo-athetosis = 5 (12.8%) | |
| Chorea = 2 (5.2%) | |
| Tics = 2 (5.2%) | |
| Focal myoclonus = 1 (2.6%) | |
| Tremors and hyperkinesia = 1(2.6%) | |
| Neuroleptic malignant syndrome = 1(2.6%) | |
| Neuroimaging | NA = 1(2.6%) |
| Normal = 10 (25.6%) | |
| T2/FLAIR hyperintensity = 28 (71.8%) | |
| Basal ganglion = 8 (20.5%) | |
| Brain stem = 3(7.8%) | |
| Corpus callosum = 2 (5.2%) | |
| Thalamus = 2 (5.2%) | |
| Periventricular = 21 (53.8%) | |
| Whole frontal lobe =1 (2.6%) | |
| Cystic lesion = 1 (2.6%) | |
| Brain biopsy | NA = 36 (92.3%) |
| Done = 3 (7.8%) | |
| Outcome | Deteriorated/ died = 22 (56.4%) |
| Survived/ Improved = 8 (20.5%) | |
| NA = 9 (23.7%) |
[i] NA = not available; FLAIR = Fluid attenuated inversion recovery.