Video Segment 1
Wilson’s disease patient before treatment with penicillamine. The patient exhibited a severe bilateral wing-beating tremor, moderate head and lower limb tremors, and mild cervical dystonia.
Figure
Left: Wilson’s disease brain MRI before treatment. MRI shows T2-hyperintensity in the midbrain tegmentum (red arrows in A1), pontine tectum (red arrow in B1), and dentato-rubro-thalamic tract (red arrows in D1). SWI reveals hypointensity and atrophy in the lentiform and caudate nuclei (red circles in C1). Right: Brain MRI post 3-year penicillamine (A2–D2). Marked improvement in T2 hyperintense lesions.
Video Segment 2
Wilson’s disease patient follow-up after treatment with penicillamine. Substantial improvement in symptoms was observed over the three-year follow-up period after penicillamine treatment.