Video 1
Video shows the clinical features of the patient with MAPT mutation. Showing (A) slowing or horizontal and vertical saccades. (B) asymmetric rest tremor of upper and lower limbs with re-emergence and position specificity, and mild right-sided bradykinesia of upper and lower limbs. (C) Worsening of tremor when pouring water between two cups. (written consent was obtained from the patients for the video to be submitted/published if accepted in this journal).
Figure 1
Serial coronal magnetic resonance fluid attenuated inversion recovery images taken at different time points relative to the clinical presentation. A, C, E show anterior frontotemporal regions and B, D, F show mesial temporal structures. Progressive atrophy of anterior temporal (arrow) and mesial temporal lobe structures (arrowhead) is demonstrated. Left frontal lobe changes secondary to meningioma surgery are also seen.
Figure 2
A: Sagittal T2-weighted magnetic resonance imaging taken at the time of clinical presentation shows no evidence of hummingbird sign. B: Axial T1-weighted MR at the same time point does not show midbrain atrophy, anteroposterior midbrain diameter = 15 mm.