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Progressive Multifocal Encephalopathy Holmes Tremor Successfully Treated with Bilateral Deep Brain Stimulation Cover

Progressive Multifocal Encephalopathy Holmes Tremor Successfully Treated with Bilateral Deep Brain Stimulation

Open Access
|Sep 2023

Figures & Tables

tohm-13-1-781-g1.png
Figure 1

MRI brain. Preoperative MRI revealing late sequela of demyelination with brain atrophy and pathy areas of secondary axonal loss throughout the brain and concavity of the apex of the midbrain.

Table 1

Fahn, Tolosa, Marin Tremor Rating scale with the deep brain stimulation turned on and off.

OFF STIMON STIMON ADJUSTED STIM
RESTPOSTACTIONRESTPOSTACTIONRESTPOSTACTION
1. Face1000
2. Tongue000000
3. Voice111
4. Head000000
5. RUE233122122
6. LUE344133133
7. Trunk000000
8. RLE000000000
9. LLE000000000
Total578––256
RIGHTLEFTN/ARIGHTLEFTN/ARIGHTLEFTN/A
10. Handwriting243
11. Drawing A34423
12. Drawing B4423
13. Drawing C4423
14. Pouring4443434
15. Speaking522
16. Feeding other than liquids642
17. Bringing liquids to mouth43
18. Hygiene44
19. Dressing43
20. Writing43
21. Working743
Total16163091323
Overall Total Score8258

[i] 1Definitions for 1–9: 0 = none; 1 = slight; 2 = moderate amplitude; 3 – marked amplitude; 4 = severe amplitude; 2Definitons for 10: 0 = normal; 1 = mildly abnormal; 2 = moderately abnormal; 3 = marked abnormal; 4 = severely abnormal; 3Definitions for 11–13: 0 = normal; 1 = slightly tremulous; 2 = moderately tremulous; 3 = accomplishes the task with great difficulty; 4 = unable to complete; 4Pouring: 0 = normal; 1 = more careful than a person without tremor; 2 = spills a small amount; 3 = spills a considerable amount; 4 = unable to pour water; 5Speaking: 0 = normal; 1 = mild voice tremulousness when “nervous” only; 2 = mild voice tremor, constant; 3 = moderate; 4 = severe, some words are difficult to understand; 6Definition 16–20: 0 = normal 1 = mildly normal; 2 = moderately abnormal; 3 = markedly abnormal; 4 = severely abnormal; 7Working: 0 = tremor does not interfere with job; 1 = able to work, but needs to be more careful than the average person; 2 = able to do everything, but with errors; 3 = unable to do regular job. May have changed to a different job because of tremor; 4 = Unable to do any outside job.

tohm-13-1-781-g2.png
Figure 2

Fahn-Tolosa-Marin rating scale of tremor Drawings A, B and C. Drawings with stimulation on, using left hand (left) and right hand (right). Drawings with the stimulation off are not shown because the patient was not able to perform either task.

DOI: https://doi.org/10.5334/tohm.781 | Journal eISSN: 2160-8288
Language: English
Submitted on: Jun 3, 2023
Accepted on: Aug 19, 2023
Published on: Sep 1, 2023
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2023 Talita D. Rosa, Laura Dixon, Muhammad Ismail Khalid Yousaf, Victoria Holiday, Ajmal Zemmar, Joseph Neimat, Peter Hedera, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.