Figure 1
PRISMA diagram illustrating the study retrieval process.
Table 1
Characteristics of included studies.
| AUTHOR/YEAR | SETTING | TOTAL NUMBER OF CASES | AGE GROUP IN YEARS (MEAN± S.D) | GENDER RATIO (F:M) | MS PATTERN | DURATION OF MS IN YEARS, MEAN (SD) | MEDIAN EDSS | TREMOR PREVALENCE | SEVERE TREMOR PREVALENCE | TYPE OF TREMOR (% OF TOTAL NUMBER OF CASES) |
|---|---|---|---|---|---|---|---|---|---|---|
| Alusi/2001 [8] | Cross-sectional | 100 | 47.2 ± 10.3 | 1.86 | SPMS (63%) PPMS (22%) RRMS (15%) | 18.8 | 6.0 (range 0–9) | 58% | 15% | Postural (44%) Intention (6%) |
| Pittock/2004 [11] | Community- based cohort | 200 | 35 ± 12.4 | 2.3 | RRMS (65%) SPMS (30%) PPMS (5%) | Tremor group 21.9± 12.4; No tremor group 20.4 ± 12.9 | 3.0 (range 0–9.5) | 25% | 3% | NA |
| Gines/2013 [10] | Cross-sectional | 50 | 45.6 ± 10.8 | 2.33 | RRMS (66%) SPMS (16%) PPMS (6%) CIS (12%) | NA | NA | 30% | NA | Postural (20%) Intentional (20%), Simple kinetic (6%) Mixed postural and action (12%) |
| Soto/2013 [14] | Cross-sectional | 192 | NA | NA | NA | NA | NA | 53% | NA | Action tremor |
| Rinker/2015 [12] | Cross-sectional | 552 | NA | 3.54 | RRMS (48.9%) | 17.1 ± 8.4 | NA | 45–46.8% | 5.5–5.9% | NA |
| Walt/2015 [13] | Case control study | 27 | 50 ± 10.8 | 1.11 | SPMS (74%) RRMS (26%) | 17 ± 8.2 | 5.5 (S.D. = 4. 6) | NA | 33% | NA |
| Silva/2017 [17] | Cross-sectional | 208 | NA | NA | NA | NA | NA | 12.5% | NA | Intention (10.25%) |
| Salari/2018 [9] | Cross-sectional | 164 | 36.35 ± 9.357 | 4.125 | RRMS (59.3%) SPMS (33.6%) PPMS (7.1%) | NA | 2.732 (SD = 1.78) | 68.9% | 14% | Action (41.6%) Resting (30.5%) Intention (43.9%) |
| Abboud/2019 [7] | Prospective observational study | 60 | 38.3 ± 12.7 | 1.3 | RRMS (63.3%) | 11.4 ± 18.2 | NA | 41.6% | NA | Action hand (41.67%) Resting (5%) Rubral (3.3%) |