Table 1
Demographic and Clinical Characteristics as a Function of MAPT Haplotype.
| MAPT HAPLOTYPEa | |||
|---|---|---|---|
| H1/H1 | NON-H1/H1 | p | |
| N | 57 | 42 | – |
| Baseline age (years) | 77.9 ± 7.6 | 76.6 ± 9.9 | 0.43b |
| Sex (female) | 32 (56.1) | 28 (66.7) | 0.29c |
| Race (Caucasian) | 57 (100.0) | 42 (100.0) | – |
| Education (years) | 16.4 ± 2.4 | 15.1 ± 2.4 | 0.02 b |
| Age of tremor onset (years) | 39.1 ± 20.9 | 35.8 ± 22.0 | 0.46d |
| Tremor duratione (years) | 38.5 ± 21.7 | 40.5 ± 21.3 | 0.66b |
| Cognitive diagnosisf | |||
| Normal cognition | 45 (80.4) | 32 (76.2) | 0.87c |
| MCI | 4 (7.1) | 4 (9.5) | |
| Dementia | 7 (12.5) | 6 (14.3) | |
| Age at conversion to MCI (years) | 83.1 ± 5.6 | 82.3 ± 11.5 | 0.84b |
| Age at conversion to dementia (years) | 89.1 ± 7.8 | 88.5 ± 6.5 | 0.88b |
| Time elapsed from tremor onset to conversion to MCI (years)g | 40.2 ± 24.3 | 46.8 ± 20.5 | 0.51b |
| Time elapsed from tremor onset to conversion to dementia (years)h | 48.5 ± 26.0 | 51.2 ± 22.9 | 0.86b |
[i] Note: Sample N = 99. MCI = mild cognitive impairment. Degrees of freedom for specific measures may vary slightly due to missing data. Values indicate means ± standard deviation or N (percentages).
a H1/H1 haplotype n = 57; non-H1/H1 haplotype n = 42.
b Student’s t-test.
c Chi square test.
d Mann-Whitney test.
e Baseline age minus tremor onset age.
f Diagnostic classification at final evaluation.
g Age at conversion to MCI minus age of tremor onset.
h Age at conversion to dementia minus age of tremor onset.
Table 2
Cognitive Performance as a Function of MAPT Haplotype and Time: Repeated Measures Analyses of Covariance.
| DEPENDENT | MAPT | EVALUATION (TIME) MEAN | MAPTb | TIMEc | INTERACTIONd | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| VARIABLE | HAPLOTYPEa | 1 | 2 | 3 | 4 | F | p | F | p | F | p |
| Attention | H1/H1 | –0.17 | –0.06 | –0.22 | –0.39 | 0.55 | 0.46 | 5.18 | 0.002 | 0.33 | 0.80 |
| Non-H1/H1 | –0.26 | –0.18 | –0.25 | –0.36 | |||||||
| Total sample | –0.21 | –0.11 | –0.23 | –0.38 | |||||||
| Executive Function | H1/H1 | –0.12 | –0.09 | –0.17 | –0.31 | 0.09 | 0.76 | 1.71 | 0.16 | 2.53 | 0.06 |
| Non-H1/H1 | –0.25 | –0.18 | –0.18 | –0.20 | |||||||
| Total sample | –0.17 | –0.13 | –0.18 | –0.26 | |||||||
| Language | H1/H1 | –0.16 | 0.08 | 0.03 | –0.15 | 2.41 | 0.12 | 2.27 | 0.08 | 0.13 | 0.94 |
| Non-H1/H1 | –0.34 | –0.12 | –0.04 | –0.33 | |||||||
| Total sample | –0.24 | –0.01 | –0.01 | –0.23 | |||||||
| Memory | H1/H1 | –0.11 | –0.14 | 0.10 | –0.13 | 1.05 | 0.31 | 2.68 | 0.05 | 1.48 | 0.23 |
| Non-H1/H1 | –0.22 | –0.23 | –0.14 | –0.09 | |||||||
| Total sample | –0.16 | –0.18 | 0.01 | –0.11 | |||||||
| Visuospatial | H1/H1 | –0.10 | 0.04 | –0.18 | –0.28 | 0.38 | 0.54 | 4.41 | 0.005 | 0.83 | 0.48 |
| Non-H1/H1 | –0.16 | –0.01 | –0.13 | –0.16 | |||||||
| Total sample | –0.12 | 0.02 | –0.16 | –0.23 | |||||||
| MOCA | H1/H1 | 25.0 | 24.6 | 23.4 | 22.6 | 0.05 | 0.83 | 12.46 | 0.001 | 0.21 | 0.89 |
| Non-H1/H1 | 24.9 | 24.7 | 23.9 | 23.0 | |||||||
| Total sample | 25.0 | 24.6 | 23.6 | 22.8 | |||||||
[i] Note: Sample N = 99. Individual analysis degrees of freedom vary slightly due to missing data. Analyses control for age at baseline and years of education. Bolded p values are significant at p ≤ 0.05. MOCA = Montreal Cognitive Assessment.
a H1/H1 haplotype n = 57; Non-H1/H1 haplotype n = 42.
b F-ratio, p for main effect of MAPT haplotype, collapsing across time (evaluation).
c F-ratio, p for main effect of time (evaluation), collapsing across haplotype.
d F-ratio, p for interaction of MAPT haplotype and time.