Figure 1
Alcohol effect on harmaline tremor. Motion power in groups of mice followed sequentially during 15-minute epochs at baseline (B), pre-treatment harmaline (H1, H2), and after vehicle or alcohol injection (arrow, E1–E4). (A) In δ+/+ mice ethanol, 0.50 and 0.575 g/kg, suppressed tremor during E1 compared to vehicle controls but (B) not in δ –/– littermates. (C) Similarly, in α6+/+ mice ethanol, 0.50 and 0.575 g/kg, suppressed tremor during E1 compared to vehicle controls but (D) not in α6 –/– littermates. * P > 0.05, ** P > 0.01, *** P > 0.001, ANOVA.
Figure 2
Ganaxolone effect on harmaline tremor. Motion power during baseline (B), pre-treatment harmaline (H1, H2), and after vehicle or ganaxolone injection (arrow, E1–E4). (A) In δ+/+ mice ganaxolone, 7 and 10 mg/kg, suppressed tremor following injection ompared to vehicle controls but (B) not in δ –/– littermates. (C) Similarly, in α6+/+ mice ganaxolone, 7 and 10 mg/kg, suppressed tremor compared to vehicle controls but (D) not in α6 –/– littermates. * P > 0.05, ** P > 0.01, *** P > 0.001, ANOVA.