Figure 1
Number of days with usable data per patient. Each row represents a patient and each column the number of usable hours from one to twenty. The numbers inside each cell, represent the usable number of days for that patient and number of hours.
Table 1
General characteristics of the patients. Patient characteristics of the functional and organic tremor groups for analyzed patients. SD: standard deviation, IQR: interquartile range.
| FUNCTIONAL TREMOR | ORGANIC TREMOR | |
|---|---|---|
| Number of patients | 15 | 21 |
| Age (years), mean (SD) | 61.5 (12.9) | 65.6 (11.1) |
| Sex (male/female) | 9/6 | 15/6 |
| Disease duration (years), median (IQR) | 3.00 (5.25) | 10.00 (36.00) |
| Tremor presence across usable days (%), min-max | 6.9–47.3 | 3.7–85.8 |
| Tremor frequency variability across usable days (IQR in Hz), min-max | 1.2–3.8 | 0.4–2.8 |
| Tremor intensity across usable days (MAV), min-max | 0.2–21.2 | 0.1–15.3 |
Figure 2
Cumulative median of the three tremor characteristics. Mean subtracted plots for tremor percentage (upper) and tremor frequency variability (middle) and tremor intensity (lower). Each line represents a patient.
Table 2
Results of the three tremor characteristics. Summary of the results obtained for tremor percentage, tremor frequency variability and tremor intensity for the three groups (whole group, FT: functional tremor and OT: organic tremor). Results are reported as median (iqr), for non-normally distributed tremor percentage and tremor intensity data and as mean (SD) for normally distributed tremor frequency variability data.
| TREMOR PERCENTAGE | TREMOR FREQUENCY VARIABILITY | TREMOR INTENSITY | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| WHOLE GROUP | OT | FT | WHOLE GROUP | OT | FT | WHOLE GROUP | OT | FT | |||
| Day1 | 22.8 (19.1) | 24.5 (18.3) | 18.6 (18.8) | 1.6 (0.6) | 1.4 (0.5) | 1.9 (0.6) | 0.9 (2.6) | 0.9 (2.7) | 0.9 (2.6) | ||
| Day2 | 23.7 (18.6) | 32.5 (18.7) | 19.7 (16.7) | 1.7 (0.6) | 1.4 (0.5) | 2.1 (0.5) | 1.2 (2.3) | 1.3 (2.8) | 1.2 (2.1) | ||
| Day3 | 24.0 (15.9) | 24.6 (17.6) | 17.5 (13.7) | 1.7 (0.5) | 1.4 (0.4) | 2.1 (0.3) | 0.9 (2.1) | 0.9 (2.1) | 1.6 (2.8) | ||
| Day4 | 25.1 (19.3) | 29.6 (22.4) | 22.5 (10.8) | 1.6 (0.6) | 1.3 (0.5) | 2.0 (0.5) | 0.7 (1.1) | 0.9 (1.5) | 0.6 (0.9) | ||
| Day5 | 23.9 (22.5) | 25.1 (22.2) | 23.4 (13.9) | 1.7 (0.6) | 1.5 (0.5) | 2.0 (0.6) | 0.6 (2.0) | 0.6 (3.3) | 0.6 (0.7) | ||
| Day6 | 23.9 (21.1) | 28.3 (24.0) | 17.8 (11.7) | 1.8 (0.7) | 1.6 (0.7) | 2.2 (0.7) | 0.7 (1.7) | 1.1 (3.5) | 0.6 (0.6) | ||
| Day7 | 22.8 (16.7) | 27.7 (17.5) | 20.3 (11.1) | 1.7 (0.6) | 1.4 (0.5) | 2.1 (0.5) | 1.2 (2.4) | 1.0 (2.4) | 1.4 (2.3) | ||
| Day8 | 21.6 (15.4) | 28.4 (22.3) | 18.5 (11.4) | 1.7 (0.6) | 1.3 (0.4) | 2.1 (0.6) | 0.8 (2.7) | 0.6 (1.9) | 1.4 (3.0) | ||
| Day9 | 22.3 (19.8) | 24.9 (22.2) | 15.2 (13.8) | 1.7 (0.7) | 1.3 (0.5) | 2.1 (0.6) | 0.7 (2.5) | 0.7 (2.6) | 0.7 (2.1) | ||
| Day10 | 25.4 (18.6) | 27.5 (19.8) | 18.6 (12.9) | 1.7 (0.6) | 1.5 (0.6) | 2.1 (0.5) | 0.7 (1.9) | 0.7 (1.9) | 0.7 (1.9) | ||
| Day11 | 23.9 (17.4) | 25.6 (16.2) | 16.9 (12.4) | 1.7 (0.7) | 1.4 (0.5) | 2.2 (0.6) | 0.7 (1.9) | 0.9 (1.8) | 0.7 (1.8) | ||
| Day12 | 24.3 (17.4) | 26.6 (18.3) | 18.3 (14.2) | 1.7 (0.6) | 1.5 (0.5) | 2.1 (0.7) | 0.7 (1.5) | 0.5 (0.9) | 0.9 (2.6) | ||
Table 3
ICC values for the three tremor characteristics. ICC values for all groups and different time frames from 1 to 10 hrs. Cells with (*) indicate an ICC value higher than 0.75.
| TIME PER DAY (HRS) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | ||
| Tremor percentage | Combined | 0.72 | 0.78* | 0.80* | 0.82* | 0.83* | 0.84* | 0.85* | 0.86* | 0.87* | 0.87* |
| OT | 0.72 | 0.79* | 0.82* | 0.84* | 0.84* | 0.85* | 0.86* | 0.87* | 0.87* | 0.88* | |
| FT | 0.66 | 0.74 | 0.74 | 0.74 | 0.76* | 0.78* | 0.80* | 0.82* | 0.84* | 0.82* | |
| Tremor frequency | Combined | 0.56 | 0.64 | 0.72 | 0.75 | 0.76* | 0.78* | 0.81* | 0.81* | 0.82* | 0.83* |
| OT | 0.42 | 0.45 | 0.51 | 0.59 | 0.60 | 0.63 | 0.66 | 0.66 | 0.67 | 0.71 | |
| FT | 0.53 | 0.63 | 0.75 | 0.74 | 0.77* | 0.78* | 0.82* | 0.82* | 0.83* | 0.83* | |
| Tremor intensity | Combined | 0.52 | 0.60 | 0.64 | 0.69 | 0.71 | 0.71 | 0.70 | 0.72 | 0.74 | 0.77* |
| OT | 0.46 | 0.59 | 0.65 | 0.72 | 0.75 | 0.73 | 0.70 | 0.70 | 0.72 | 0.72 | |
| FT | 0.60 | 0.62 | 0.65 | 0.65 | 0.67 | 0.69 | 0.71 | 0.74 | 0.77* | 0.83* | |
Table 4
Results from the reliability analysis using Spearman-Brown formula. Reliability analysis using the Spearman-Brown formula, each number in the cell represents the new ICC value and the number between brackets is the number of days needed to obtain such reliability value. Here, NA stands for Non-Applicable since the ICC value for a single day is already higher that 0.75 (Table 3).
| TIME PER DAY (HRS) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | ||
| Tremor percentage | Combined | 0.83 (2) | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| OT | 0.83 (2) | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| FT | 0.79 (2) | 0.85 (2) | 0.85 (2) | 0.85 (2) | NA | NA | NA | NA | NA | NA | |
| Tremor frequency | Combined | 0.79 (3) | 0.78 (2) | 0.83 (2) | 0.85 (2) | NA | NA | NA | NA | NA | NA |
| OT | 0.78 (5) | 0.77 (4) | 0.76 (3) | 0.81 (3) | 0.81 (3) | 0.81 (3) | 0.79 (2) | 0.80 (2) | 0.80 (2) | 0.83 (2) | |
| FT | 0.77 (3) | 0.77 (2) | 0.85 (2) | 0.85 (2) | NA | NA | NA | NA | NA | NA | |
| Tremor intensity | Combined | 0.76 (3) | 0.81 (3) | 0.78 (2) | 0.81 (2) | 0.83 (2) | 0.83 (2) | 0.79 (4) | 0.82 (2) | 0.84 (2) | NA |
| OT | 0.77 (4) | 0.81 (3) | 0.79 (2) | 0.83 (2) | 0.84 (2) | 0.84 (2) | 0.80 (3) | 0.82 (2) | 0.83 (2) | 0.83 (2) | |
| FT | 0.76 (2) | 0.81 (3) | 0.77 (2) | 0.78 (2) | 0.80 (2) | 0.81 (2) | 0.78 (5) | 0.83 (2) | 0.86 (2) | NA | |