Video 1
Clinical examination in both fraternal twins. They both present with cerebellar gait and dysmetria as well as distal postural and action tremor of the upper limbs. In addition, the boy displays mild spastic gait and the girl dystonic tremor of the neck (barely noticeable on the video due to regular botulinum toxin injections) as well as dystonic postures of the upper limbs.
Figure 1
Brain MRI of fraternal twins (boy: a-b-c-d-e and girl: f-g-h-i-j). Axial FLAIR-weighted images (a-b-c-d/f-g-h-i) showing diffuse but mild hyperintensities (arrows) of the cortico-spinal tracts with T1-isointensity (e and j), associated with mild hypointensities of the globus pallidi (arrowheads), suggesting a hypomyelinating leukoencephalopathy.