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Orthostatic Tremor is Responsive to Bilateral Thalamic Deep Brain Stimulation: Report of Two Cases Performed Asleep Cover

Orthostatic Tremor is Responsive to Bilateral Thalamic Deep Brain Stimulation: Report of Two Cases Performed Asleep

Open Access
|Jul 2018

Figures & Tables

Video 1.

Case 1. Pre-deep brain stimulation (DBS). The patient had almost immediate onset of orthostatic leg tremors on standing and had extreme difficulty standing without holding on to the table or walls. Post DBS (10 months). The patient demonstrates no visible tremor on standing, and has no difficulty at all standing in place without support.

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Figure 1

Imaging of Lead Placement. (A) Case 1. Preoperative magnetic resonance imaging and post‐lead intraoperative computed tomography (CT) scan are co‐registered using Medtronic FrameLink software. Targeted contacts are contact 1 on the left (L1) and contact 9 on the right (R2). On the left, the stereotactic error of contact 1 is 1.1 mm from the intended target (–14.25, 6.35, 0). On the right, the stereotactic error of contact 9 is 1.1 mm from the intended target (–14.25, 6.35, 0) (active contacts: left, case(+), 1–, 3–; right, 11+, 9–, 10–). (B) Case 2. Intraoperative post‐lead placement CT shows the position of contact 2 on the left ventralis intermedius (VIM) lead (L2), and contact 9 on the right VIM lead (R2). Contact 2 has a radial error of 0.9 mm off of the stereotactic plan targeting (–13.5, –6.75, 0). Contact 9 has a radial error of 0.7 mm off of the stereotactic plan targeting (13.5, –6.75, 0) (active contact: left, case(+), 2–; right, 11+, 8–,10–; contact 9 is shown because it is between contacts 8 and 10.

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Figure 2

Surface Electromyography (EMG) Recordings. (A) Postoperative surface electromyography (EMG) recording of the right tibialis anterior of case 1 while standing with the deep brain stimulator off. Note the prominent high‐frequency tremor of 10–13 Hz. (B) Postoperative surface EMG of the right tibialis anterior of case 1 while standing with deep brain stimulator on. Note the significant attenuation of the tremor activity in terms of frequency, amplitude, and continuity, with prolonged periods of quiescence.

Video 2.

Case 2. Pre‐deep brain stimulation (DBS). Note buckling of the knees and severe difficulty standing in place because of severe orthostatic leg tremors that were apparent immediately upon standing. The patient requires assistance from one person to remain standing in place and intermittently with slow ambulation. Post DBS (1 month). There is improvement of the buckling of the knees on standing with little orthostatic leg tremor noted. The patient can stand better on his own or with a cane.

DOI: https://doi.org/10.5334/tohm.417 | Journal eISSN: 2160-8288
Language: English
Submitted on: Apr 15, 2018
Accepted on: Jul 9, 2018
Published on: Jul 27, 2018
Published by: Columbia University Libraries/Information Services
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2018 Virgilio Gerald H. Evidente, Zachary J. Baker, Maris H. Evidente, Robin Garrett, Margaret Lambert, Francisco A. Ponce, published by Columbia University Libraries/Information Services
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.