Figure 1
Effect of THIP on Harmaline-induced Tremor in Gabrd+/+ and –/– Littermates. (A) Motion power percentage, representing the portion of 8–32 Hz motion power falling within the 10–16 Hz tremor bandwidth is shown during pre-harmaline baseline (B), followed by pre-THIP exposure to harmaline (H), and then following THIP injection (H + T) in Gabrd+/+ mice that received 0, 2, or 3 mg/kg. These wild-type mice displayed robust 10–16 Hz harmaline tremor that was reduced by THIP, 3 mg/kg. (B) In contrast, littermate mice lacking the δ subunit failed to display any tremor suppression by THIP. Mean and standard error of the mean are shown; ***p < 0.001, two-tailed Student t test.
