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Reduced Frequency of Ipsilateral Express Saccades in Cervical Dystonia: Probing the Nigro-Tectal Pathway Cover

Reduced Frequency of Ipsilateral Express Saccades in Cervical Dystonia: Probing the Nigro-Tectal Pathway

Open Access
|Nov 2018

Figures & Tables

Table 1

Summary of Participants with CD

CodeSide of CDAgeGender
CD1Left61F
CD2Left59M
CD3Right49M
CD4Right60F
CD5Right64F
CD6Right61F
CD7Right60F
CD8Left54M

[i] Abbreviations: CD, cervical dystonia; F, Female; M, Male.

[ii] The table provides a summary profile of our participants with CD, noting side of head turn/torticollis, age (years), and gender.

tre-08-592-7522-1-g001.jpg
Figure 1

Electro‐oculography (EOG) Data from a Sample Leftward Trial. (A) The smoothed (0.2–6 Hz) and higher resolution (0.2–125 Hz) EOG is shown for the right (red) and left (blue) signals. Smoothed vertical EOG is also shown (dotted). The onset of the fixation cross occurs at zero (start of trial). The red dotted vertical lines represent target onset and the black vertical line represents blink onset/trial end. The solid vertical green line marks saccade onset. The dashed vertical green line just prior to saccade onset marks the initial estimate of saccade onset. The inset shows magnified horizontal EOG (both smoothed and high definition) from target onset to 0.5 seconds after target onset. Again saccade onset and initial saccade onset are indicated by vertical lines. (B) The differentiated horizontal and vertical smoothed EOG, with vertical lines as above. See explanations in text.

Table 2

Summary of Saccadic Reaction Times and Percentage of Express Saccades.

SRT% Saccades SRT< 140 ms%Saccades SRT < subject 10th %tile
LeftRightLeftRightLeftRight
Pro (ms)Gap (ms)Anti (ms)Pro (ms)Gap (ms)Anti (ms)Gap (%)Gap (%)10th %tile (ms)Gap (%)10th %tile (ms)Gap (%)
CDμ22517731321415931822291745016755
SD624446503145182735133419
HCμ19915628420615129237371524715653
SD332535471832262216212122

[i] Abbreviations: CD, cervical dystonia; HC, healthy controls; μ, Mean; SD, Standard deviation; SRT, Saccadic Reaction Time; 10th %tile, 10th percentile of the pro‐saccade distribution (see text).

[ii] Summary results for participants CD (n  =  8) and HC (n  =  11). Shown are the group μ and SD values for each parameter. % Saccades in the gap task with an SRT below a threshold (140 ms, or a subject‐specific threshold). Values shown for leftward and rightward movements.

tre-08-592-7522-1-g002.jpg
Figure 2

Distributions of Saccadic Reaction Times (SRTs). SRT distributions for leftward and rightward saccades under pro‐saccade (white) and gap (blue) conditions. Each row represents the left and right SRTs for one subject. (A) Cervical dystonia (CD), n  =  8. (b) Health controls (HC), n  =  11. Dotted black vertical lines mark the 10th percentile of the pro‐saccade distribution in each case. This is used as the subject‐specific threshold for the identification of express saccades. Compare this to the more traditional, predefined threshold of 140 ms.

tre-08-592-7522-1-g003.jpg
Figure 3

Percentage of Express Saccades. Percentage of saccades below threshold (express saccades) in the gap task (A) and anti‐saccade task (B). Results are shown for percentage of saccades below each of the “hard” threshold of 140 ms (%ES, express saccades), and the dynamic, subject‐specific threshold (% < 10th, 10th percentile of the saccadic reaction time distribution for the pro‐saccade task for that individual). Data from individuals with cervical dystonia (CD) black asterisks (n  =  8), and healthy controls (HC) ‘o’ (n  =  11).

DOI: https://doi.org/10.5334/tohm.404 | Journal eISSN: 2160-8288
Language: English
Submitted on: Jul 20, 2018
Accepted on: Oct 2, 2018
Published on: Nov 16, 2018
Published by: Columbia University Libraries/Information Services
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2018 Rebecca B. Beck, Simone L. Kneafsey, Shruti Narasimham, Sean O’Riordan, Tadashi Isa, Michael Hutchinson, Richard B. Reilly, published by Columbia University Libraries/Information Services
This work is licensed under the Creative Commons License.