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Eighth International Chorea–Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points Cover

Eighth International Chorea–Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points

Tremor and Other Hyperkinetic Movements
Volume 7 (2017): Issue 0
By: Samuel S. Pappas,  Juan Bonifacino,  Adrian Danek,  William T. Dauer,  Mithu De,  Lucia De Franceschi,  Gilbert DiPaolo,  Robert Fuller,  Volker Haucke,  Andreas Hermann,  Benoit Kornmann,  Bernhard Landwehrmeyer,  Johannes Levin,  Aaron M. Neiman,  Dobrila D. Rudnicki,  Ody Sibon,  Antonio Velayos-Baeza,  Jan J. Vonk,  Ruth H. Walker,  Lois S. Weisman and  Roger L. Albin  
Open Access
|Feb 2017

Figures & Tables

Table 1

VPS13 Nomenclature

GeneProtein
S. cerevisiae
VPS13Vacuolar Protein Sorting-associated protein 13 (Vps13p)
D. melanogaster
Vps13Vacuolar Protein Sorting-associated protein 13 (VPS13)
H. sapiens
VPS13AChorein
Vacuolar Protein Sorting-associated protein 13A (VPS13A)
VPS13BVacuolar Protein Sorting-associated protein 13B (VPS13B)
VPS13CVacuolar Protein Sorting-associated protein 13C (VPS13C)
VPS13DVacuolar Protein Sorting-associated protein 13D (VPS13D)
Table 2

Known Vps13p (yeast) Localizations, Functions, and Interactions

LocalizationsFunctionsInteractions
Late endosome/PVCTGN to PVC transportCdc31p–yeast centrin
TGNTGN homotypic fusion
Nuclear–vacuolar junctionUnknown
Prospore membraneProspore membrane maturation and fusionSpo71p
Vacuolar–mitochondrial junctionMitochondrial integrityMcp1p
Lipid droplet aggregatesUnknown

[i] Abbreviations: PVC, Prevacuolar Compartment; TGN, Trans-Golgi network.

tre-07-428-7522-1-g001.jpg
Figure 1

Three-dimensional Architecture of Purified Yeast Vps13 Protein. The Vps13 structure was determined using negative-stain electron micrograph image analysis. Further biochemical and structural analyses of yeast Vps13p are described in reference 19.

tre-07-428-7522-1-g002.jpg
Figure 2

Yeast Vps13p Localization. Yeast Vps13 localization is dependent on the carbon source. In cells grown in glucose (left ), Vps13–GFP is present in cytoplasmic punctae that predominantly co-localize with endosomal markers. When cells are grown in the non-fermentable carbon source acetate (right ), Vps13–GFP concentrates at the membrane contact site between the nuclear and vacuolar membranes. Dashed lines indicate the outlines of the budding cells. Scale bar  =  5 µm. Further details regarding Vps13 localizations have been previously published.5,18

DOI: https://doi.org/10.5334/tohm.368 | Journal eISSN: 2160-8288
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Language: English
Submitted on: Oct 4, 2016
Accepted on: Jan 10, 2017
Published on: Feb 15, 2017
Published by: Columbia University Libraries/Information Services
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
Chorea Acanthocytosis,
Neuroacanthocytosis,
VPS13,
VPS13A,
Chorein

© 2017 Samuel S. Pappas, Juan Bonifacino, Adrian Danek, William T. Dauer, Mithu De, Lucia De Franceschi, Gilbert DiPaolo, Robert Fuller, Volker Haucke, Andreas Hermann, Benoit Kornmann, Bernhard Landwehrmeyer, Johannes Levin, Aaron M. Neiman, Dobrila D. Rudnicki, Ody Sibon, Antonio Velayos-Baeza, Jan J. Vonk, Ruth H. Walker, Lois S. Weisman, Roger L. Albin, published by Columbia University Libraries/Information Services
This work is licensed under the Creative Commons License.

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