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Essential Tremor: What We Can Learn from Current Pharmacotherapy Cover

Essential Tremor: What We Can Learn from Current Pharmacotherapy

By: William Ondo  
Open Access
|Mar 2016

References

  1. 1
    BuijinkAWvan der StouweAMBroersmaMet alMotor network disruption in essential tremor: A functional and effective connectivity studyBrain201513829342947doi: http://dx.doi.org/10.1093/brain/awv22526248468
  2. 2
    Erickson-DavisCRFaustPLVonsattelJPGuptaSHonigLSLouisED“Hairy baskets” associated with degenerative Purkinje cell changes in essential tremorJ Neuropathol Exp Neurol201069262271doi: http://dx.doi.org/10.1097/NEN.0b013e3181d1ad0420142764
  3. 3
    RajputAHAdlerCHShillHARajputAEssential tremor is not a neurodegenerative diseaseNeurodegener Dis Manag20122259268doi: http://dx.doi.org/10.2217/nmt.12.2323105950
  4. 4
    ShillHAAdlerCHSabbaghMNet alPathologic findings in prospectively ascertained essential tremor subjectsNeurology20087014521455doi: http://dx.doi.org/10.1212/01.wnl.0000310425.76205.0218413570
  5. 5
    SymanskiCShillHADuggerBet alEssential tremor is not associated with cerebellar Purkinje cell lossMov Disord201429496500doi: http://dx.doi.org/10.1002/mds.2584524532134
  6. 6
    MallyJBaranyiMViziESChange in the concentrations of amino acids in CSF and serum of patients with essential tremorJ Neural Transm19961035555608811501
  7. 7
    ShillHAAdlerCHBeachTGet alBrain biochemistry in autopsied patients with essential tremorMov Disord201227113117doi: http://dx.doi.org/10.1002/mds.2400422038525
  8. 8
    FruchtSJHoughtonWCBordelonYGreenePELouisEDA single-blind, open-label trial of sodium oxybate for myoclonus and essential tremorNeurology2005651967196916382538
  9. 9
    NahabFBWittevrongelLIppolitoDet alAn open-label, single-dose, crossover study of the pharmacokinetics and metabolism of two oral formulations of 1-octanol in patients with essential tremorNeurotherapeutics20118753762doi: http://dx.doi.org/10.1007/s13311-011-0045-121594724
  10. 10
    TeravainenHHuttunenJLewittPIneffective treatment of essential tremor with an alcohol, methylpentynolJ Neurol Neurosurg Psychiatry1986491981993512778
  11. 11
    HopfnerFErhartTKnudsenKet alTesting for alcohol sensitivity of tremor amplitude in a large cohort with essential tremorParkinsonism Relat Disord201521848851doi: http://dx.doi.org/10.1016/j.parkreldis.2015.05.00526002382
  12. 12
    MostileGJankovicJAlcohol in essential tremor and other movement disordersMov Disord20102522742284doi: http://dx.doi.org/10.1002/mds.2324020721919
  13. 13
    KollerWCBiaryNEffect of alcohol on tremors: Comparison with propranololNeurology198434221222doi: http://dx.doi.org/10.1212/WNL.34.2.2216538013
  14. 14
    ZeunerKEMolloyFMShogeROGoldsteinSRWesleyRHallettMEffect of ethanol on the central oscillator in essential tremorMov Disord20031812801285doi: http://dx.doi.org/10.1002/mds.1055314639668
  15. 15
    BoeckerHWillsAJCeballos-BaumannAet alThe effect of ethanol on alcohol-responsive essential tremor: A positron emission tomography studyAnn Neurol199639650658doi: http://dx.doi.org/10.1002/ana.4103905158619551
  16. 16
    GrowdonJHShahaniBTYoungRRThe effect of alcohol on essential tremorNeurology197525259doi: http://dx.doi.org/10.1212/WNL.25.3.2591167633
  17. 17
    LeznikELlinasRRole of gap junctions in synchronized neuronal oscillations in the inferior oliveJ Neurophysiol2005942447245615928056
  18. 18
    AdermarkLOlssonTHanssonEEthanol acutely decreases astroglial gap junction permeability in primary cultures from defined brain regionsNeurochem Int200445971978doi: http://dx.doi.org/10.1016/j.neuint.2004.06.00715337295
  19. 19
    MustonenHKiviluotoTPaimelaHPuolakkainenPKivilaaksoECalcium signaling is involved in ethanol induced volume decrease and gap junction closure in cultured rat gastric mucosal cellsDig Dis Sci200550103110doi: http://dx.doi.org/10.1007/s10620-005-1286-915712646
  20. 20
    WentlandtKKushnirMNausCCCarlenPLEthanol inhibits gap-junctional coupling between P19 cellsAlcohol Clin Exp Res20042812841290doi: http://dx.doi.org/10.1097/01.ALC.0000139705.17646.BA15365297
  21. 21
    SinclairJGLoGFHarrisDPEthanol effects on the olivocerebellar systemCan J Physiol Pharmacol198260610614doi: http://dx.doi.org/10.1139/y82-0827104848
  22. 22
    MameliMBottaPZamudioPAZuccaSValenzuelaCFEthanol decreases Purkinje neuron excitability by increasing GABA release in rat cerebellar slicesJ Pharmacol Exp Ther2008327910917doi: http://dx.doi.org/10.1124/jpet.108.14486518755936
  23. 23
    KumarSPorcuPWernerDFet alThe role of GABA(A) receptors in the acute and chronic effects of ethanol: A decade of progressPsychopharmacology2009205529564doi: http://dx.doi.org/10.1007/s00213-009-1562-z19455309
  24. 24
    OlsenRWSieghartWGABA A receptors: Subtypes provide diversity of function and pharmacologyNeuropharmacology200956141148doi: http://dx.doi.org/10.1016/j.neuropharm.2008.07.04518760291
  25. 25
    ZheleznovaNNSedelnikovaAWeissDSFunction and modulation of delta-containing GABA(A) receptorsPsychoneuroendocrinology200934Suppl. 1S67S73doi: http://dx.doi.org/10.1016/j.psyneuen.2009.08.01019766404
  26. 26
    SankarRGABA(A) receptor physiology and its relationship to the mechanism of action of the 1,5-benzodiazepine clobazamCNS Drugs201226229244doi: http://dx.doi.org/10.2165/11599020-000000000-0000022145708
  27. 27
    GironellAThe GABA hypothesis in essential tremor: lights and shadowsTremor Other Hyperkinet Mov (NY20144doi: http://dx.doi.org/10.7916/D8SF2T9C
  28. 28
    WakitaMShinMCIwataSNonakaKAkaikeNEffects of ethanol on GABA(A) receptors in GABAergic and glutamatergic presynaptic nerve terminalsJ Pharmacol Exp Ther2012341809819doi: http://dx.doi.org/10.1124/jpet.111.18912622434676
  29. 29
    KelmMKCriswellHEBreeseGREthanol-enhanced GABA release: A focus on G protein-coupled receptorsBrain Res Rev201165113123doi: http://dx.doi.org/10.1016/j.brainresrev.2010.09.00320837058
  30. 30
    CushmanJDMooreMDJacobsNSOlsenRWFanselowMSBehavioral pharmacogenetic analysis on the role of the alpha4 GABA(A) receptor subunit in the ethanol-mediated impairment of hippocampus-dependent contextual learningAlcohol Clin Exp Res20113519481959doi: http://dx.doi.org/10.1111/j.1530-0277.2011.01546.x21943327
  31. 31
    GlykysJPengZChandraDHomanicsGEHouserCRModyIA new naturally occurring GABA(A) receptor subunit partnership with high sensitivity to ethanolNat Neurosci2007104048doi: http://dx.doi.org/10.1038/nn181317159992
  32. 32
    MihalekRMBowersBJWehnerJMet alGABA(A)-receptor delta subunit knockout mice have multiple defects in behavioral responses to ethanolAlcohol Clin Exp Res2001251708171811781502
  33. 33
    WeiWFariaLCModyILow ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABAA receptors in hippocampal neuronsJ Neurosci20042483798382doi: http://dx.doi.org/10.1523/JNEUROSCI.2040-04.200415385620
  34. 34
    MantoMLauteMAA possible mechanism for the beneficial effect of ethanol in essential tremorEur J Neurol200815697705doi: http://dx.doi.org/10.1111/j.1468-1331.2008.02150.x18445025
  35. 35
    ShahidullahMHarrisTGermannMWCovarrubiasMMolecular features of an alcohol binding site in a neuronal potassium channelBiochemistry2003421124311252doi: http://dx.doi.org/10.1021/bi034738f14503874
  36. 36
    de HaasSLZoethoutRWVan DyckKet alThe effects of TPA023, a GABAAalpha2,3 subtype-selective partial agonist, on essential tremor in comparison to alcoholJ Psychopharmacol201226282291doi: http://dx.doi.org/10.1177/026988111141573121890585
  37. 37
    GreenfieldLJJrMolecular mechanisms of antiseizure drug activity at GABAA receptorsSeizure201322589600doi: http://dx.doi.org/10.1016/j.seizure.2013.04.01523683707
  38. 38
    SassoEPeruccaECalzettiSDouble-blind comparison of primidone and phenobarbital in essential tremorNeurology198838808808doi: http://dx.doi.org/10.1212/WNL.38.5.8083283599
  39. 39
    KollerWCRoyseVLEfficacy of primidone in essential tremorNeurology198636121124doi: http://dx.doi.org/10.1212/WNL.36.1.1213941767
  40. 40
    CalzettiSFindleyLJPisaniFRichensAPhenylethylmalonamide in essential tremor. A double-blind controlled studyJ Neurol Neurosurg Psychiatry1981449329347031184
  41. 41
    GironellAMartinez-CorralMPagonabarragaXKulisevskyJTiagabine for essential tremor: An open-label trialMov Disord20082319551956doi: http://dx.doi.org/10.1002/mds.2209418759354
  42. 42
    ZesiewiczTASullivanKLWardCLHauserRATiagabine and exacerbation of essential tremorMov Disord20072221322133doi: http://dx.doi.org/10.1002/mds.2155917663461
  43. 43
    WalkerSDKalviainenRNon-vision adverse events with vigabatrin therapyActa Neurol Scand20111247282doi: http://dx.doi.org/10.1111/j.1600-0404.2011.01602.x
  44. 44
    MondrupKDupontEPedersenEThe effect of the GABA-agonist, progabide, on benign essential tremor. A controlled clinical trialActa Neurol Scand198368248252doi: http://dx.doi.org/10.1111/j.1600-0404.1983.tb04833.x6362317
  45. 45
    KollerWCRubinoFGuptaSPharmacologic probe with progabide of GABA mechanisms in essential tremorArch Neurol1987449059563619708
  46. 46
    PahapillPALevyRDostrovskyJOet alTremor arrest with thalamic microinjections of muscimol in patients with essential tremorAnn Neurol199946249252doi: http://dx.doi.org/10.1002/1531-8249(199908)46:2<249::AID-ANA15>3.0.CO;2-C10443891
  47. 47
    FruchtSJBordelonYHoughtonWHReardanDA pilot tolerability and efficacy trial of sodium oxybate in ethanol-responsive movement disordersMov Disord20052013301337doi: http://dx.doi.org/10.1002/mds.2060515986420
  48. 48
    LiQKuhnCMWilsonWALewisDVEffects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortexNeuroscience20071508292doi: http://dx.doi.org/10.1016/j.neuroscience.2007.08.02317904295
  49. 49
    WeissNNorthRBOharaSLenzFAAttenuation of cerebellar tremor with implantation of an intrathecal baclofen pump: The role of gamma-aminobutyric acidergic pathways. Case reportJ Neurosurg200399768771doi: http://dx.doi.org/10.3171/jns.2003.99.4.076814567614
  50. 50
    BusenbarkKPahwaRHubbleJKollerWThe effect of acetazolamide on essential tremor: An open-label trialNeurology19924213941394doi: http://dx.doi.org/10.1212/WNL.42.7.13941620352
  51. 51
    GunalDIAfsarNBekirogluNAktanSNew alternative agents in essential tremor therapy: Double-blind placebo-controlled study of alprazolam and acetazolamideNeurol Sci200021315317doi: http://dx.doi.org/10.1007/s10072007006911286044
  52. 52
    BusenbarkKPahwaRHubbleJHopfenspergerKKollerWPogrebraKDouble-blind controlled study of methazolamide in the treatment of essential tremorNeurology19934310451047doi: http://dx.doi.org/10.1212/WNL.43.5.10458492925
  53. 53
    BusenbarkKRamigLDromeyCKollerWCMethazolamide for essential voice tremorNeurology19964713311332doi: http://dx.doi.org/10.1212/WNL.47.5.13318909454
  54. 54
    OndoWHunterCVuongKDSchwartzKJankovicJGabapentin for essential tremor: A multiple-dose, double-blind, placebo-controlled trialMov Disord200015678682doi: http://dx.doi.org/10.1002/1531-8257(200007)15:4<678::AID-MDS1012>3.0.CO;2-010928578
  55. 55
    PahwaRLyonsKHubbleJPet alDouble-blind controlled trial of gabapentin in essential tremorMov Disord199813465467doi: http://dx.doi.org/10.1002/mds.8701303159613738
  56. 56
    ZesiewiczTASullivanKLHinsonVet alMultisite, double-blind, randomized, controlled study of pregabalin for essential tremorMov Disord201328249250doi: http://dx.doi.org/10.1002/mds.2526423238907
  57. 57
    FerraraJMKenneyCDavidsonALShinawiLKisselAMJankovicJEfficacy and tolerability of pregabalin in essential tremor: A randomized, double-blind, placebo-controlled, crossover trialJ Neurol Sci2009285195197doi: http://dx.doi.org/10.1016/j.jns.2009.06.04419631949
  58. 58
    GironellAKulisevskyJBarbanojMLopez-VillegasDHernandezGPascual-SedanoBA randomized placebo-controlled comparative trial of gabapentin and propranolol in essential tremorArch Neurol199956475480doi: http://dx.doi.org/10.1001/archneur.56.4.47510199338
  59. 59
    BusharaKOMalikTExcondeREThe effect of levetiracetam on essential tremorNeurology20056410781080doi: http://dx.doi.org/10.1212/01.WNL.0000154596.21335.2E15781835
  60. 60
    OndoWGJimenezJEVuongKDJankovicJAn open-label pilot study of levetiracetam for essential tremorClin Neuropharmacol200427274277doi: http://dx.doi.org/10.1097/00002826-200411000-0000415613931
  61. 61
    Mendoza-TorreblancaJGVanoye-CarloAPhillips-FarfanBVCarmona-AparicioLGomez-LiraGSynaptic vesicle protein 2A: Basic facts and role in synaptic functionEur J Neurosci20133835293539doi: http://dx.doi.org/10.1111/ejn.1236024102679
  62. 62
    HandforthABordelonYFruchtSJQuesadaAA pilot efficacy and tolerability trial of memantine for essential tremorClin Neuropharmacol201033223226doi: http://dx.doi.org/10.1097/WNF.0b013e3181ebd10920838216
  63. 63
    GironellAKulisevskyJPascual-SedanoBFlamarichDEffect of amantadine in essential tremor: A randomized, placebo-controlled trialMov Disord20062144144516229019
  64. 64
    HandforthAHomanicsGECoveyDFet alT-type calcium channel antagonists suppress tremor in two mouse models of essential tremorNeuropharmacology201059380387doi: http://dx.doi.org/10.1016/j.neuropharm.2010.05.01220547167
  65. 65
    MiwaHKohJKajimotoYKondoTEffects of T-type calcium channel blockers on a parkinsonian tremor model in ratsPharmacol Biochem Behav201197656659doi: http://dx.doi.org/10.1016/j.pbb.2010.11.01421112351
  66. 66
    MitsudaMNomotoMIwataSEffects of beta-blockers and nicardipine on oxotremorine-induced tremor in common marmosetsJpn J Pharmacol199981244246doi: http://dx.doi.org/10.1254/jjp.81.24410591485
  67. 67
    LeighPNJeffersonDTwomeyAMarsdenCDBeta-adrenoreceptor mechanisms in essential tremor; A double-blind placebo controlled trial of metoprolol, sotalol and atenololJ Neurol Neurosurg Psychiatry1983467107156310053
  68. 68
    ZoethoutRWIannoneRBloemBRet alThe effects of a novel histamine-3 receptor inverse agonist on essential tremor in comparison to stable levels of alcoholJ Psychopharmacol201226292302doi: http://dx.doi.org/10.1177/026988111139868521335358
  69. 69
    LeeKSKimJSKimJWLeeWYJeonBSKimDA multicenter randomized crossover multiple-dose comparison study of arotinolol and propranolol in essential tremorParkinsonism Relat Disord20039341347doi: http://dx.doi.org/10.1016/S1353-8020(03)00029-412853233
  70. 70
    SongIUHaSWYangYSChungYADifferences in regional glucose metabolism of the brain measured with F-18-FDG-PET in patients with essential tremor according to their response to beta-blockersKorean J Radiol201516967972doi: http://dx.doi.org/10.3348/kjr.2015.16.5.96726357492
  71. 71
    KollerWCBiaryNMetoprolol compared with propranolol in the treatment of essential tremorArch Neurol198441171172doi: http://dx.doi.org/10.1001/archneur.1984.040501400690266691818
  72. 72
    CalzettiSFindleyLJGrestyMAPeruccaERichensAMetoprolol and propranolol in essential tremor: A double-blind, controlled studyJ Neurol Neurosurg Psychiatry1981448148197031187
  73. 73
    JeffersonDWharradHJBirminghamATPatrickJMThe comparative effects of ICI 118551 and propranolol on essential tremorBr J Clin Pharmacol1987247297342894217
  74. 74
    KollerWOrebaughCLawsonLPotempaKPindolol-induced tremorClin Neuropharmacol198710449452doi: http://dx.doi.org/10.1097/00002826-198710000-000073332615
  75. 75
    KralicJECriswellHEOstermanJLet alGenetic essential tremor in gamma-aminobutyric acid A receptor alpha1 subunit knockout miceJ Clin Invest200511577477915765150
  76. 76
    MartinFCThu LeAHandforthAHarmaline-induced tremor as a potential preclinical screening method for essential tremor medicationsMov Disord200520298305doi: http://dx.doi.org/10.1002/mds.2033115580562
  77. 77
    PatersonNEMalekianiSAForemanMMOlivierBHananiaTPharmacological characterization of harmaline-induced tremor activity in miceEur J Pharmacol20096167380doi: http://dx.doi.org/10.1016/j.ejphar.2009.05.03119497322
  78. 78
    HandforthAHarmaline tremor: Underlying mechanisms in a potential animal model of essential tremorTremor Other Hyperkinet Mov (N Y)20122doi: http://dx.doi.org/10.7916/D8TD9W2P
  79. 79
    MartinFCHandforthACarbenoxolone and mefloquine suppress tremor in the harmaline mouse model of essential tremorMov Disord20062116411649doi: http://dx.doi.org/10.1002/mds.2094016773639
DOI: https://doi.org/10.5334/tohm.318 | Journal eISSN: 2160-8288
Language: English
Submitted on: Oct 12, 2015
Accepted on: Dec 17, 2015
Published on: Mar 4, 2016
Published by: Columbia University Libraries/Information Services
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2016 William Ondo, published by Columbia University Libraries/Information Services
This work is licensed under the Creative Commons License.