Dear Editor,
This is in reply to a letter written by Dokyung Lee and Tae-Beom Ahn with reference to two articles related to glycemic choreoballism (gCB) published in your journal.1,2
It is accurate that the clinical outcome of gCB is variable, although the majority of the literature states that it is a treatable disorder with a good prognosis.3–5
However, the diagnostic criteria for gCB would be incomplete unless we exclude other causes of hemichorea hemiballism (HCHB).
Management of gCB is mainly based on controlling blood sugar levels, but dopamine receptor blocking agents are often essential. Here, we again want to highlight that hyperglycemia can result in an ischemic penumbra and reversible clinical syndrome/neuroimaging abnormalities in patients with HCHB; however, prolonged hyperglycemia may result in true infarction with an irreversible clinical syndrome.6 In summary, a better understanding of gCB requires further research into the pathogenic mechanisms of this disease, which may also aid in its proper management.
Notes
[1] Funding: None.
[2] Financial disclosure Financial Disclosures: None.
[3] Conflict of Interest: The authors report no conflict of interest.
[4] Ethics Statement: Not applicable for this category of article.