Table 1
Comparison of Clinical Characteristics, Tremor Severity, and Programming Parameters by Target
| VIM (n=8) | STN (n=10) | |
|---|---|---|
| M:F | 7:1 | 8:2 |
| Age at onset (mean, SD), years | 54.7 ± 11.9 | 53.6 ± 13.3 |
| Disease duration (mean, SD), years | 10.5 ± 7.5 | 9.8 ± 9.1 |
| Total off medication motor UPDRS score (mean, SD) | 30.6 ± 12.3 | 28.2 ± 14.6 |
| Baseline postural/action score | ||
| Severe, 4 | 5 | 1 |
| Moderately severe, 3 | 0 | 2 |
| Moderate, 2 | 3 | 3 |
| Mild, 1 | 0 | 4 |
| Pre-surgery item 21 score (mean, SD) | 3.3 ± 1.0 | 1.9 ± 1.0 |
| Post-programming item 21 score (mean, SD) | 0.8 ± 0.9 | 0.4 ± 0.5 |
| Rationale for target selection | ||
| Chief complaint action tremor | 8 | |
| Chief complaint resting tremor | 1 | |
| Bothersome levodopa-responsive bradykinesia/rigidity | 4 | |
| Prior thalamotomy | 1 | |
| Younger age (age <60) | 2 | |
| Motor complications | 2 | |
| Percentage improvement (mean, SD) | 71.9 ± 36.4 | 68.1 ± 44.1 |
| Complete postural/action tremor suppression, number of patients (%) | 4 (50%) | 6 (60%) |
| Long-term post-surgery item 21 score (mean, SD) | 1.0 ± 0.8 | 0.3 ± 0.5 |
| Pre-surgery item 20 score (mean, SD) | 3.1 ± 1.4 | 2.9 ± 0.8 |
| Post-programming item 20 score (mean, SD) | 0.4 +/_0.7 | 0.3 ± 0.5 |
| Percentage improvement (mean, SD) | 90.6 ± 18.6 | 88.9 ± 20.5 |
| Complete rest tremor suppression, number of patients (%) | 6 (75%) | 7 (70%) |
| Long-term post-surgery item 20 score (mean, SD) | 0.4 ± 0.7 | 0.2 ± 0.4 |
| Length of follow-up (months, mean, SD) | 48.0 ± 41.0 | 34.9 ± 24.0 |
| Monopolar vs. bipolar stimulation, Number of leads (n=20) | 6:2 | 9:3 |
| Voltage (mean, SD) | 3.3 V ± 0.9 | 3.1 V ± 0.7 |
| Pulse width (mean, SD) | 98 μs ± 41.7 | 75 μs ± 23.9 |
| Frequency (mean, SE) | 164 Hz ± 27.2 | 163 Hz ± 28.9 |
[i] F, Female; M, Male; SD, Standard Deviation; SE, Standard Error; STN, Subthalamic Nucleus; UPDRS, Unified Parkinson’s Disease Rating Scale; VIM, Ventral Intermediate Nucleus.