Figure 1
Schematic Representation of the Gamma-aminobutyric Acid Hypothesis in Essential Tremor.
Table 1
Studies Published Concerning the GABA Hypothesis in ET
| CSF | Purkinje Cell Loss | Pathology GABA | Electrophysiology | Genetic | Animal Models | Imaging | Drug Therapies | |
|---|---|---|---|---|---|---|---|---|
| Pros | Mally et al.21 | Louis et al.15 | Mouginot and Gahwiler20 | Uusiaari and Knopfel24 | Kralic et al.34 | Boecket et al.35 | Theophylline, 199139 | |
| Axelrad et al.16 | Paris-Robidas et al.22 | Pinault and Deschenes28 | Gironell et al.36 | Muscimol, 199140 | ||||
| Louis et al.18 | Shill et al.23 | Gabapentin, 199941 | ||||||
| Gabapentin, 200043 | ||||||||
| Topiramate, 200245 | ||||||||
| Topiramate, 200646 | ||||||||
| Topiramate, 200848 | ||||||||
| Pregabaline, 200750 | ||||||||
| Cons | Rajput et al.61 | Deng et al.29 | Progabide, 198337 | |||||
| Thier et al.30 | Progabide, 198738 | |||||||
| Shill et al.62 | García-Martín et al.31 | Gabapentin, 199942 | ||||||
| Symanski et al.63 | García-Martín et al.32 | Topiramate, 200647 | ||||||
| Tiagabine, 200849 | ||||||||
| Pregabaline, 200951 | ||||||||
| Pregabaline, 201252 |