Temporal Course of the Tourette Syndrome Clinical Triad

David R. Shprecher; Lindsay A. Rubenstein; Keenan Gannon; Samuel A. Frank; Roger Kurlan

doi:10.5334/tohm.195

Figures & Tables

Table 1

Summary of Results: The Temporal Course of TS

	Prevalence in Sample Population	Mean Age at Onset	Mean Age at Peak Symptom Severity	Mean Age at Symptom Lessening	Mean Age at Remission	% Symptom Lessening in Affected Subjects	% Remission in Affected Subjects
TS	100%	7.9 (±3.6)	12.3 (±4.6)	14.7 (±3.7)	17.4 (± 3.8)	83%	32%
ADHD	68%	7.9 (±3.5)	10.8 (±3.8)	13.9 (±2.9)	17.4 (±1.3)	60%	22%
OCD	72%	9.2 (±5.0)	12.6 (±5.5)	15.1 (±5.0	15.6 (±2.3)	68%	21%

[i] ADHD, Attention Deficit Hyperactivity Disorder; OCD, Obsessive Compulsive Disorder; TS, Tourette syndrome.

Table 2

Correlations between temporal course milestones

		Tics Began	Age When Tics Were Worst	Age When Tics Lessened	OC Symptoms Began	ADHD Symptoms Began	ADHD Symptoms Worst	OC Symptoms Worst	OC Symptoms Lessened	ADHD Symptoms Lessened
Tics began	Pearson correlation	1	0.625^**	0.444^**	0.450^**	0.270	0.260	0.455^**	0.255	0.228
	Sig. (2-tailed)		0.000	0.003	0.005	0.117	0.157	0.009	0.209	0.320
Age when tics were worst Correlation	Pearson correlation	0.625^**	1	0.776^**	0.282	0.013	0.361^*	0.635^**	0.233	0.073
	Sig. (2-tailed)	0.000		0.000	0.086	0.940	0.046	0.000	0.252	0.753
Age when tics lessened	Pearson correlation	0.444^**	0.776^**	1	0.326	0.169	0.556^**	0.520^**	0.541^**	0.653^**
	Sig. (2-tailed)	0.003	0.000		0.073	0.363	0.003	0.005	0.006	0.002
OC symptoms began	Pearson correlation	0.450^**	0.282	0.326	1	0.607^**	0.479^*	0.719^**	0.672^**	0.375
	Sig. (2-tailed)	0.005	0.086	0.073		0.001	0.013	0.000	0.000	0.125
ADHD symptoms began	Pearson correlation	0.270	0.013	0.169	0.607^**	1	0.612^**	0.276	0.468^*	0.611^**
	Sig. (2-tailed)	0.117	0.940	0.363	0.001		0.000	0.203	0.043	0.004
ADHD symptoms worst	Pearson correlation	0.260	0.361^*	0.556^**	0.479^*	0.612^**	1	0.611^**	0.679^**	0.826^**
	Sig. (2-tailed)	0.157	0.046	0.003	0.013	0.000		0.002	0.002	0.000
OC symptoms worst	Pearson correlation	^0.455^**	^0.635^**	^0.520^**	^0.719^**	0.276	^0.611^**	1	0.927^**	0.472
	Sig. (2-tailed)	0.009	0.000	0.005	0.000	0.203	0.002		0.000	0.076
OC symptoms lessened	Pearson correlation	0.255	0.233	^0.541^**	^0.672^**	^0.468^*	^0.679^**	^0.927^**	1	0.710^**
	Sig. (2-tailed)	0.209	0.252	0.006	0.000	0.043	0.002	0.000		0.004
ADHD symptoms lessened	Pearson correlation	0.228	0.073	0.653^**	0.375	0.611^**	0.826^**	0.472	0.710^**	1
	Sig. (2-tailed)	0.320	0.753	0.002	0.125	0.004	0.000	0.076	0.004

ADHD, Attention Deficit Hyperactivity Disorder; OC, Obsessive Compulsive.

* Correlation is significant at the 0.05 level (2-tailed).

** Correlation is significant at the 0.01 level (2-tailed).