Prevalence of Diagnosed Essential Tremor Using Electronic Healthcare Records: A Population-Based Study in Northeast-Central Pennsylvania

AGE-SPECIFIC	POPULATION	NEUROLOGY			ALL-SPECIALTIES
AGE-SPECIFIC	POPULATION	CASES	PREVALENCE	95% CI	CASES	PREVALENCE	95% CI
10–19	145,721	40	0.027	0.020–0.037	71	0.049	0.038–0.061
20–29	172,472	156	0.090	0.077–0.106	366	0.212	0.191–0.235
30–39	142,935	190	0.133	0.115–0.153	566	0.396	0.364–0.430
40–49	135,245	229	0.169	0.148–0.193	684	0.506	0.469–0.545
50–59	161,620	466	0.288	0.263–0.316	1114	0.689	0.649–0.731
60–69	158,684	630	0.397	0.367–0.429	1482	0.934	0.887–0.983
70–79	104,320	633	0.607	0.561–0.656	1489	1.427	1.356–1.501
AGE-THRESHOLD		–	–	–	–	–	–
10+	1,081,934	2827	0.261	0.252–0.271	7065	0.653	0.638–0.668
20+	936,213	2787	0.298	0.287–0.309	6994	0.747	0.730–0.765
30+	763,741	2631	0.344	0.332–0.358	6628	0.868	0.847–0.889
40+	620,806	2441	0.393	0.378–0.409	6062	0.976	0.952–1.001
50+	485,561	2212	0.456	0.437–0.475	5378	1.108	1.079–1.137
60+	323,941	1746	0.539	0.514–0.565	4264	1.316	1.278–1.356
70+	165,257	1116	0.675	0.637–0.716	2782	1.683	1.623–1.747
80+	60,937	483	0.793	0.725–0.866	1293	2.122	2.010–2.239

**Age-Specific and Standardized Prevalence of Essential Tremor by Ascertainment Strategy. (A)** Age-specific crude prevalence of essential tremor by ascertainment method. Points represent observed prevalence with 95% confidence intervals; curves represent quadratic polynomial fits. **(B)** Crude and age-standardized prevalence estimates by ascertainment strategy. Error bars represent 95% confidence intervals; standardized estimates were derived using direct age standardization. **(C)** Distribution of age at diagnosis in the mutually exclusive neurology and non-neurology cohorts, shown as histograms with density overlays. **(D)** Age at diagnosis in the neurology and non-neurology cohorts, presented as boxplots; no significant difference was observed between groups (p = 0.77).

Table 2

Age-specific and Age-threshold Prevalence of Essential Tremor by Ascertainment Strategy in Males.

AGE-SPECIFIC	MALES	NEUROLOGY			ALL-SPECIALTIES
AGE-SPECIFIC	MALES	CASES	PREVALENCE	95% CI	CASES	PREVALENCE	95% CI
10–19	73,685	25	0.034	0.022–0.050	37	0.050	0.035–0.069
20–29	90,077	82	0.091	0.072–0.113	182	0.202	0.174–0.234
30–39	73,451	100	0.136	0.111–0.166	285	0.388	0.344–0.436
40–49	68,665	102	0.149	0.121–0.180	317	0.462	0.412–0.515
50–59	81,057	212	0.262	0.228–0.299	493	0.608	0.556–0.664
60–69	77,971	297	0.381	0.339–0.427	672	0.862	0.798–0.929
70–79	48,238	294	0.609	0.542–0.683	685	1.420	1.316–1.530
AGE-THRESHOLD		–	–	–	–	–	–
10+	535,931	1305	0.244	0.231–0.257	3138	0.586	0.565–0.606
20+	462,246	1280	0.277	0.262–0.292	3101	0.671	0.648–0.695
30+	372,169	1198	0.322	0.304–0.341	2919	0.784	0.756–0.813
40+	298,718	1098	0.368	0.346–0.390	2634	0.882	0.849–0.916
50+	230,053	996	0.433	0.407–0.461	2317	1.007	0.967–1.049
60+	148,996	784	0.526	0.491–0.564	1824	1.224	1.170–1.281
70+	71,025	487	0.686	0.628–0.749	1152	1.622	1.532–1.718
80+	22,787	193	0.847	0.736–0.975	467	2.049	1.873–2.242

Table 3

Age-specific and Age-threshold Prevalence of Essential Tremor by Ascertainment Strategy in Females.

AGE-SPECIFIC	FEMALES	NEUROLOGY			ALL-SPECIALTIES
AGE-SPECIFIC	FEMALES	CASES	PREVALENCE	95% CI	CASES	PREVALENCE	95% CI
10–19	72,036	15	0.021	0.012–0.034	34	0.047	0.033–0.066
20–29	82,395	74	0.090	0.071–0.113	184	0.223	0.192–0.258
30–39	69,484	90	0.130	0.104–0.159	281	0.404	0.359–0.454
40–49	66,580	127	0.191	0.159–0.227	367	0.551	0.496–0.610
50–59	80,563	254	0.315	0.278–0.356	621	0.771	0.712–0.834
60–69	80,713	333	0.413	0.370–0.459	810	1.004	0.936–1.075
70–79	56,082	339	0.604	0.542–0.672	804	1.434	1.337–1.535
AGE-THRESHOLD		–	–	–	–	–	–
10+	546,003	1522	0.279	0.265–0.293	3927	0.719	0.697–0.742
20+	473,967	1507	0.318	0.302–0.334	3893	0.821	0.796–0.847
30+	391,572	1433	0.366	0.348–0.385	3709	0.947	0.917–0.978
40+	322,088	1343	0.417	0.395–0.440	3428	1.064	1.029–1.100
50+	255,508	1216	0.476	0.450–0.503	3061	1.198	1.157–1.241
60+	174,945	962	0.550	0.516–0.586	2440	1.395	1.341–1.451
70+	94,232	629	0.668	0.617–0.722	1630	1.730	1.648–1.815
80+	38,150	290	0.760	0.678–0.852	826	2.165	2.024–2.316

**Sex Differences in Essential Tremor Prevalence Across Age Groups and Ascertainment Strategies. (A)** Age-specific prevalence of essential tremor by sex, stratified by ascertainment method. **(B)** Prevalence of essential tremor by sex across increasing age-threshold groups. **(C)** Difference in age-specific prevalence between females and males (female – male) across age groups. **(D)** 95% confidence intervals for the differences in prevalence estimates between females and males across age threshold groups.

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DOI: https://doi.org/10.5334/tohm.1229 | Journal eISSN: 2160-8288

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Language: English

Page range: 45 - 45

Submitted on: May 19, 2026

Accepted on: Jul 2, 2026

Published on: Jul 16, 2026

Published by: Ubiquity Press

In partnership with: Paradigm Publishing Services

Keywords:

prevalence,

diagnosed essential tremor,

electronic healthcare records

© 2026 Daniel Kratovil, Seung Yeon Jung, Sonia Stoica, Matthew Roy, Alia C. Stanciu, M. Cosmin Sandulescu, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 16 (2026): Issue 1

Prevalence of Diagnosed Essential Tremor Using Electronic Healthcare Records: A Population-Based Study in Northeast-Central Pennsylvania

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