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Risk of Cervical Spine Complications in Individuals with Cervical Dystonia Treated with Botulinum Toxin Therapy Cover

Risk of Cervical Spine Complications in Individuals with Cervical Dystonia Treated with Botulinum Toxin Therapy

Open Access
|May 2026

References

  1. Kilic-Berkmen G, Pirio Richardson S, Perlmutter JS, et al. Current Guidelines for Classifying and Diagnosing Cervical Dystonia: Empirical Evidence and Recommendations. Mov Disord Clin Pract. 2022;9:183190. DOI: 10.1002/mdc3.13376
  2. Wagle Shukla A, Gurrala A, Vedam-Mai V. Gait and balance in cervical dystonia and dystonic head tremor. Dystonia. 2023;2. DOI: 10.3389/dyst.2023.11231
  3. Smith SS, Stewart ME, Davies BM, Kotter MRN. The Prevalence of Asymptomatic and Symptomatic Spinal Cord Compression on Magnetic Resonance Imaging: A Systematic Review and Meta-analysis. Global Spine J. 2021;11:597607. DOI: 10.1177/2192568220934496
  4. Jankovic J, Leder S, Warner D, Schwartz K. Cervical dystonia: clinical findings and associated movement disorders. Neurology. 1991;41:10881091. DOI: 10.1212/WNL.41.7.1088
  5. Konrad C, Vollmer-Haase J, Anneken K, Knecht S. Orthopedic and neurological complications of cervical dystonia–review of the literature. Acta Neurol Scand. 2004;109:369373. DOI: 10.1111/j.1600-0404.2004.00281.x
  6. Chen PL, Wang PY. Spondylotic myelopathy in patients with cervical dystonia. J Chin Med Assoc. 2012;75:8183. DOI: 10.1016/j.jcma.2011.12.003
  7. Wong AS, Massicotte EM, Fehlings MG. Surgical treatment of cervical myeloradiculopathy associated with movement disorders: indications, technique, and clinical outcome. J Spinal Disord Tech. 2005;18 Suppl:S107114. DOI: 10.1097/01.bsd.0000128693.44276.86
  8. Krauss JK, Loher TJ, Pohle T, et al. Pallidal deep brain stimulation in patients with cervical dystonia and severe cervical dyskinesias with cervical myelopathy. J Neurol Neurosurg Psychiatry. 2002;72:249256. DOI: 10.1136/jnnp.72.2.249
  9. Hagenah JM, Vieregge A, Vieregge P. Radiculopathy and myelopathy in patients with primary cervical dystonia. Eur Neurol. 2001;45:236240. DOI: 10.1159/000052135
  10. Weigel R, Rittmann M, Krauss JK. Spontaneous craniocervical osseous fusion resulting from cervical dystonia. Case report. J Neurosurg 2001;95:115118. DOI: 10.3171/spi.2001.95.1.0115
  11. Al-Jishi A, Sreekantaswamy. Dystonia associated with atlantoaxial subluxation. Clin Neurol Neurosurg. 2000;102:233235. DOI: 10.1016/S0303-8467(00)00087-1
  12. Chawda SJ, Münchau A, Johnson D, et al. Pattern of premature degenerative changes of the cervical spine in patients with spasmodic torticollis and the impact on the outcome of selective peripheral denervation. J Neurol Neurosurg Psychiatry. 2000;68:465471. DOI: 10.1136/jnnp.68.4.465
  13. Dalvie S, Moore AP, Findlay GF. C1/C2 rotary subluxation due to spasmodic torticollis. J Neurol Neurosurg Psychiatry. 2000;69:135136. DOI: 10.1136/jnnp.69.1.135a
  14. Adler CH, Zimmerman RS, Lyons MK, Simeone F, Brin MF. Perioperative use of botulinum toxin for movement disorder-induced cervical spine disease. Mov Disord. 1996;11:7981. DOI: 10.1002/mds.870110114
  15. Defazio G, Lepore V, Melpignano C, Lamberti P, Livrea P, Ferrari E. Cervical radiculopathy following botulinum toxin therapy for cervical dystonia. Funct Neurol. 1993;8:193196.
  16. Polk JL, Maragos VA, Nicholas JJ. Cervical spondylotic myeloradiculopathy in dystonia. Arch Phys Med Rehabil. 1992;73:389392. DOI: 10.1016/0003-9993(92)90016-P
  17. Waterston JA, Swash M, Watkins ES. Idiopathic dystonia and cervical spondylotic myelopathy. J Neurol Neurosurg Psychiatry. 1989;52:14241426. DOI: 10.1136/jnnp.52.12.1424
  18. Loher TJ, Bärlocher CB, Krauss JK. Dystonic movement disorders and spinal degenerative disease. Stereotact Funct Neurosurg. 2006;84:111. DOI: 10.1159/000092681
  19. Marciniec M, Szczepańska-Szerej A, Popek-Marciniec S, Rejdak K. Pain incidence in cervical dystonia is determined by the disease phenotype. J Clin Neurosci. 2020;79:133136. DOI: 10.1016/j.jocn.2020.07.069
  20. Junker J, Berman BD, Hall J, et al. Quality of life in isolated dystonia: non-motor manifestations matter. J Neurol Neurosurg Psychiatry. 2021. DOI: 10.1136/jnnp-2020-325193
  21. Rosales RL, Cuffe L, Regnault B, Trosch RM. Pain in cervical dystonia: mechanisms, assessment and treatment. Expert Rev Neurother. 2021;21:11251134. DOI: 10.1080/14737175.2021.1984230
  22. Charles PD, Adler CH, Stacy M, et al. Cervical dystonia and pain: characteristics and treatment patterns from CD PROBE (Cervical Dystonia Patient Registry for Observation of OnabotulinumtoxinA Efficacy). J Neurol. 2014;261:13091319. DOI: 10.1007/s00415-014-7343-6
  23. Williams L, McGovern E, Kimmich O, et al. Epidemiological, clinical and genetic aspects of adult onset isolated focal dystonia in Ireland. Eur J Neurol. 2017;24:7381. DOI: 10.1111/ene.13133
  24. Kutvonen O, Dastidar P, Nurmikko T. Pain in spasmodic torticollis. Pain. 1997;69:279286. DOI: 10.1016/S0304-3959(96)03296-4
  25. Barbanti P, Fabbrini G, Pauletti C, Defazio G, Cruccu G, Berardelli A. Headache in cranial and cervical dystonia. Neurology. 2005;64:13081309. DOI: 10.1212/01.WNL.0000156909.13677.FF
  26. Wagle Shukla A. Basis of movement control in dystonia and why botulinum toxin should influence it? Toxicon. 2023;107251. DOI: 10.1016/j.toxicon.2023.107251
  27. de-la-Hoz-López D, Cuadrado ML, López-Valdés E, et al. Sensitization-Associated Symptoms and Neuropathic-like Features in Patients with Cervical Dystonia and Pain. J Clin Med. 2024;13. DOI: 10.3390/jcm13072134
  28. Wagle Shukla A, Chen R, Hu W. Pain control due to botulinum toxin therapy in cervical dystonia relates to the sensorimotor integration process. Dystonia. 2023;2. DOI: 10.3389/dyst.2023.11362
  29. Chiu SY, Patel B, Burns MR, et al. High-dose Botulinum Toxin Therapy: Safety, Benefit, and Endurance of Efficacy. Tremor Other Hyperkinet Mov (N Y). 2020;10. DOI: 10.5334/tohm.527
  30. Albanese A, Wissel J, Jost WH, et al. Pain Reduction in Cervical Dystonia Following Treatment with IncobotulinumtoxinA: A Pooled Analysis. Toxins (Basel). 2023;15. DOI: 10.3390/toxins15050333
  31. Marciniec M, Szczepańska-Szerej A, Kulczyński M, Sapko K, Popek-Marciniec S, Rejdak K. Pain in cervical dystonia and the antinociceptive effects of botulinum toxin: what is currently known? Rev Neurosci. 2019;30:771779. DOI: 10.1515/revneuro-2018-0119
  32. Mahajan A, Jankovic J, Marsh L, et al. Cervical dystonia and substance abuse. J Neurol. 2018;265:970975. DOI: 10.1007/s00415-018-8840-9
  33. Traynelis VC, Ryken T, Rodnitzky RL, Menezes AH. Botulinum toxin enhancement of postoperative immobilization in patients with cervical dystonia. Technical note. J Neurosurg. 1992;77:808809. DOI: 10.3171/jns.1992.77.5.0808
DOI: https://doi.org/10.5334/tohm.1203 | Journal eISSN: 2160-8288
Language: English
Page range: 31 - 31
Submitted on: Mar 17, 2026
Accepted on: Apr 23, 2026
Published on: May 20, 2026
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2026 Samyukta Senthil, Sanjeev Kumar, Aparna Wagle Shukla, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.