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Continued Dialogue about the Clinical Heterogeneity and Degenerative Pathology That Characterizes the Essential Tremors Cover

Continued Dialogue about the Clinical Heterogeneity and Degenerative Pathology That Characterizes the Essential Tremors

By: Elan D. Louis  
Open Access
|Mar 2026

References

  1. Khan MS, Khan SH. Longitudinal Intention Tremor Trajectories in Essential Tremor: A Comment. Tremor Other Hyperkinet Mov (N Y). 2026.
  2. Louis ED, Faust PL. Essential tremor pathology: neurodegeneration and reorganization of neuronal connections. Nat Rev Neurol. 2020;16(2):6983. DOI: 10.1038/s41582-019-0302-1
  3. Louis ED, Faust PL. Purkinje cell loss in essential tremor. Mov Disord. 2014;29(10):13291330. DOI: 10.1002/mds.25965
  4. Choe M, Cortes E, Vonsattel JG, et al. Purkinje cell loss in essential tremor: Random sampling quantification and nearest neighbor analysis. Mov Disord. 2016;31:393401. DOI: 10.1002/mds.26490
  5. Louis ED, Faust PL. Prevalence of Lewy pathology in essential tremor is twice as high as expected: A plausible explanation for the enhanced risk for Parkinson disease seen in essential tremor cases. J Neuropathol Exp Neurol. 2023;82(5):454455. DOI: 10.1093/jnen/nlad021
  6. Louis ED. Six Myths and Misconceptions about Essential Tremor. Tremor Other Hyperkinet Mov (N Y). 2024;14:49. DOI: 10.5334/tohm.948
  7. Louis ED, Martuscello RT, Gionco JT, et al. Histopathology of the cerebellar cortex in essential tremor and other neurodegenerative motor disorders: comparative analysis of 320 brains. Acta Neuropathol. 2023;145(3):265283. DOI: 10.1007/s00401-022-02535-z
  8. Lenka A, Louis ED. Developing a Staging Scheme for Essential Tremor: A Discussion of Organizing Principles. Tremor Other Hyperkinet Mov (N Y). 2023;13:43. DOI: 10.5334/tohm.812
  9. Louis ED. Essential tremors: a family of neurodegenerative disorders? Arch Neurol. 2009;66(10):12021208. DOI: 10.1001/archneurol.2009.217
DOI: https://doi.org/10.5334/tohm.1199 | Journal eISSN: 2160-8288
Language: English
Submitted on: Mar 10, 2026
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Accepted on: Mar 11, 2026
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Published on: Mar 30, 2026
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2026 Elan D. Louis, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.