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Pallidal Deep Brain Stimulation for Tremor Control in a Child with Juvenile DNAJC6-Associated Parkinsonism Cover

Pallidal Deep Brain Stimulation for Tremor Control in a Child with Juvenile DNAJC6-Associated Parkinsonism

Open Access
|May 2026

References

  1. Kurian MA, DNAJC6 Parkinson Disease AL, Adam F, Feldman MP, Mirzaa J. NIM Citation. DNAJC6.
  2. Ng J, Cortès-Saladelafont E, Abela L, et al. DNAJC6 Mutations Disrupt Dopamine Homeostasis in Juvenile Parkinsonism-Dystonia. Movement Disorders. 2020;35(8):13571368. DOI: 10.1002/mds.28063
  3. Garza-Brambila, D, Esparza-Hernández CN, Ramírez-Zenteno J, Martínez-Ramírez D. Juvenile Dystonia-Parkinsonism Due to DNAJC6 Mutation. Mov Disord Clin Pract. 2021;8(S1):S26S28. DOI: 10.1002/mdc3.13294
  4. Edvardson S, Cinnamon Y, Ta-Shma A, et al. A deleterious mutation in DNAJC6 encoding the neuronal-specific clathrin-uncoating Co-chaperone auxilin, is associated with juvenile parkinsonism. PLoS One. 2012;7(5). DOI: 10.1371/journal.pone.0036458
  5. Richards S, Aziz N, Bale S, et al. Standards and Guidelines for the Interpretation of Sequence Variants: A Joint Consensus Recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. 2015;17(5):405. DOI: 10.1038/gim.2015.30
  6. Neudorfer C, Butenko K, Oxenford S, et al. Lead-DBS v3.0: Mapping deep brain stimulation effects to local anatomy and global networks. Neuroimage. 2023;268:119862. DOI: 10.1016/j.neuroimage.2023.119862
  7. Edlow BL, Mareyam A, Horn A, et al. 7 Tesla MRI of the ex vivo human brain at 100 micron resolution. Sci Data. 2019;6(1). DOI: 10.1038/s41597-019-0254-8
  8. Mittal SO. Levodopa responsive-generalized dystonic spells and moaning in DNAJC6 related Juvenile Parkinson’s disease. Parkinsonism Relat Disord. 2020;81:188189. DOI: 10.1016/j.parkreldis.2020.10.046
  9. Köroğlu Ç, Baysal L, Cetinkaya M, Karasoy H, Tolun A. DNAJC6 is responsible for juvenile parkinsonism with phenotypic variability. Parkinsonism Relat Disord. 2013;19(3):320324. DOI: 10.1016/j.parkreldis.2012.11.006
  10. Ray S, Padmanabha H, Mahale R, Mailankody P, Arunachal G. DNAJC6 mutation causing cranial-onset dystonia with tremor dominant levodopa non-responsive parkinsonism: A novel phenotype. Parkinsonism Relat Disord. 2021;89:13. DOI: 10.1016/j.parkreldis.2021.06.013
  11. Olgiati S, Quadri M, Fang M, et al. DNAJC6 Mutations Associated with Early-Onset Parkinson’s Disease. Ann Neurol. 2016;79(2):244256. DOI: 10.1002/ana.24553
  12. Zhang J, Li J, Chen F, Liu X, Jiang C, Hu X, et al. STN versus GPi deep brain stimulation for dyskinesia improvement in advanced Parkinson’s disease: A meta-analysis of randomized controlled trials. Clinical Neurology and Neurosurgery. Elsevier B.V.; 2021;201. DOI: 10.1016/j.clineuro.2020.106450
  13. Li CY, Ou RW, Chen YP, et al. Mutation Analysis of DNAJC6 Family for Early-Onset Parkinson’s Disease in a Chinese Cohort. Movement Disorders. 2020;35(11):20682076. DOI: 10.1002/mds.28203
  14. Manifield, J, Bogdanovic, M, Sarangmat, N, Scotton, S, Green, AL, Fitzgerald, J. Homozygous DNAJC6 Mutated Juvenile Onset Dystonia Treated with Bilateral Globus Pallidus Internus Deep Brain Stimulation. Mov Disord Clin Pract. Published online 2024. DOI: 10.1002/mdc3.14300
DOI: https://doi.org/10.5334/tohm.1187 | Journal eISSN: 2160-8288
Language: English
Page range: 32 - 32
Submitted on: Feb 11, 2026
Accepted on: Feb 13, 2026
Published on: May 21, 2026
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2026 Katerina Bernardi, Deyana Valcheva, Rene Marquez Franco, Michael T. Barbe, Jochen Wirths, Anne Koy, Moritz Thiel, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.