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Uncovering Cognitive Subtypes in Essential Tremor: A Data-Driven Clustering Approach in Cognitively Normal Individuals Cover

Uncovering Cognitive Subtypes in Essential Tremor: A Data-Driven Clustering Approach in Cognitively Normal Individuals

Open Access
|Nov 2025

References

  1. 1Pedrosa DJ, Nelles C, Brown P, Volz LJ, Pelzer EA, Tittgemeyer M, Brittain JS, Timmermann L. The differentiated networks related to essential tremor onset and its amplitude modulation after alcohol intake. Exp Neurol. 2017;297:5061. DOI: 10.1016/j.expneurol.2017.07.013
  2. 2Louis ED, Ferreira JJ. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord. 2010;25(5):53441. DOI: 10.1002/mds.22838
  3. 3Louis ED, Okun MS. It is time to remove the ‘benign’ from the essential tremor label. Parkinsonism Relat Disord. 2011;17(7):51620. DOI: 10.1016/j.parkreldis.2011.03.012
  4. 4Cersonsky TEK, Diaz DT, Kellner S, Hickman R, Zdrodowska MA, Monin JK, Louis ED. Enfeeblement in Elders with Essential Tremor: Characterizing the Phenomenon and Its Role in Caregiver Burden. Tremor Other Hyperkinet Mov (NY). 2019;9. DOI: 10.5334/tohm.461
  5. 5Melchert S, Steiner OL, Kupper C, Lochmann H, Wyrobnik M, Klostermann F. Social cognitive impact of essential tremor. Sci Rep. 2025;15(1):23591. DOI: 10.1038/s41598-025-08402-7
  6. 6Bermejo-Pareja F, Louis ED, Benito-León J. Neurological Disorders in Central Spain (NEDICES) Study Group. Risk of incident dementia in essential tremor: a population-based study. Mov Disord. 2007;22(11):157380. DOI: 10.1002/mds.21553
  7. 7Thawani SP, Schupf N, Louis ED. Essential tremor is associated with dementia: prospective population-based study in New York. Neurology. 2009;73(8):6215. DOI: 10.1212/WNL.0b013e3181b389f1
  8. 8Ghanem A, Berry DS, Burkes A, Grill N, Hall TM, Hart KA, Hernandez NC, Chapman S, Sharma VD, Huey ED, Cosentino SA, Louis ED. Prevalence of and Annual Conversion Rates to Mild Cognitive Impairment and Dementia: Prospective, Longitudinal Study of an Essential Tremor Cohort. Ann Neurol. 2024;95(6):11931204. DOI: 10.1002/ana.26927
  9. 9Ratajska AM, Lopez FV, Kenney L, Jacobson C, Foote KD, Okun MS, Bowers D. Cognitive subtypes in individuals with essential tremor seeking deep brain stimulation. Clin Neuropsychol. 2022;36(7):17051727. DOI: 10.1080/13854046.2021.1882578
  10. 10Cersonsky TEK, Kellner S, Chapman S, Huey ED, Louis ED, Cosentino S. Profiles of Normal Cognition in Essential Tremor. J Int Neuropsychol Soc. 2020;26(2):197209. DOI: 10.1017/S1355617719001140
  11. 11Frey BJ, Dueck D. Clustering by passing messages between data points. Science. 2007;315(5814):9726. DOI: 10.1126/science.1136800
  12. 12Pelagi A, Camastra C, Sarica A. Social, emotional, and personality factors shape four psychological well-being profiles: A clustering approach in young adults with affinity propagation algorithm. Appl Psychol Health Well Being. 2025;17(5):e70072. DOI: 10.1111/aphw.70072
  13. 13Madhulatha TS. An overview on clustering methods. IOSR Journal of Engineering. 2012;02(04):719725. DOI: 10.9790/3021-0204719725
  14. 14Sarica A, Vaccaro MG, Quattrone A, Quattrone A. A Novel Approach for Cognitive Clustering of Parkinsonisms through Affinity Propagation. Algorithms. 2021;14(2):49. DOI: 10.3390/a14020049
  15. 15Bhatia KP, Bain P, Bajaj N, Elble RJ, Hallett M, Louis ED, Raethjen J, Stamelou M, Testa CM, Deuschl G. Tremor Task Force of the International Parkinson and Movement Disorder Society. Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society. Mov Disord. 2018;33(1):7587. DOI: 10.1002/mds.27121
  16. 16Novellino F, Cherubini A, Chiriaco C, Morelli M, Salsone M, Arabia G, Quattrone A. Brain iron deposition in essential tremor: a quantitative 3-Tesla magnetic resonance imaging study. Mov Disord. 2013;28(2):196200. DOI: 10.1002/mds.25263
  17. 17Fahn S, Tolosa E, Marín C. Clinical rating scale for tremor. Clinical rating scale for tremor. Parkinson’s Dis Mov Disord. 1993;2:271280.
  18. 18Novellino F, Saccà V, Salsone M, Nicoletti G, Quattrone A, Chiriaco C, Madrigal JLM, Quattrone A. Cognitive functioning in essential tremor without dementia: a clinical and imaging study. Neurol Sci. 2022;43(8):48114820. DOI: 10.1007/s10072-022-06045-4
  19. 19Magni E, Binetti G, Bianchetti A, Rozzini R, Trabucchi M. Mini-Mental State Examination: a normative study in Italian elderly population. Eur J Neurol. 1996;3(3):198202. DOI: 10.1111/j.1468-1331.1996.tb00423.x
  20. 20Appollonio I, Leone M, Isella V, Piamarta F, Consoli T, Villa ML, et al. The Frontal Assessment Battery (FAB): normative values in an Italian population sample. Neurological Sciences. 2005;26(2):10816. DOI: 10.1007/s10072-005-0443-4
  21. 21Caffarra P, Vezzadini G, Dieci F, Zonato F, Venneri A. Modified Card Sorting Test: Normative Data. J Clin Exp Neuropsychol. 2004;26(2):24650. DOI: 10.1076/jcen.26.2.246.28087
  22. 22Wechsler D. Manual for the Wechsler Adult Intelligence Scale Revised. New York, NY: Psychological Corporation; 1981.
  23. 23Carlesimo GA, Caltagirone C, Gainotti G. Mental Deterioration Battery: Normative data, diagnostic reliability and qualitative analyses of cognitive impairment. The Group for the Standardization of the Mental Deterioration Battery. Eur Neurol. 1996;36:378384. DOI: 10.1159/000117297
  24. 24Benton AL, Varney NR, Hamsher KD. Visuospatial judgment. A clinical test. Arch Neurol. 1978;35(6):3647. DOI: 10.1001/archneur.1978.00500300038006
  25. 25Token test in Italian standardization and classification of Neuropsychological tests. The Italian Group on the Neuropsychological Study of Aging. Ital J Neurol Sci. 1987;8:120123.
  26. 26Salsone M, Arabia G, Manfredini L, Quattrone A, Chiriaco C, Vescio B, Sturniolo M, Morelli M, Nistico’ R, Novellino F, Gambardella A, Quattrone A. REM-Sleep Behavior Disorder in Patients With Essential Tremor: What Is Its Clinical Significance? Front Neurol. 2019;10:315. DOI: 10.3389/fneur.2019.00315
  27. 27Beck AT, Steer R. Depression Inventory Scoring Manual. New York, NY: The Psychological Corporation; 1987.
  28. 28Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol. 1959;32:5055. DOI: 10.1111/j.2044-8341.1959.tb00467.x
  29. 29Brusco MJ, Steinley D, Hoffman M, Davis-Stober C, Wasserman S. On Ising models and algorithms for the construction of symptom networks in psychopathological research. Psychol Methods. 2019;24(6):735753. DOI: 10.1037/met0000207
  30. 30American Psychiatric Association. Diagnostic and statistical manual of mental disorders (5th ed., text rev.); 2022. DOI: 10.1176/appi.books.9780890425787
  31. 31Passamonti L, Novellino F, Cerasa A, Chiriaco C, Rocca F, Matina MS, Fera F, Quattrone A. Altered cortical-cerebellar circuits during verbal working memory in essential tremor. Brain. 2011;134(Pt 8):227486. DOI: 10.1093/brain/awr164
  32. 32Campbell JM, Ballard J, Duff K, Zorn M, Moretti P, Alexander MD, Rolston JD. Balance and cognitive impairments are prevalent and correlated with age in presurgical patients with essential tremor. Clin Park Relat Disord. 2022;6:100134. DOI: 10.1016/j.prdoa.2022.100134
  33. 33Benito-León J, Louis ED, Mitchell AJ, Bermejo-Pareja F. Elderly-onset essential tremor and mild cognitive impairment: a population-based study (NEDICES). J Alzheimers Dis. 2011;23(4):72735. DOI: 10.3233/JAD-2011-101572
  34. 34Baddeley AD. Exploring the central executive. Q J ExpPsychol. 1996;49A:528. DOI: 10.1080/027249896392784
  35. 35Janicki SC, Cosentino S, Louis ED. The cognitive side of essential tremor: what are the therapeutic implications? Ther Adv Neurol Disord. 2013;6(6):35368. DOI: 10.1177/1756285613489591
  36. 36Destrebecq V, Naeije G. Cognitive impairment in essential tremor assessed by the cerebellar cognitive affective syndrome scale. Front Neurol. 2023;14:1224478. DOI: 10.3389/fneur.2023.1224478
  37. 37Bagarinao E, Maesawa S, Kato S, Mutoh M, Ito Y, Ishizaki T, Tanei T, Tsuboi T, Suzuki M, Watanabe H, Hoshiyama M, Isoda H, Katsuno M, Sobue G, Saito R. Cerebellar and thalamic connector hubs facilitate the involvement of visual and cognitive networks in essential tremor. Parkinsonism Relat Disord; 121:106034. DOI: 10.1016/j.parkreldis.2024.106034
  38. 38Kim JS, Song IU, Shim YS, Park JW, Yoo JY, Kim YI, Lee KS. Cognitive Impairment in Essential Tremor without Dementia. J Clin Neurol. 2009;5(2):814. DOI: 10.3988/jcn.2009.5.2.81
  39. 39Novellino F, Vasta R, Saccà V, Nisticò R, Morelli M, Arabia G, Chiriaco C, Barbagallo G, Nicoletti G, Salsone M, Quattrone A. Hippocampal impairment in patients with Essential Tremor. Parkinsonism Relat Disord. 2020;72:5661. DOI: 10.1016/j.parkreldis.2020.02.006
  40. 40Pietracupa S, Bologna M, Tommasin S, Berardelli A, Pantano P. The Contribution of Neuroimaging to the Understanding of Essential Tremor Pathophysiology: a Systematic Review. Cerebellum. 2022;21(6):10291051. DOI: 10.1007/s12311-021-01335-7
  41. 41Bhalsing KS, Kumar KJ, Saini J, Yadav R, Gupta AK, Pal PK. White matter correlates of cognitive impairment in essential tremor. AJNR Am J Neuroradiol. 2015;36(3):44853. DOI: 10.3174/ajnr.A4138
  42. 42Shang Y, Chen X, Ai M, Gao X, Dai S, Zhao M, Yang C, Wang L, Zhang J, Zhong L, Bao T, Liu X. Association of Essential Tremor With Dementia and Affective Disorders: A Meta-Analysis. Front Neurol. 2022;13:842732. DOI: 10.3389/fneur.2022.842732
  43. 43Hashida M, Maesawa S, Mizuno S, Kato S, Ito Y, Mutoh M, Suzuki T, Ishizaki T, Tanei T, Tsuboi T, Suzuki M, Nakatsubo D, Tsugawa T, Bagarinao E, Wakabayashi T, Katsuno M, Saito R. Evaluation of mild cognitive impairment in older patients with essential tremor. Parkinsonism Relat Disord. 2025;131:107228. DOI: 10.1016/j.parkreldis.2024.107228
  44. 44Benito-León J, Lapeña-Motilva J, Ghosh R, Giménez de Béjar V, Benito-Rodríguez CM, Bermejo-Pareja F. Essential Tremor and Mortality in Older Adults: The Role of Word Recall, a Measure of Episodic Memory, in a 23-Year Follow-Up Study. J. Clin. Med. 2025;14:1160. DOI: 10.3390/jcm14041160
DOI: https://doi.org/10.5334/tohm.1090 | Journal eISSN: 2160-8288
Language: English
Submitted on: Aug 9, 2025
Accepted on: Oct 23, 2025
Published on: Nov 5, 2025
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2025 Alessia Sarica, Camilla Calomino, Rita Nisticò, Maria Salsone, Andrea Quattrone, Aldo Quattrone, Fabiana Novellino, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.