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Corpus Callosum Structural Alterations in Essential Tremor with and Without Resting Tremor: A Multimodal MRI Study Cover

Corpus Callosum Structural Alterations in Essential Tremor with and Without Resting Tremor: A Multimodal MRI Study

Open Access
|Oct 2025

References

  1. 1Critchley M. Observations on essential (heredofamilial) tremor. Brain. 1949;72(2):113139. DOI: 10.1093/brain/72.2.113
  2. 2Deuschl G, Elble RJ. The pathophysiology of essential tremor. Neurology. 2000;54(11 Suppl 4):1420.
  3. 3Cohen O, Pullman S, Jurewicz E, Watner D, Louis ED. Rest tremor in patients with essential tremor: Prevalence, clinical correlates, and electrophysiologic characteristics. Archives of Neurology. 2003;60(4):405410. DOI: 10.1001/archneur.60.3.405
  4. 4Erro R, Sorrentino C, Russo M, Barone P. Essential tremor plus rest tremor: current concepts and controversies. Journal of Neural Transmission. 2022;129(7):835846. DOI: 10.1007/s00702-022-02516-2
  5. 5Arabia G, Lupo A, Manfredini LI, Vescio B, Nisticò R, Barbagallo G, et al. Clinical, electrophysiological, and imaging study in essential tremor–Parkinson’s disease syndrome. Parkinsonism Relat Disord. 2018;56:2026. DOI: 10.1016/j.parkreldis.2018.06.005
  6. 6Bhatia KP, Bain P, Bajaj N, Elble RJ, Hallett M, Louis ED, et al. Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society. Movement Disorders. 2018;33(1):7587. DOI: 10.1002/mds.27121
  7. 7Louis ED, Bares M, Benito-Leon J, Fahn S, Frucht SJ, Jankovic J, Ondo WG, Pal PK, Tan EK. Essential tremor-plus: a controversial new concept. The Lancet. Neurology, 2020;19(3):266270. DOI: 10.1016/S1474-4422(19)30398-9
  8. 8Gionco JT, Hartstone WG, Martuscello RT, Kuo SH, Faust PL, Louis ED. Essential Tremor versus “ET-plus”: A Detailed Postmortem Study of Cerebellar Pathology. Cerebellum (London, England). 2021;20(6):904912. DOI: 10.1007/s12311-021-01263-6
  9. 9Novellino F, Nicoletti G, Cherubini A, et al. Cerebellar involvement in essential tremor with and without resting tremor: a diffusion tensor imaging study. Parkinsonism & Related Disorders. 2016;27:6166. DOI: 10.1016/j.parkreldis.2016.03.022
  10. 10Caligiuri ME, Arabia G, Barbagallo G, et al. Structural connectivity differences in essential tremor with and without resting tremor. Journal of Neurology. 2017;264(9):18651874. DOI: 10.1007/s00415-017-8553-5
  11. 11Bianco MG, Quattrone A, Sarica A, et al. Cortical involvement in essential tremor with and without rest tremor: a machine learning study. Journal of Neurology. 2023;270(8):40044012. DOI: 10.1007/s00415-023-11747-6
  12. 12Sarica A, Gramigna V, Arcuri F, Crasà M, Calomino C, Nisticò R, et al. Differential tractography identifies a distinct pattern of white matter alterations in essential tremor with or without resting tremor. Neuroimage Clin. 2025;45:103734. DOI: 10.1016/j.nicl.2025.103734
  13. 13Benito-León J, Mato-Abad V, Louis ED, et al. White matter microstructural changes are related to cognitive dysfunction in essential tremor. Scientific Reports. 2017;7(1):2978. DOI: 10.1038/s41598-017-02596-1
  14. 14Saini J, Bagepally BS, Bhatt MD, Chandran V, Bharath RD, Prasad C, et al. Diffusion tensor imaging: tract based spatial statistics study in essential tremor. Parkinsonism & Related Disorders. 2012;18(5):477482. DOI: 10.1016/j.parkreldis.2012.01.006
  15. 15Felten DL, O’Banion MK, Maida ME. Netter’s atlas of neuroscience. Elsevier Health Sciences; 2015.
  16. 16Bledsoe IO, Stebbins GT, Merkitch D, Goldman JG. White matter abnormalities in the corpus callosum with cognitive impairment in Parkinson disease. Neurology. 2018;91(24):e2244e2255. DOI: 10.1212/WNL.0000000000006646
  17. 17Teipel SJ, Bayer W, Alexander GE, et al. Progression of corpus callosum atrophy in Alzheimer disease. Archives of Neurology. 2002;59(2):243248. DOI: 10.1001/archneur.59.2.243
  18. 18Novellino F, Arabia G, Bagnato A, Cascini GL, Salsone M, Nicoletti G, et al. Combined use of DAT-SPECT and cardiac MIBG scintigraphy in mixed tremors. Mov Disord. 2009;24(15):22422248. DOI: 10.1002/mds.22771
  19. 19Fahn S, Tolosa E, Marín C. Clinical rating scale for tremor. Parkinson’s Disease and Movement Disorders. 1993;2:271280.
  20. 20Nisticò R, Pirritano D, Salsone M, Novellino F, Del Giudice F, Morelli M, Trotta M, Bilotti G, Condino F, Cherubini A, Valentino P, Quattrone A. Synchronous pattern distinguishes resting tremor associated with essential tremor from rest tremor of Parkinson’s disease. Parkinsonism & related disorders. 2011;17(1):3033. DOI: 10.1016/j.parkreldis.2010.10.006
  21. 21Measso G, Cavarzeran F, Zappalà G, Lebowitz BD, Crook TH, Pirozzolo FJ, et al. The mini mental state examination: normative study of an Italian random sample. Developmental Neuropsychology. 1993;9(2):7785. DOI: 10.1080/87565649109540545
  22. 22Lezak MD. Neuropsychological assessment. Oxford University Press; 2004.
  23. 23Schmidt M. Rey auditory verbal learning test. Western Psychological Services. 1996;1 125.
  24. 24Caligiuri ME, Labate A, Cherubini A, Mumoli L, Ferlazzo E, Aguglia U, et al. Integrity of the corpus callosum in patients with benign temporal lobe epilepsy. Epilepsia. 2016;57(4):590596. DOI: 10.1111/epi.13339
  25. 25Adamson CL, Wood AG, Chen J, et al. Thickness profile generation for the corpus callosum using Laplace’s equation. Human Brain Mapping. 2011;32(12):21312140. DOI: 10.1002/hbm.21174
  26. 26Nahab F, Shen Q, Wright C, et al. Brain MRI morphometric changes in essential tremor versus controls. Imaging in Medicine. 2013;5(5):427.
  27. 27Beaulieu C. The basis of anisotropic water diffusion in the nervous system–a technical review. NMR in Biomedicine. 2002;15(7 8):435455. DOI: 10.1002/nbm.782
  28. 28Aung WY, Mar S, Benzinger TL. Diffusion tensor MRI as a biomarker in axonal and myelin damage. Imaging in Medicine. 2013;5(5):427. DOI: 10.2217/iim.13.49
  29. 29Lynn JD, Anand C, Arshad M, Homayouni R, Rosenberg DR, Ofen N, Raz N, Stanley JA. Microstructure of Human Corpus Callosum across the Lifespan: Regional Variations in Axon Caliber, Density, and Myelin Content. Cerebral cortex (New York, N.Y. : 1991). 2021;31(2):10321045. DOI: 10.1093/cercor/bhaa272
  30. 30Aboitiz F, Scheibel AB, Fisher RS, Zaidel E. Fiber composition of the human corpus callosum. Brain research. 1992;598(1–2):143153. DOI: 10.1016/0006-8993(92)90178-C
  31. 31Pietracupa S, Bologna M, Bharti K, Pasqua G, Tommasin S, Elifani F, et al. White matter rather than gray matter damage characterizes essential tremor. European Radiology. 2019;29:66346642. DOI: 10.1007/s00330-019-06267-9
  32. 32Pelzer EA, Nelles C, Pedrosa DJ, et al. Structural differences in impaired verbal fluency in essential tremor patients compared to healthy controls. Brain and Behavior. 2017;7(7):e00722. DOI: 10.1002/brb3.722
  33. 33Nestrasil I, Svatkova A, Rudser KD, Chityala R, Wakumoto A, Mueller BA, et al. White matter measures correlate with essential tremor severity—a pilot diffusion tensor imaging study. Brain and Behavior. 2018;8(8):e01039. DOI: 10.1002/brb3.1039
  34. 34Bergamino M, Aslam S, Knittel JJ, Alhilali L, Stokes AM. White matter microstructural differences between essential tremor and Parkinson disease, evaluated using advanced diffusion MRI biomarkers. Journal of Integrative Neuroscience. 2023;22(5):114. DOI: 10.31083/j.jin2205114
  35. 35Angelini L, Paparella G, De Biase A, Maraone A, Panfili M, Berardelli I, … Bologna M. Longitudinal study of clinical and neurophysiological features in essential tremor. European Journal of Neurology. 2023;30(3):631640. DOI: 10.1111/ene.15650
  36. 36Louis ED, Huey ED, Cosentino S. Features of “ET plus” correlate with age and tremor duration:“ET plus” may be a disease stage rather than a subtype of essential tremor. Parkinsonism & related disorders. 2021;91:4247. DOI: 10.1016/j.parkreldis.2021.08.017
  37. 37Iglesias-Hernandez D, Delgado N, McGurn M, Huey ED, Cosentino S, Louis ED. “ET Plus”: instability of the diagnosis during prospective longitudinal follow-up of essential tremor cases. Frontiers in neurology. 2021;12:782694. DOI: 10.3389/fneur.2021.782694
  38. 38Nicoletti V, Cecchi P, Frosini D, Pesaresi I, Fabbri S, Diciotti S, … Ceravolo R. Morphometric and functional MRI changes in essential tremor with and without resting tremor. Journal of neurology. 2015;262(3):719728. DOI: 10.1007/s00415-014-7626-y
  39. 39Prasad S, Rastogi B, Shah A, Bhalsing KS, Ingalhalikar M, Saini J, … Pal PK. DTI in essential tremor with and without rest tremor: Two sides of the same coin? Movement disorders: official journal of the Movement Disorder Society. 2018;33(11):18201821. DOI: 10.1002/mds.27459
  40. 40Raz N, Lindenberger U, Rodrigue KM, et al. Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cerebral Cortex. 2005;15(11):16761689. DOI: 10.1093/cercor/bhi044
DOI: https://doi.org/10.5334/tohm.1083 | Journal eISSN: 2160-8288
Language: English
Submitted on: Aug 1, 2025
Accepted on: Oct 12, 2025
Published on: Oct 21, 2025
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2025 Valerio Riccardo Aquila, Maria Celeste Bonacci, Maria Eugenia Caligiuri, Rita Nisticò, Maria Salsone, Andrea Quattrone, Aldo Quattrone, Fabiana Novellino, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.