Figure 1
Cumulative number of samples stored in the Hannover Unified Biobank (HUB). a) The cumulative number of liquid samples stored in the HUB from 2008 to 2019 divided in blood and its derivatives, urine, cells and other biomaterials is shown. b) The cumulative number of tissue samples stored in the HUB, Institute of Pathology from 2013 to 2019 divided in FFPE and frozen samples is shown.
Figure 2
Workflow monitoring for collection, processing, storage and retrieving of liquid samples and derivatives in the HUB.
Figure 3
HUB basic data set. The HUB basic data set is collected together with all samples stored in the HUB. Further project specific clinical data are collected.
Figure 4
Statistics of primary sample transports from different sites of the MHH campus to the HUB (2018/2019) managed with an in-house developed web application a) Delivery of over 16.000 primary samples was managed with the web application in 2019. b) In 2019 over 2.400 deliveries were carried out with an average of 6.7 samples per delivery. c) 91% (average of 2018 and 2019) of the primary samples deliveries managed with the sample pickup tool arrive in the HUB in less than one hour.
| CONSORTIA | FUNDER | DESCRIPTION | GRANT REFERENCE NUMBER |
|---|---|---|---|
| German Center for Lung Research (DZL) | Federal Ministry of Education and Research (BMBF) | Network which links scientists at five locations in Germany and focuses on eight disease areas in lung research. | 82DZL002A1 |
| German Center of Infection Research (DZIF) Transpant Cohort | Federal Ministry of Education and Research (BMBF) | The DZIF transplantation cohort is part of the research area “Infections in immunocompromised hosts” at the DZIF | DZIF-TTU 07.701 |
| German Biobank Alliance (GBA) | Federal Ministry of Education and Research (BMBF) | Network for the harmonization of Biobanks in Germany. Partners establish uniform quality standards and make their biomaterials available for biomedical research throughout Europe | 01EY1706 |
| Collaborative Research Centres (SFB 209) | German Research Foundation (DFG) | Network with the focus on new mechanistic and therapeutic concepts for liver cancer in a solid tumor model | TRR209/1 |
| RESIST | German Research Foundation (DFG) | Excellence cluster with the focus on infections in the immunocompromised host | EXC 2155/1 |
| GAIN | Federal Ministry of Education and Research (BMBF) | Network with the focus on rare autoimmune diseases | 01GM1910E |
| DZIF ZIFCO | Federal Ministry of Education and Research (BMBF) | The ntegrated infection research cohort ZIFCO is an additional study within the German national cohort health study with focus on the correlation between acute, transient infections and chronic diseases | TI 09.903_00 |
| DZIF HBV Cure | Federal Ministry of Education and Research (BMBF) | DZIF cohort with the focus on chronic hepatitis B virus infection | TTU 05.806_01 |
| DIGIT-HF | Federal Ministry of Education and Research (BMBF) | DIGIT HF is a study for the therapy of cardiac insufficiency with digoxin | 01KG1303 |
| Neocyst | Federal Ministry of Education and Research (BMBF) | NEOCYST is a multicenter, interdisciplinary network of clinicians and scientists exploring early onset cystic kidney diseases | 01GM1903H |
| KFO 311 | German Research Foundation (DFG) | Register of patients who are treated with a support system due to an acute or terminal failure of the heart or lung | IL 53/13-1 |
| Fraunhofer biobank harmonisation | Fraunhofer-Gesellschaft zur Förd.der angewandten Forschung e.V. | The Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), a strategic network of the Fraunhofer Society with their core institutes IME-TMP, IZI and ITEM, set up a harmonization project to establish a joint biobank infrastructure according to German Biobank Alliance (GBA) standards and modern biobanking demands, supported by the Hannover Unified Biobank (HUB). | n.a. |
| INDIRA | Ministry for Science and Culture of Lower Saxony | Network with focus on severe RSV infections in children | ZN3437 |
| ImSAVAR | Innovative Medicines Initiative (EU-IMI) | Consortium with focus on the development of nonclinical assessment strategies of immunomodulatory therapies | 853988- imSAVAR-H2020-JTI-IMI2 |
| Hearing for all | German Research Foundation (DFG) | Excellence cluster with the focus on improvement of individualized hearing diagnostics and supply of technical | EXC 2177/1 |
| COVID-19 Biobank | Ministry for Science and Culture of Lower Saxony | Implementation of a COVID-19 cohort for SARS-CoV-2 related research projects | 14-76103-184 CORONA-1/20 |