The Assistance Publique Hôpitaux de Marseille’s Biobank

Etienne Dougy; Dominique Figarella-Branger; Pierre-Emmanuel Morange; Annachiara De Sandre-Giovannoli; Bruno Lacarelle; Karine Bertaux; Karine Pedeillier; Noémie Saut; Carine Jiguet-Jiglaire; Soutsakhone Tong; Karine Achache

doi:10.5334/ojb.63

Abstract

The biobank of the Assistance Publique Hôpitaux de Marseille (AP-HM) works as a multi-site biobank around one Quality Management System. The biobank works on the collection, preparation, storage and release of biological resources and their associated data. It receives tissue samples for neoplasms, DNA and cells for rare genetic diseases and blood samples for hematological and cardiovascular diseases. These samples are provided and classified by experts of different domains; the samples are under strict technical protocols with appropriate clinical data. This wide range of sample types, diseases and services allows collaborations with public or private laboratories to customize research projects or therapeutic trials.

Funding statement: The AP-HM biobank is supported by the French government’s MIG grant, intended to cover part of its annual cost based on its annual activity, valorization of released samples and funds from the AP-HM.

References

Suchon P, et al. Common Risk Factors Add to Inherited Thrombophilia to Predict Venous Thromboembolism Risk in Families. TH Open. 2019; 03(01): e28–e35. DOI: 10.1055/s-0039-1677807
Open DOI Search in Google Scholar Back to article
Germain M, et al. Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism. Am. J. Hum. Genet. 2015; 96: 532–542. DOI: 10.1016/j.ajhg.2015.01.019
Open DOI Search in Google Scholar Back to article
Elouej S, Beleza-Meireles A, Caswell R, Colclough K, Ellard S, Desvignes JP, Béroud C, Lévy N, Mohammed S, De Sandre-Giovannoli A. Exome sequencing reveals a de novo POLD1 mutation causing phenotypic variability in mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome (MDPL). Metabolism. 2017 Jun; 71: 213–225. DOI: 10.1016/j.metabol.2017.03.011
Open DOI Search in Google Scholar Back to article
Harhouri K, Navarro C, Depetris D, Mattei MG, Nissan X, Cau P, De Sandre-Giovannoli A, Lévy N. MG132-induced progerin clearance is mediated by autophagy activation and splicing regulation. EMBO Mol Med. 2017 Sep; 9(9): 1294–1313. DOI: 10.15252/emmm.201607315
Open DOI Search in Google Scholar Back to article
Renard D, Fourcade G, Milhaud D, Bessis D, Esteves-Vieira V, Boyer A, Roll P, Bourgeois P, Levy N, De Sandre-Giovannoli A. Novel LMNA mutation in atypical Werner syndrome presenting with ischemic disease. Stroke. 2009 Feb; 40(2): e11–4. DOI: 10.1161/STROKEAHA.108.531780
Open DOI Search in Google Scholar Back to article
De Sandre-Giovannoli A, Bernard R, Cau P, Navarro C, Amiel J, Boccaccio I, Lyonnet S, Stewart CL, Munnich A, Le Merrer M, Lévy N. Lamin a truncation in Hutchinson-Gilford progeria. Science. 2003 Jun 27; 300(5628): 2055. DOI: 10.1126/science.1084125
Open DOI Search in Google Scholar Back to article
Bacquet J, Stojkovic T, Boyer A, Martini N, Audic F, Chabrol B, Delague V, Levy N, Bonello-Palot N, et al. Molecular diagnosis of inherited peripheral neuropathies by targeted next-generation sequencing: molecular spectrum delineation. BMJ Open. 2018 Oct 28; 8(10): e021632. DOI: 10.1136/bmjopen-2018-021632
Open DOI Search in Google Scholar Back to article
Chabannon C, Honstettre A, Daufresne L-M, Martin P-M, Bonnetaud C, Birtwisle-Peyrottes I, Romain S, Achache K, Mery O, Bordonne O, et al. Publication of biological samples collections catalogues by tumor banks. Bull. Cancer. 2010; 97: 181–189. DOI: 10.1684/bdc.2009.0963
Open DOI Search in Google Scholar Back to article
Hofman V, Ilie M, Long E, Washetine K, Chabannon C, Figarella-Branger D, Clément B, Mabile L, Cambon-Thomsen A, Boucher P, et al. Measuring the contribution of tumor biobanks to research in oncology: Surrogate indicators and bibliographic output. Biopreserv. Biobank. 2013; 11: 235–244. DOI: 10.1089/bio.2013.0015
Open DOI Search in Google Scholar Back to article
Clavreul A, Soulard G, Lemée J-M, Rigot M, Fabbro-Peray P, Bauchet L, Figarella-Branger D, Philippe and French Glioblastoma Biobank (FGB) network. The French glioblastoma biobank (FGB): a national clinicobiological database. Journal of Translational Medicine. 2019; 17: 133. DOI: 10.1186/s12967-019-1859-6
Open DOI Search in Google Scholar Back to article
Mariette C, Renaud F, Piessen G, et al. The FREGAT biobank: a clinic-biological database dedicated to esophageal and gastric cancers. BMC Cancer. 2018; 18(1): 139. DOI: 10.1186/s12885-018-3991-8
Open DOI Search in Google Scholar Back to article
Kandel M, Allayous C, Dalle S, Mortier L, Dalac S, Dutriaux C, Leccia MT, Guillot B, Saiag P, Lacour JP, Legoupil D, Lesimple T, Aubin F, Beylot-Barry M, Brunet-Possenti F, Arnault JP, Granel-Brocard F, Stoebner PE, Dupuy A, Maubec E, Grob JJ, et al. Update of survival and cost of metastatic melanoma with new drugs: Estimations from the MelBase cohort. European Journal of Cancer. 2018; 105: 33–40. DOI: 10.1016/j.ejca.2018.09.026
Open DOI Search in Google Scholar Back to article

The Assistance Publique Hôpitaux de Marseille’s Biobank

Abstract

Paradigm

My account