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Response to Induction Therapy in Pediatric Hodgkin’s Lymphoma: Performance of First-Order Texture Parameters of CT Images Cover

Response to Induction Therapy in Pediatric Hodgkin’s Lymphoma: Performance of First-Order Texture Parameters of CT Images

Open Access
|May 2022

Figures & Tables

jbsr-106-1-2752-g1.png
Figure 1

CT images in 17-year-old young men with Hodgkin’s lymphoma stage IIB. Illustration of nodal lesion delimitation, image filtration.

jbsr-106-1-2752-g2.png
Figure 2

CT images in 15-year-old young women with Hodgkin’s lymphoma stage IV. Illustration of the pulmonary lesion delimitation, image filtration.

Table 1

Patient characteristics.

PARAMETERALL PATIENTS (%)PATIENTS WITH AR (%)PATIENTS WITH IR (%)
TOTAL321913
Sex
      Male15 (46.9%)9 (47.4%)6 (46.2%)
      Female17 (53.1%)10 (52.6%)7 (53.8%)
Stage
      I2 (6.25%)2 (10.5%)0
      II10 (31.25%)6 (31.6%)4 (30.8%)
      III10 (31.25%)6 (31.6%)4 (30.8%)
      IV10 (31.25%)5 (26.3%)5 (38.4%)
TG
      14 (12.5%)4 (21.1%)0
      213 (40.6%)7 (36.8%)6 (46.2%)
      315 (46.9%)8 (42.1%)7 (53.8%)
Lesions
      Lymph node62 (79.5%)35 (77.8%)27 (81.8%)
      Thymus12 (15.4%)8 (17.8%)4 (12.1%)
      Lung4 (5.1%)2 (4.4%)2 (6.1%)
Table 2

Inter-reader agreement.

PARAMETER ICC (INTERVAL)SSF0SSF2SSF3SSF4SSF5SSF6
Mean0.995
(0.989–0.998)
0.791
(0.615–0.892)
0.773
(0.52–0.86)
0.837
(0.694–0.917)
0.837
(0.695–0.917)
0.849
(0.714–0.923)
Standard deviation0.884
(0.752–0.945)
0.965
(0.93–0.983)
0.974
(0.947–0.987)
0.946
(0.892–0.973)
0.923
(0.85–0.962)
0.924
(0.851–0.962)
Entropy0.96
(0.87–0.984)
0.942
(0.883–0.971)
0.896
(0.799–0.947)
0.898
(0.82–0.948)
0.889
(0.786–0.944)
0.827
(0.677–0.911)
Mean of positive pixels0.997
(0.994–0.999)
0.97
(0.939–0.985)
0.953
(0.906–0.977)
0.981
(0.789–0.945)
0.824
(0.672–0.91)
0.804
(0.639–0.899)
Skewness0.637
(0.376–0.805)
0.666
(0.42–0.821)
0.832
(0.675–0.916)
0.901
(0.801–0.951)
0.84
(0.697–0.918)
0.894
(0.794–0.947)
Kurtosis0.588
(0.31–0.774)
0.491
(0.172–0.716)
0.893
(0.795–0.946)
0.863
(0.74–0.93)
0.894
(0.794–0.947)
0.89
(0.714–0.923)

[i] The bottom ICCs (< 0,75) are in bold.

ICC = Intraclass Correlation Coefficient.

Table 3

Univariate analysis results.

PARAMETER P-VALUESSF0SSF2SSF3SSF4SSF5SSF6
Mean0.0930.340.140.300.360.33
Sd0.110.050.270.390.790.93
Entropy0.100.04*0.310.460.970.79
Mpp0.100.150.460.660.990.89
Skewness0.190.560.620.78
Kurtosis0.770.900.670.39

[i] * P < 0.05, indicating a significant difference.

DOI: https://doi.org/10.5334/jbsr.2752 | Journal eISSN: 2514-8281
Language: English
Submitted on: Jan 4, 2022
Accepted on: Apr 22, 2022
Published on: May 10, 2022
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2022 Margaux Doillon, Carole Durot, Claire Pluchart, Claude Marcus, Manel Djelouah, Aline Carsin-Vu, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.