Anticoagulation Therapy by Age and Embolic Risk for Nonvalvular Atrial Fibrillation in Mexico, an Upper-Middle-Income Country: The CARMEN-AF Registry

Manlio F. Márquez; Manuel A. Baños-González; Milton E. Guevara-Valdivia; Jorge Vázquez-Acosta; Manuel O. de los Ríos Ibarra; Julio A. Aguilar-Linares; Marcelo Jiménez-Cruz; Norberto Matadamas-Hernández; Rocío Camacho-Casillas; Reynaldo Magaña-Magaña; Ulises Rojel-Martínez; Marco A. Alcocer-Gamba; Susano Lara-Vaca; Humberto Rodríguez-Reyes; Marco A. Islava-Gálvez; Lidia E. Betancourt-Hernández; Nicolás Reyes-Reyes; Miguel E. Beltrán-Gámez; Carlos Cantú-Brito; Alberto Z. Baños-Velasco; Pedro J. del Rivero Morfin; J. Antonio González-Hermosillo

doi:10.5334/gh.767

Figures & Tables

Table 1

Geographical distribution (Mexican states) of subjects included in CARMEN-AF and other related variables.

Center	State	Level of care	Type	Specialty of the coordinator	Type of residency of the patients (Urban, rural, both)
Sociedad Cardiovascular de Aguascalientes	Aguascalientes	Third	Private	Electrophysiologist	Urban
Hospital Hidalgo	Aguascalientes	Third	Public	Cardiologist	Both
Hospital Regional No1 IMSS, Tijuana	Baja California	Second	Public	Cardiologist	Both
Hospital Angeles Tijuana	Baja California	Third	Private	Cardiologist/Internist	Urban
Plaza Medical	Baja California	Third	Private	Cardiologist	Urban
Hospital General ISSSTE, La Paz	Baja California sur	Third	Public	Cardiologist/Internist	Urban
Hospital GE ‘Dr Javier Buenfil Osorio’ INDESALUD	Campeche	Third	Public	Cardiologist	Both
Instituto Nacional de Cardiologist ‘Ignacio Chavez’	Mexico City	Third	Public	Electrophysiologist	Both
Hospital de Especialidades, Centro Medico Nacional ‘La Raza’ IMSS	Mexico City	Third	Public	Electrophysiologist	Both
Hospital de Cardiologist del Centro Medico Nacional ‘Siglo XXI’ IMSS	Mexico City	Third	Public	Electrophysiologist	Both
Hospital General de Mexico	Mexico City	Third	Public	Electrophysiologist	Urban
Instituto Nacional de Ciencias Medicas y Nutricion ‘Salvador Zubiran’	Mexico City	Third	Public	Neurologist	Urban
CIMA Chihuahua	Chihuahua	Third	Private	Cardiologist	Urban
Unidad Medica de Alta Especialidad No71 IMSS, Coahuila	Coahuila	Third	Public	Cardiologist	Urban
Hospital General de Zona No 10, Manzanillo	Colima	Second	Public	Cardiologist/Internist	Urban
Hospital General de Zona No 1 IMSS, Durango	Durango	Second	Public	Cardiologist/Internist	Both
ISSEMYM Toluca	Estado de Mexico	Third	Public	Electrophysiologist	Urban
Hospital Angeles Leon	Guanajuato	Third	Private	Electrophysiologist	Both
Hospital General de Acapulco	Guerrero	Third	Public	Cardiologist/Internist	Both
Hospital General de Pachuca	Hidalgo	Third	Public	Cardiologist/Internist	Both
Hospital Civil de Guadalajara	Jalisco	Third	Public	Cardiologist/Internist	Urban
Hospital General de Uruapan	Michoacan	Second	Public	Cardiologist	Both
Instituto Nacional de Trasplantes	Morelos	Second	Private	Cardiologist/Internist	Urban
Instituto de Cardiologist y Medicina Vascular Hospital Zambrano, Tec Salud	Nuevo Leon	Third	Private	Electrophysiologist	Urban
Hospital Regional de Alta Especialidad de Oaxaca	Oaxaca	Third	Public	Cardiologist. Internist	Urban
Clinica Molina	Oaxaca	Segunda	Public	Cardiologist	Urban
Hospital General del Sur de Puebla	Puebla	Third	Private	Electrophysiologist	Urban
Hospital Angeles de Puebla	Puebla	Third	Private	Electrophysiologist	Urban
Instituto del Corazon Queretaro	Queretaro	Third	Private	Internist	Both
Hospital General de Zona No3 IMSS	Quintana Roo	Second	Public	Cardiologist	Both
Hospital Central ‘Dr Ignacio Morones Prieto’	San Luis Potosi	Third	Public	Cardiologist	Both
Torre Medica Olivos	San Luis Potosi	Primer	Private	Cardiologist	Urban
Hospital Civil de Culiacan	Sinaloa		Public	Cardiologist	Both
Angeles Culiacan	Sinaloa	Third	Private	Cardiologist/Internist	Urban
Hospital General de Culiacan	Sinaloa	Second	Public	Cardiologist/Internist	Both
Centro Medico Nacional del Noroeste IMSS	Sonora	Third	Public	Cardiologist	Both
Hospital Regional de Alta Especialidad ‘Juan Graham Casasus’	Tabasco	Third	Public	Cardiologist/Internist	Both
Hospital Regional de PEMEX Ciudad Madero	Tamaulipas	Third	Public	Cardiologist	Both
Unidad Medica de Alta Especialidad No 14 IMSS	Veracruz	Third	Public	Cardiologist	Both
Star Medica Merida	Yucatan	Third	Private	Cardiologist	Urban
Hospital ‘San Agustin’	Zacatecas	Third	Private	Cardiologist	Both

Table 2

Demographic characteristics.

Demographic characteristics
	All(n = 1,423)	Male(n = 731)	Female(n = 692)	P*
Gender (%)		51.4	48.6	ns
Age, years ± SD	69 ± 13	68 ± 13	70 ± 12	=0.002
Weight, kg ± SD	75 ± 16	80 ± 15	69 ± 14	<0.0001
Body Mass Index, kg/m² ± SD	28.5 ± 5.0	28.4 ± 4.6	28.7 ± 5.4	ns

[i] * P value was obtained comparing Gender groups using Chi-square test and Student’s t-test.

Table 3

Comorbidities of total population.

Comorbidities
(%)	All (n = 1,423)	Male (n = 731)	Female (n = 692)	P*
Hypertension	72.5	71.3	73.8	ns
Diabetes	28.4	31.3	25.3	=0.007
Heart failure	23.6	25.3	21.8	ns
Smoking	16.4	23.9	8.5	<0.0001
Alcoholism	9.2	17.1	0.9	<0.0001
Nonischemic cardiomyopathy**	8.9	10.3	7.5	=0.042
Coronary Artery Disease	7.1	9.7	4.3	<0.0001
Obstructive sleep apnea	3.9	5.2	2.6	=0.008
Peripheral artery disease	1.8	1.0	2.7	=0.010

[i] * P value was obtained comparing Gender groups using Chi-square test and Student’s t-test.

** Hipertensive, Idiopathic, and restrictive.

Table 4

Antithrombotic therapy according to AF type.

Antithrombotic therapy according to AF type
(%) P = 0.037*	All (n = 1,423)	Paroxysmal (n = 531)	Persistent (n = 314)	Permanent (n = 578)
Without treatment	16.6	17.5	15.9	16.1
Antiplatelet	19.4	22.4	19.7	16.4
Anticoagulant	56.8	53.7	54.1	61.1
Anticoagulant + Antiplatelet	5.7	4.9	8.9	4.7
Triple therapy	1.5	1.5	1.3	1.7

[i] * P value was obtained comparing Gender groups using Chi-square test and Student’s t-test.

Antithrombotic therapy by AF type (%).
* P value was obtained comparing AF type groups vs Treatment groups using Chi-square test.

Antithrombotic therapy according to CHA₂DS₂-VASc risk (%).
* P value was obtained comparing Treatment groups vs CHA₂DS₂-VASc groups using Chi-square test.

Antithrombotic therapy according to age (%).
* P value was obtained comparing Treatment groups vs Age groups using Chi-square test.

Anticoagulation Therapy by Age and Embolic Risk for Nonvalvular Atrial Fibrillation in Mexico, an Upper-Middle-Income Country: The CARMEN-AF Registry

Figures & Tables

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