Table 1
Summary of the evidence on the effect of periodontal therapy on surrogate markers of cardiovascular diseases.
| Topic | Outcome | Number of RCTs and SR since last consensus | References | Effect | Overall Level of Evidence |
|---|---|---|---|---|---|
| Effect of Periodontal Therapy on Lipids | Lipids (multiple) | 6 RCTs | [12, 22, 26, 38, 44, 51] | No | Moderate |
| Effect of Periodontal Therapy on Blood Pressure | Systolic, diastolic | 3 RCTs | [22, 44, 142] | Yes | Limited |
| Effect of Periodontal Therapy on Endothelial Function | Endothelial Function (multiple measures) | 2 RCTs | [22, 105] | Yes | Moderate |
| 1 SR | [122] | ||||
| Effect of Periodontal Therapy on interleukin (IL)-6 | IL-6 | 3 RCTs | [38, 51, 142] | Yes | Moderate |
| Effect of Periodontal Therapy on C-Reactive Protein (CRP) | CRP | 5 SR | [27, 37, 49, 90, 125] | Yes | Moderate |
| 7 RCTs following 2014 | [12, 22, 26, 44, 51, 53, 142] | ||||
| Effect of Periodontal Therapy on Pulse Wave Velocity (PWV) | PWV | 1 RCT | [51] | No | Limited |
| Effect of Periodontal Therapy on carotid Intima-Media Thickness (c-IMT) | Common c-IMT | 1 RCT | [51] | Yes | Limited |
[i] RCT, randomised clinical trial; SR, systematic review.