Have a personal or library account? Click to login
Prognostic Value of In-Hospital Nutritional Status Improvement in Heart Failure: Insights From JROADHF-NEXT Registry Cover

Prognostic Value of In-Hospital Nutritional Status Improvement in Heart Failure: Insights From JROADHF-NEXT Registry

Global Heart
Volume 21 (2026): Issue 1
By: Toshitaka Okabe,  Keisuke Kida,  Nobuyuki Enzan,  Masataka Ikeda,  Takahiro Okumura,  Takeshi Kitai,  Takeshi Tohyama,  Tatsunori Taniguchi,  Shouji Matsushima,  Yuya Matsue and  Hiroyuki Tsutsui  
Open Access
|Mar 2026

References

  1. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, et al. ESC Scientific Document Group. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599–3726. DOI: 10.1093/eurheartj/ehab368 [Erratum in: Eur Heart J. 2021;42(48):4901. DOI: https://doi.org/10.1093/eurheartj/ehab670]
    Open DOISearch in Google ScholarBack to article
  2. Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, et al. AHA/ACC/HFSA Guideline for the management of heart failure: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2022;79(17):e263–e421. DOI: 10.1016/j.jacc.2021.12.012 [Erratum in: J Am Coll Cardiol. 2023;81(15):1551. DOI: https://doi.org/10.1016/j.jacc.2023.03.002]
    Open DOISearch in Google ScholarBack to article
  3. Kitai T, Kohsaka S, Kato T, Kato E, Sato K, Teramoto K, et al. Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group. JCS/JHFS 2025 Guideline on Diagnosis and Treatment of Heart Failure. Circ J. 2025;89(8):1278–1444. DOI: 10.1253/circj.CJ-25-0002
    Open DOISearch in Google ScholarBack to article
  4. Sze S, Pellicori P, Zhang J, Clark AL. Malnutrition, congestion and mortality in ambulatory patients with heart failure. Heart. 2019;105:297–306. DOI: 10.1136/heartjnl-2018-313312
    Open DOISearch in Google ScholarBack to article
  5. Uchida S, Kamiya K, Yamashita M, Noda T, Kagiyama N, Matsue Y. Current findings and challenges on frailty, sarcopenia, and cachexia in older patients with heart failure: insights from the FRAGILE-HF study. J Cardiol. 2026;87:10–16. DOI: 10.1016/j.jjcc.2025.05.013
    Open DOISearch in Google ScholarBack to article
  6. Agnoletti D, Arcaro G, Scaturro G, Turcato E, Grison E, Ferrari E, Bonapace S, Targher G, Valbusa F. Controlling nutritional status score predicts 2-year outcomes in elderly patients admitted for acute heart failure. Intern Emerg Med. 2023;18(4):1031–1039. DOI: 10.1007/s11739-023-03230-x
    Open DOISearch in Google ScholarBack to article
  7. Ignacio de Ulíbarri J, González-Madroño A, de Villar NG, González P, González B, Mancha A, Rodríguez F, Fernández G. CONUT: A tool for controlling nutritional status. First validation in a hospital population. Nutr Hosp. 2005;20:38–45.
    Search in Google ScholarBack to article
  8. Li L, Shou L. Prognostic and clinicopathological significance of the Controlling Nutritional Status (CONUT) score in patients with lymphoma: A meta-analysis. BMJ Open. 2024;14(3):e078320. DOI: 10.1136/bmjopen-2023-078320
    Open DOISearch in Google ScholarBack to article
  9. Chen J, Song P, Peng Z, Liu Z, Yang L, Wang L, Zhou J, Dong Q. The Controlling Nutritional Status (CONUT) score and prognosis in malignant tumors: A systematic review and meta-analysis. Nutr Cancer. 2022;74(9):3146–3163. DOI: 10.1080/01635581.2022.2059091
    Open DOISearch in Google ScholarBack to article
  10. Fărcaș DA, Cerghizan A, Maior R, Mîndrilă AC, Tarcea M. CONUT score as a predictor of mortality risk in acute and chronic heart failure: A meta-analytic review. Nutrients. 2025;17(10):1736. DOI: 10.3390/nu17101736
    Open DOISearch in Google ScholarBack to article
  11. Enzan N, Tohyama T, Watanabe T, Nagata T, Noda E, Tsutsui Y, et al. Clinical characteristics and outcomes of hospitalized patients with heart failure from the Japanese prospective registry. J Cardiol. 2026;87:85–91. DOI: 10.1016/j.jjcc.2025.05.015
    Open DOISearch in Google ScholarBack to article
  12. JCS Joint Working Group. Guidelines for treatment of acute heart failure (JCS 2011). Circ J. 2013;77:2157–201. DOI: 10.1253/circj.CJ-66-0068
    Open DOISearch in Google ScholarBack to article
  13. Okabe T, Yakushiji T, Kato D, Sato H, Matsuda T, Koyanagi Y, et al. Impact of Bicytopenia on mortality in hospitalised patients with heart failure. Glob Heart. 2025;20(1):41. DOI: 10.5334/gh.1425
    Open DOISearch in Google ScholarBack to article
  14. Anand IS, Claggett B, Liu J, Shah AM, Rector TS, Shah SJ, et al. Interaction between spironolactone and natriuretic peptides in patients with heart failure and preserved ejection fraction: From the TOPCAT trial. JACC Heart Fail. 2017;5(4):241–252. DOI: 10.1016/j.jchf.2016.11.015
    Open DOISearch in Google ScholarBack to article
  15. Hendricks S, Dykun I, Balcer B, Totzeck M, Rassaf T, Mahabadi AA. Higher BNP/NT-pro BNP levels stratify prognosis equally well in patients with and without heart failure: A meta-analysis. ESC Heart Fail. 2022;9(5):3198–3209. DOI: 10.1002/ehf2.14019
    Open DOISearch in Google ScholarBack to article
  16. Scotti A, Coisne A, Granada JF, Driggin E, Madhavan MV, Zhou Z, et al. Impact of malnutrition in patients with heart failure and secondary mitral regurgitation: The COAPT trial. J Am Coll Cardiol. 2023;82(2):128–138. DOI: 10.1016/j.jacc.2023.04.047
    Open DOISearch in Google ScholarBack to article
  17. Prokopidis K, Chen Y, Liu Y, Zhong Z, Morwani-Mangnani J, Cuthbertson DJ, Sankaranarayanan R, Lip GYH, Isanejad M. Assessing the link of malnutrition with diabetes and mortality risk in heart failure patients. ESC Heart Fail. 2025;12(4):3103–3113. DOI: 10.1002/ehf2.15263
    Open DOISearch in Google ScholarBack to article
  18. Xu D, Shen R, Hu M, Fan Q, Wu J. Prognostic impact of CONUT score in older patients with chronic heart failure. BMC Geriatr. 2024;24(1):738. DOI: 10.1186/s12877-024-05330-5
    Open DOISearch in Google ScholarBack to article
  19. Takada T, Jujo K, Inagaki K, Abe T, Kishihara M, Shirotani S, Endo N, Watanabe S, Suzuki K, Minami Y. Nutritional status during hospitalization is associated with the long-term prognosis of patients with heart failure. ESC Heart Fail. 2021;8(6):5372–5382. DOI: 10.1002/ehf2.13629
    Open DOISearch in Google ScholarBack to article
  20. Pasini E, Aquilani R, Testa C, Baiardi P, Angioletti S, Boschi F, Verri M, Dioguardi F. Pathogenic gut flora in patients with chronic heart failure. JACC Heart Fail. 2016;4(3):220–227. DOI: 10.1016/j.jchf.2015.10.009
    Open DOISearch in Google ScholarBack to article
  21. Matacchione G, Piacenza F, Pimpini L, Rosati Y, Marcozzi S. The role of the gut microbiota in the onset and progression of heart failure: insights into epigenetic mechanisms and aging. Clin Epigenetics. 2024;16(1):175. DOI: 10.1186/s13148-024-01786-9
    Open DOISearch in Google ScholarBack to article
  22. Soto ME, Pérez-Torres I, Rubio-Ruiz ME, Manzano-Pech L, Guarner-Lans V. Interconnection between cardiac cachexia and heart failure-protective role of cardiac obesity. Cells. 2022;11(6):1039. DOI: 10.3390/cells11061039
    Open DOISearch in Google ScholarBack to article
  23. Afsar B, Afsar RE, Caliskan Y, Lentine KL, Edwards JC. Renin angiotensin system-induced muscle wasting: putative mechanisms and implications for clinicians. Mol Cell Biochem. 2025;480(4):1935–1949. DOI: 10.1007/s11010-024-05043-8
    Open DOISearch in Google ScholarBack to article
  24. Arques S, Ambrosi P. Human serum albumin in the clinical syndrome of heart failure. J Card Fail. 2011;17(6):451–458. DOI: 10.1016/j.cardfail.2011.02.010
    Open DOISearch in Google ScholarBack to article
  25. Joaquín C, Alonso N, Lupón J, de Antonio M, Domingo M, Moliner P, et al. Mini nutritional assessment short form is a morbi-mortality predictor in outpatients with heart failure and mid-range left ventricular ejection fraction. Clin Nutr. 2020;39(11):3395–3401. DOI: 10.1016/j.clnu.2020.02.031
    Open DOISearch in Google ScholarBack to article
  26. Sawczak F, Soloch A, Cierzniak M, Szubarga A, Kurkiewicz-Sawczak K, Kukfisz A, et al. Loop diuretic dose and nutritional status of patients with heart failure with reduced ejection fraction. Nutrients. 2025;17(13):2105. DOI: 10.3390/nu17132105
    Open DOISearch in Google ScholarBack to article
  27. Graterol Torres F, Molina M, Soler-Majoral J, Romero-González G, Rodríguez Chitiva N, Troya-Saborido M, et al. Evolving concepts on inflammatory biomarkers and malnutrition in chronic kidney disease. Nutrients. 2022;14(20):4297. DOI: 10.3390/nu14204297
    Open DOISearch in Google ScholarBack to article
  28. Hersberger L, Dietz A, Bürgler H, Bargetzi A, Bargetzi L, Kägi-Braun N, et al. Individualized nutritional supportfor hospitalized patients with chronic heart failure. J Am Coll Cardiol. 2021;77:2307–2319. DOI: 10.1016/j.jacc.2021.03.232
    Open DOISearch in Google ScholarBack to article
DOI: https://doi.org/10.5334/gh.1534 | Journal eISSN: 2211-8179
Journal RSS Feed
Language: English
Submitted on: Dec 2, 2025
|
Accepted on: Feb 23, 2026
|
Published on: Mar 13, 2026
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
heart failure,
malnutrition,
nutritional status,
CONUT score,
prognosis

© 2026 Toshitaka Okabe, Keisuke Kida, Nobuyuki Enzan, Masataka Ikeda, Takahiro Okumura, Takeshi Kitai, Takeshi Tohyama, Tatsunori Taniguchi, Shouji Matsushima, Yuya Matsue, Hiroyuki Tsutsui, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.

Previous articleVolume 21 (2026): Issue 1Next article