References
- Ribeiro ALP, Collaborators RS, Machado I, Cousin E, Perel P, Demacq C, et al. The burden of chagas disease in the contemporary world: The RAISE study. Global Heart. 2024;19(1):2. DOI: 10.5334/gh.1280
- Echeverria LE, Marcus R, Novick G, Sosa-Estani S, Ralston K, Zaidel EJ, et al. WHF IASC Roadmap on Chagas Disease. Global Heart. 2020;15(1):26. DOI: 10.5334/gh.484
- Nunes MCP, Beaton A, Acquatella H, Bern C, Bolger AF, Echeverria LE, et al. Chagas cardiomyopathy: An update of current clinical knowledge and management: A scientific statement from the American Heart Association. Circulation. 2018;138(12):e169–e209. DOI: 10.1161/CIR.0000000000000599
- Sabino EC, Nunes MCP, Blum J, Molina I, Ribeiro ALP. Cardiac involvement in Chagas disease and African trypanosomiasis. Nature Reviews Cardiology. 2024;21(12):865–879. DOI: 10.1038/s41569-024-01057-3
- First WHO report on neglected tropical diseases: Working to overcome the global impact of neglected tropical diseases. World Health Organization. Accessed Oct 2023. Available from:
https://iris.who.int/bitstream/handle/10665/44440/9789241564090_eng.pdf?sequence=1 . - Klein K, Burrone MS, Alonso JP, Ares LR, Marti SG, Lavenia A, et al. [Strategy to improve access to etiological treatment of Chagas disease at the first level of care in Argentina]. Revista Panamericana de Salud Pública. 2017;41:
e20 . - Perez-Molina JA, Molina I. Chagas disease. Lancet. 2018;391(10115):82–94. DOI: 10.1016/S0140-6736(17)31612-4
- Donabedian A. The quality of care. How can it be assessed? JAMA. 1988;260(12):1743–1748. DOI: 10.1001/jama.260.12.1743
- Donabedian A. Evaluating the quality of medical care. 1966. The Milbank Quarterly. 2005;83(4):691–729. DOI: 10.1111/j.1468-0009.2005.00397.x
- Santry HP, Strassels SA, Ingraham AM, Oslock WM, Ricci KB, Paredes AZ, et al. Identifying the fundamental structures and processes of care contributing to emergency general surgery quality using a mixed-methods Donabedian approach. BMC Medical Research Methodology. 2020;20(1):247. DOI: 10.1186/s12874-020-01096-7
- Marin-Neto JA, Rassi A
Jr. , Oliveira GMM, Correia LCL, Ramos Junior AN, Luquetti AO, et al. SBC guideline on the diagnosis and treatment of patients with cardiomyopathy of chagas disease – 2023. Arquivos Brasileiros de Cardiologia. 2023;120(6):e20230269 . DOI: 10.36660/abc.20230269 - World Health Organization.
Integrating health services: brief [Internet] . World Health Organization; 2018 [cited 2025 Jan 28]. Report No.: WHO/HIS/SDS/2018.50. Available from:https://iris.who.int/handle/10665/326459 . - Behera B, Prasad R, Shyambhavee.
Primary health-care goal and principles . In Behera B, Prasad R, & Shyambhavee (Eds.) Healthcare strategies and planning for social inclusion and development. Elsevier, Amsterdam: Elsevier; 2022. pp. 221–239. DOI: 10.1016/B978-0-323-90446-9.00008-3 - GBD 2023 Chagas Disease and RAISE Study Collaborators. Global, Regional, and National Burden of Chagas Disease, 1990–2023: A Systematic Analysis for the Global Burden of Disease Study 2023 (June 18, 2025). DOI: 10.2139/ssrn.5381800
- Actualización de la estimación de la enfermedad de Chagas en los países endémicos de las Américas 2018. Pan American Health Organization (PAHO). Available from:
https://iris.paho.org/bitstream/handle/10665.2/67559/OPSCDEVT250005_spa.pdf?sequence=1&isAllowed=y . - Wheelock A, Sandhu S, Reifler K, Carrion M, Bourque DL, Hamer DH, et al. Improving clinician awareness of and screening for chagas disease with an educational intervention. American Journal of Tropical Medicine and Hygiene. 2024;111(2):380–386. DOI: 10.4269/ajtmh.23-0483
- Hochberg NS, Montgomery SP. Chagas disease. Annals of Internal Medicine. 2023;176(2):ITC17–ITC32. DOI: 10.7326/AITC202302210
- Rassi A
Jr. , Grimshaw A, Sarwal A, Sah R, Shah S, Agudelo Higuita NI, et al. Impact of antiparasitic therapy on cardiovascular outcomes in chronic Chagas disease. A systematic review and meta-analysis. EClinicalMedicine. 2025;79:102972. DOI: 10.1016/j.eclinm.2024.102972 - Paixao LC, Ribeiro AL, Valacio RA, Teixeira AL. Chagas disease: Independent risk factor for stroke. Stroke. 2009;40(12):3691–3694. DOI: 10.1161/STROKEAHA.109.560854
- Morillo CA, Marin-Neto JA, Avezum A, Sosa-Estani S, Rassi A
Jr. , Rosas F, et al. Randomized trial of benznidazole for chronic chagas’ cardiomyopathy. New England Journal of Medicine. 2015;373(14):1295–1306. DOI: 10.1056/NEJMoa1507574 - Bocchi EA, Fiorelli A. The paradox of survival results after heart transplantation for cardiomyopathy caused by Trypanosoma cruzi. First Guidelines Group for Heart Transplantation of the Brazilian Society of Cardiology. Annals of Thoracic Surgery. 2001;71(6):1833–1838. DOI: 10.1016/S0003-4975(01)02587-5
- Ralston K, Zaidel E, Acquatella H, Barbosa MM, Narula J, Nakagama Y, et al. WHF recommendations for the use of echocardiography in chagas disease. Global Heart. 2023;18(1):27. DOI: 10.5334/gh.1207
- Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, et al. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145(18):e895–e1032. DOI: 10.1161/CIR.0000000000001063
- First WHO report on neglected tropical diseases: working to overcome the global impact of neglected tropical diseases. World Health Organization. 2010. Available from:
https://iris.who.int/bitstream/handle/10665/44440/9789241564090_eng.pdf?sequence=1 . - Lidani KCF, Andrade FA, Bavia L, Damasceno FS, Beltrame MH, Messias-Reason IJ, et al. Chagas disease: From discovery to a worldwide health problem. Frontiers in Public Health. 2019;7:166. DOI: 10.3389/fpubh.2019.00166
- Hayon J, Lupo S, Poveda C, Jones KM, Qian Q, Wu H, et al. Adaptation of chagas disease screening recommendations for a community of at-risk HIV in the United States. Clinical Infectious Diseases. 2024;78(2):453–456. DOI: 10.1093/cid/ciad616
- Lopes EL, Beaton AZ, Nascimento BR, Tompsett A, Dos Santos JP, Perlman L, et al. Telehealth solutions to enable global collaboration in rheumatic heart disease screening. Journal of Telemedicine and Telecare. 2018;24(2):101–109. DOI: 10.1177/1357633X16677902
- Beaton A, Nascimento BR, Diamantino AC, Pereira GT, Lopes EL, Miri CO, et al. Efficacy of a standardized computer-based training curriculum to teach echocardiographic identification of rheumatic heart disease to nonexpert users. American Journal of Cardiology. 2016;117(11):1783–1789. DOI: 10.1016/j.amjcard.2016.03.006
- Nascimento BR, Beaton AZ, Nunes MCP, Tompsett AR, Oliveira KKB, Diamantino AC, et al. Integration of echocardiographic screening by non-physicians with remote reading in primary care. Heart. 2019;105(4):283–290. DOI: 10.1136/heartjnl-2018-313593
- Diamantino AC, Nascimento BR, Nunes MCP, Sable CA, Oliveira KKB, Rabelo LC, et al. Impact of incorporating echocardiographic screening into a clinical prediction model to optimise utilisation of echocardiography in primary care. International Journal of Clinical Practice. 2021;75(3):
e13686 . DOI: 10.1111/ijcp.13686 - Fraga LL, Nascimento BR, Haiashi BC, Ferreira AM, Silva MHA, Ribeiro I, et al. Combination of tele-cardiology tools for cardiovascular risk stratification in primary care: Data from the PROVAR+ study. Arquivos Brasileiros de Cardiologia. 2024;121(2):
e20230653 . DOI: 10.36660/abc.20230653 - Jidling C, Gedon D, Schon TB, Oliveira CDL, Cardoso CS, Ferreira AM, et al. Screening for Chagas disease from the electrocardiogram using a deep neural network. PLOS Neglected Tropical Diseases. 2023;17(7):
e0011118 . DOI: 10.1371/journal.pntd.0011118 - Fonseca IM, Nunes MCP, Nascimento BR, Mendoza R, Carmo A, Nogueira G, et al. Utilizing AI-driven ECG analysis for early chagas disease diagnosis: Insights from a cross-sectional study in Brazil. JACC. 2025;85(12_Supplement):2837. DOI: 10.1016/S0735-1097(25)03321-2
- Brito BOF, Attia ZI, Martins LNA, Perel P, Nunes MCP, Sabino EC, et al. Left ventricular systolic dysfunction predicted by artificial intelligence using the electrocardiogram in Chagas disease patients-The SaMi-Trop cohort. PLOS Neglected Tropical Diseases. 2021;15(12):
e0009974 . DOI: 10.1371/journal.pntd.0009974 - Seidman G, Atun R. Does task shifting yield cost savings and improve efficiency for health systems? A systematic review of evidence from low-income and middle-income countries. Human Resources for Health. 2017;15(1):29. DOI: 10.1186/s12960-017-0200-9
- Ubels J, Sable C, Beaton AZ, Nunes MCP, Oliveira KKB, Rabelo LC, et al. Cost-effectiveness of rheumatic heart disease echocardiographic screening in Brazil: Data from the PROVAR+ study: Cost-effectiveness of RHD screening in Brazil. Global Heart. 2020;15(1):18. DOI: 10.5334/gh.529
- Oliveira CRA, Paixao GMM, Tostes VC, Gomes PR, Mendes MS, Paixao MC, et al. Upscaling a regional telecardiology service to a nationwide coverage and beyond: the experience of the Telehealth Network of Minas Gerais. BMJ Glob Health. 2025;10(1):
e016692 . DOI: 10.1136/bmjgh-2024-016692 - Cormick G, Ciganda A, Cafferata ML, Ripple MJ, Sosa-Estani S, Buekens P, et al. Text message interventions for follow up of infants born to mothers positive for Chagas disease in Tucuman, Argentina: A feasibility study. BMC Research Notes. 2015;8:508. DOI: 10.1186/s13104-015-1498-9
- da Rocha Siriano L, Marchiol A, Pereira Certo M, Cubides JC, Forsyth C, Augusto de Sousa F. Mandatory notification of chronic chagas disease: Confronting the epidemiological silence in the state of Goias, Brazil. Tropical Medicine and Infectious Disease. 2020;5(2):92. DOI: 10.3390/tropicalmed5020092
- de Arias AR, Monroy C, Guhl F, Sosa-Estani S, Santos WS, Abad-Franch F. Chagas disease control-surveillance in the Americas: The multinational initiatives and the practical impossibility of interrupting vector-borne Trypanosoma cruzi transmission. Memórias do Instituto Oswaldo Cruz. 2022;117:
e210130 . DOI: 10.1590/0074-02760210130 - Sangenito LS, Branquinha MH, Santos ALS. Funding for chagas disease: A 10-year (2009–2018) survey. Tropical Medicine and Infectious Disease. 2020;5(2):88. DOI: 10.3390/tropicalmed5020088
- No research about us without us: why research capacity strengthening is essential to health for all. World Health Organization. 2021. Available from:
https://www.who.int/news/item/16-11-2021-no-research-about-us-without-us-why-research-capacity-strengthening-is-essential-to-health-for-all .