
Following the Pandemic: Exploring Long COVID’s impact on Global Health through the World Heart Federation Global COVID-19 Study
By: Karla Santo, Leandro Favaro and Eduardo Martins
References
- Crook H, Raza S, Nowell J, Young M, Edison P. Long covid-mechanisms, risk factors, and management. BMJ. 2021;374:n1648. DOI: 10.1136/bmj.n1648
- Davis HE, McCorkell L, Vogel JM, Topol EJ. Long COVID: Major findings, mechanisms and recommendations. Nat Rev Microbiol. 2023;21(3):133–146. DOI: 10.1038/s41579-022-00846-2
- Ely EW, Brown LS, Fineberg HV. Long COVID defined. NEJM. 2024;391(18):1746–1753. DOI: 10.1056/nejmSB2408466
- Greenhalgh T, Sivan M, Perlowski A, Nikolich JZ. Long COVID: A clinical update. Lancet. 2024;404(10453):707–724. DOI: 10.1016/S0140-6736(24)01136-X
- Prabhakaran D, Singh K, Kondal D, Raspail L, Mohan B, Kato T, et al. Cardiovascular risk factors and clinical outcomes among patients hospitalized with COVID-19: Findings from the World Heart Federation COVID-19 Study. Glob Heart. 2022;17(1):40. DOI: 10.5334/gh.1128
- Sliwa K, Singh K, Nikhare K, Kondal D, Raspail L, Jain M, et al. Long COVID syndrome, mortality and morbidity in patients hospitalized with COVID-19 from 16 countries: The World Heart Federation Global COVID-19 study. Glob Heart. 2025;20(1):66. DOI: 10.5334/gh.1452
- Hyams C, Challen R, Marlow R, Nguyen J, Begier E, Southern J, et al. Severity of Omicron (B.1.1.529) and Delta (B.1.617.2) SARS-CoV-2 infection among hospitalised adults: A prospective cohort study in Bristol, United Kingdom. Lancet Reg Health Eur. 2023;25:100556. DOI: 10.1016/j.lanepe.2022.100556
- Karuniawati A, Pasaribu AP, Lazarus G, Irawany V, Nusantara DU, Sinto R, et al. Characteristics and clinical outcomes of patients with pre-delta, delta and omicron SARS-CoV-2 infection in Indonesia (2020–2023): A multicentre prospective cohort study. Lancet Reg Health Southeast Asia. 2024;22:100348. DOI: 10.1016/j.lansea.2023.100348
- Al-Aly Z, Xie Y, Bowe B. High-dimensional characterization of post-acute sequelae of COVID-19. Nature. 2021;594(7862):259–264. DOI: 10.1038/s41586-021-03553-9
- Bowe B, Xie Y, Al-Aly Z. Postacute sequelae of COVID-19 at 2 years. Nat Med. 2023;29(9):2347–2357. DOI: 10.1038/s41591-023-02521-2
- Vardavas C, Zisis K, Nikitara K, Lagou I, Marou V, Aslanoglou K, et al. Cost of the COVID-19 pandemic versus the cost-effectiveness of mitigation strategies in EU/UK/OECD: A systematic review. BMJ Open. 2023;13(10):
e077602 . DOI: 10.1136/bmjopen-2023-077602 - Byambasuren O, Stehlik P, Clark J, Alcorn K, Glasziou P. Effect of covid-19 vaccination on long covid: Systematic review. BMJ Med. 2023;2(1):
e000385 . DOI: 10.1136/bmjmed-2022-000385 - Lam ICH, Zhang R, Man KKC, Wong CKH, Chui CSL, Lai FTT, et al. Persistence in risk and effect of COVID-19 vaccination on long-term health consequences after SARS-CoV-2 infection. Nat Commun. 2024;15(1):1716. DOI: 10.1038/s41467-024-45953-1
- urname>Gao Y, Cai C, Adamo S, Biteus E, Kamal H, Dager L, et al. Identification of soluble biomarkers that associate with distinct manifestations of long COVID. Nat Immunol. 2025;26(5):692–705. DOI: 10.1038/s41590-025-02135-5
- Rahmati M, Udeh R, Kang J, Dolja-Gore X, McEvoy M, Kazemi A, et al. Long-term sequelae of COVID-19: A systematic review and meta-analysis of symptoms 3 years post-SARS-CoV-2 infection. J Med Virol. 2025;97(6):
e70429 . DOI: 10.1002/jmv.70429
DOI: https://doi.org/10.5334/gh.1468 | Journal eISSN: 2211-8179
Language: English
Submitted on: Aug 25, 2025
Accepted on: Aug 27, 2025
Published on: Sep 12, 2025
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
© 2025 Karla Santo, Leandro Favaro, Eduardo Martins, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.