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Association Between High Sensitivity Cardiac Troponin and All-Cause and Cardiovascular Mortality in Adults at Risk of Non-Alcoholic Fatty Liver Disease: A Cohort Study Cover

Association Between High Sensitivity Cardiac Troponin and All-Cause and Cardiovascular Mortality in Adults at Risk of Non-Alcoholic Fatty Liver Disease: A Cohort Study

Open Access
|Apr 2025

References

  1. 1Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology (Baltimore, Md). 2016;64(1):7384. DOI: 10.1097/HEP.0000000000000004
  2. 2Cotter TG, Rinella M. Nonalcoholic Fatty Liver Disease 2020: The State of the Disease. Gastroenterology. 2020;158(7):18511864. DOI: 10.1053/j.gastro.2020.01.052
  3. 3Buzzetti E, Pinzani M, Tsochatzis EA. The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metab. Clin Exp. 2016;65(8):10381048. DOI: 10.1016/j.metabol.2015.12.012
  4. 4Targher G, Byrne CD, Lonardo A, Zoppini G, Barbui C. Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis. J Hepatol. 2016;65(3):589600. DOI: 10.1016/j.jhep.2016.05.013
  5. 5Aakre KM, Saenger AK, Body R, et al. Analytical Considerations in Deriving 99th Percentile Upper Reference Limits for High-Sensitivity Cardiac Troponin Assays: Educational Recommendations from the IFCC Committee on Clinical Application of Cardiac Bio-Markers. Clin. Chem. 2022;68(8):10221030. DOI: 10.1093/clinchem/hvac092
  6. 6McEvoy JW, Tang O, Wang D, et al. Myocardial Injury Thresholds for 4 High-Sensitivity Troponin Assays in U.S. Adults. J. Am Coll Cardiol. 2023;81(20):20282039. DOI: 10.1016/j.jacc.2023.03.403
  7. 7Jia X, Sun W, Hoogeveen RC, et al. High-Sensitivity Troponin I and Incident Coronary Events, Stroke, Heart Failure Hospitalization, and Mortality in the ARIC Study. Circulation. 2019;139(23):26422653. DOI: 10.1161/circulationaha.118.038772
  8. 8McEvoy JW, Daya N, Tang O, et al. High-sensitivity troponins and mortality in the general population. Eur. Heart J. 2023;44(28):25952605. DOI: 10.1093/eurheartj/ehad328
  9. 9McEvoy JW, Wang D, Tang O, et al. Four high sensitivity troponin assays and mortality in US adults with cardiovascular disease: The national health and nutrition examination survey, 1999–2004. Am. J. Prev Cardiol. 2024;17:100631. DOI: 10.1016/j.ajpc.2023.100631
  10. 10Scheven L, de Jong PE, Hillege HL, et al. High-sensitive troponin T and N-terminal pro-B type natriuretic peptide are associated with cardiovascular events despite the cross-sectional association with albuminuria and glomerular filtration rate. Eur. Heart J. 2012;33(18):22722281. DOI: 10.1093/eurheartj/ehs163
  11. 11Cavender MA, White WB, Jarolim P, et al. Serial Measurement of High-Sensitivity Troponin I and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus in the EXAMINE Trial (Examination of Cardiovascular Outcomes With Alogliptin Versus Standard of Care). Circulation. 2017;135(20):19111921. DOI: 10.1161/circulationaha.116.024632
  12. 12Mantovani A, Csermely A, Petracca G, et al. Non-alcoholic fatty liver disease and risk of fatal and non-fatal cardiovascular events: an updated systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2021;6(11):903913. DOI: 10.1016/s2468-1253(21)00308-3
  13. 13Bedogni G, Bellentani S, Miglioli L, et al. The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol. 2006;6:33. DOI: 10.1186/1471-230x-6-33
  14. 14Seo IH, Lee HS, Lee YJ. Fatty liver index as a predictor for incident type 2 diabetes in community-dwelling adults: longitudinal findings over 12 years. Cardiovasc Diabetol. 2022;21(1):209. DOI: 10.1186/s12933-022-01642-1
  15. 15Loprinzi PD, Addoh O. Predictive Validity of the American College of Cardiology/American Heart Association Pooled Cohort Equations in Predicting All-Cause and Cardiovascular Disease-Specific Mortality in a National Prospective Cohort Study of Adults in the United States. Mayo Clin Proc. 2016;91(6):763769. DOI: 10.1016/j.mayocp.2016.03.019
  16. 16Studenski SA, Peters KW, Alley DE, et al. The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci. 2014;69(5):547558. DOI: 10.1093/gerona/glu010
  17. 17Thygesen K, Alpert JS, Jaffe AS, et al. Fourth Universal Definition of Myocardial Infarction (2018). Circulation. 2018;138(20):e618e651. DOI: 10.1161/cir.0000000000000617
  18. 18Bashar H, Kobo O, Curzen N, Mamas MA. Association of myocardial injury with adverse long-term survival among cancer patients. Eur J Prev Cardiol. 2024. DOI: 10.1093/eurjpc/zwae116
  19. 19Hu J, Du Y, Zhou Y, Wang H. High sensitivity troponins and mortality in the population with metabolic dysfunction-associated steatotic liver disease. Sci. Rep. 2024;14(1):19541. DOI: 10.1038/s41598-024-70645-7
  20. 20Yki-Järvinen H. Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome. Lancet Diabetes Endocrinol. 2014;2(11):901910. DOI: 10.1016/S2213-8587(14)70032-4
  21. 21Silveira Rossi JL, Barbalho SM, Reverete de Araujo R, Bechara MD, Sloan KP, Sloan LA. Metabolic syndrome and cardiovascular diseases: Going beyond traditional risk factors. Diabetes Metab Res Rev. 2022;38(3):e3502. DOI: 10.1002/dmrr.3502
  22. 22Xia W, Yang N, Li Y. Analysis of Risk Factors for Adverse Cardiovascular Events in Elderly Patients with Acute Myocardial Infarction and Non-Alcoholic Fatty Liver Disease (NAFLD). Med. Sci. Monit. 2020;26:e922913. DOI: 10.12659/MSM.922913
  23. 23VanWagner LB, Wilcox JE, Colangelo LA, et al. Association of nonalcoholic fatty liver disease with subclinical myocardial remodeling and dysfunction: A population-based study. Hepatology (Baltimore, Md). 2015;62(3):773783. DOI: 10.1002/hep.27869
  24. 24Liu L, Cheng YT, Xu A, Cheung BMY. Association between high sensitivity cardiac troponin and mortality risk in the non-diabetic population: findings from the National Health and Nutrition Examination Survey. Cardiovasc. Diabetol.2023;22(1):296. DOI: 10.1186/s12933-023-02003-2
  25. 25Bisaccia G, Ricci F, Khanji MY, et al. Cardiovascular Morbidity and Mortality Related to Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis. Curr. Probl. Cardiol.2023;48(6):101643. DOI: 10.1016/j.cpcardiol.2023.101643
  26. 26Simon TG, Trejo MEP, McClelland R, et al. Circulating Interleukin-6 is a biomarker for coronary atherosclerosis in nonalcoholic fatty liver disease: Results from the Multi-Ethnic Study of Atherosclerosis. Int J Cardiol 2018;259:198204. DOI: 10.1016/j.ijcard.2018.01.046
  27. 27Abd Alamir M, Goyfman M, Chaus A, et al. The Correlation of Dyslipidemia with the Extent of Coronary Artery Disease in the Multiethnic Study of Atherosclerosis. J. Lipids. 2018;2018:5607349. DOI: 10.1155/2018/5607349
  28. 28Martin SS, Blaha MJ, Blankstein R, et al. Dyslipidemia, coronary artery calcium, and incident atherosclerotic cardiovascular disease: implications for statin therapy from the multi-ethnic study of atherosclerosis. Circulation. 2014;129(1):7786. DOI: 10.1161/circulationaha.113.003625
  29. 29Ma Y, Zhang L, Rong S, et al. Relation between gastric cancer and protein oxidation, DNA damage, and lipid peroxidation. Oxid. Med Cell Longev. 2013;2013:543760. DOI: 10.1155/2013/543760
  30. 30Neri M, Fineschi V, Di Paolo M, et al. Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction. Curr. Vasc. Pharmacol. 2015;13(1):2636. DOI: 10.2174/15701611113119990003
  31. 31Paradies G, Paradies V, Ruggiero FM, Petrosillo G. Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease. World J Gastroenterol. 2014;20(39):1420514218. DOI: 10.3748/wjg.v20.i39.14205
  32. 32Vlachopoulos C, Manesis E, Baou K, et al. Increased arterial stiffness and impaired endothelial function in nonalcoholic Fatty liver disease: a pilot study. Am. J. Hypertens. 2010;23(11):11831189. DOI: 10.1038/ajh.2010.144
  33. 33Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med. 2010;363(14):13411350. DOI: 10.1056/nejmra0912063
  34. 34Vanni E, Bugianesi E, Kotronen A, De Minicis S, Yki-Järvinen H, Svegliati-Baroni G. From the metabolic syndrome to NAFLD or vice versa? Dig Liver Dis. 2010;42(5):320330. DOI: 10.1016/j.dld.2010.01.016
  35. 35Rosato V, Masarone M, Dallio M, Federico A, Aglitti A, Persico M. NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome. Int J Environ Res Public Health. 2019;16(18). DOI: 10.3390/ijerph16183415
  36. 36Francque SM, van der Graaff D, Kwanten WJ. Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications. J Hepatol. 2016;65(2):425443. DOI: 10.1016/j.jhep.2016.04.005
  37. 37Ipsen DH, Lykkesfeldt J, Tveden-Nyborg P. Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease. Cell Mol Life Sci. 2018;75(18):33133327. DOI: 10.1007/s00018-018-2860-6
  38. 38Bril F, Barb D, Portillo-Sanchez P, et al. Metabolic and histological implications of intrahepatic triglyceride content in nonalcoholic fatty liver disease. Hepatology (Baltimore, Md). 2017;65(4):11321144. DOI: 10.1002/hep.28985
  39. 39Tilg H, Moschen AR, Roden M. NAFLD and diabetes mellitus. Nat. Rev. Gastroenterol. Hepatol. 2017;14(1):3242. DOI: 10.1038/nrgastro.2016.147
  40. 40Stefan N, Häring HU. The role of hepatokines in metabolism. Nat. Rev. Endocrinol. 2013;9(3):144152. DOI: 10.1038/nrendo.2012.258
  41. 41Meex RCR, Watt MJ. Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance. Nat. Rev. Endocrinol. 2017;13(9):509520. DOI: 10.1038/nrendo.2017.56
  42. 42EASL-EASD-EASO. Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol. 2016;64(6):13881402. DOI: 10.1016/j.jhep.2015.11.004
  43. 43Castellana M, Donghia R, Guerra V, et al. Performance of Fatty Liver Index in Identifying Non-Alcoholic Fatty Liver Disease in Population Studies. A Meta-Analysis. J. Clin. Med. 2021;10(9). DOI: 10.3390/jcm10091877
DOI: https://doi.org/10.5334/gh.1427 | Journal eISSN: 2211-8179
Language: English
Submitted on: Dec 3, 2024
Accepted on: Apr 16, 2025
Published on: Apr 29, 2025
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2025 Enfa Zhao, Hang Xie, Yuan Gao, Xiaolin Wen, Bingtian Dong, Chaoxue Zhang, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.