Causal Associations of Environmental Pollution and Cardiovascular Disease: A Two-Sample Mendelian Randomization Study

Figures & Tables

Significant MR analysis results in the discovery samples.

OUTCOME	EXPOSURE	METHOD	NO.SNP	OR	95%CI		p
OUTCOME	EXPOSURE	METHOD	NO.SNP	OR	LOWER	UPPER	p
Heart failure	Particulate matter air pollution (pm2.5)	IVW	47	1.40	1.02	1.93	0.039
		Maximum likelihood	47	1.42	1.14	1.76	0.002
		MR Egger	47	1.20	0.50	2.88	0.689
		Weighted median	47	1.17	0.85	1.62	0.344
		Weighted mode	47	1.19	0.74	1.94	0.475
Hypertension	Particulate matter air pollution (pm10)	IVW	27	1.45	1.02	2.05	0.036
		Maximum likelihood	27	1.47	1.03	2.11	0.033
		MR Egger	27	1.26	0.61	2.58	0.542
		Weighted median	27	1.45	0.88	2.38	0.142
		Weighted mode	27	1.65	0.67	4.11	0.288
Atrial fibrillation	Particulate matter air pollution (pm10)	IVW	27	1.41	1.03	1.94	0.035
		Maximum likelihood	27	1.44	1.10	1.89	0.008
		MR Egger	27	1.53	0.75	3.13	0.252
		Weighted median	27	1.29	0.87	1.91	0.209
		Weighted mode	27	1.23	0.55	2.75	0.622

Horizontal pleiotropy test and Heterogeneity test for significant MR analysis results.