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Causal Associations of DNA Methylation and Cardiovascular Disease: A Two-Sample Mendelian Randomization Study Cover

Causal Associations of DNA Methylation and Cardiovascular Disease: A Two-Sample Mendelian Randomization Study

Global Heart
Volume 19 (2024): Issue 1
By: Hui Gao,  Jiahai Li,  Qiaoli Ma,  Qinghui Zhang,  Man Li and  Xiaoliang Hu  
Open Access
|May 2024

References

  1. 1Tsao, CW, Aday AW, Almarzooq ZI, Alonso A, Beaton AZ, Bittencourt MS, et al. Heart disease and stroke statistics-2022 update: A report from the American Heart Association. Circulation. 2022 Feb 22; 145(8): e153–e639. Epub 2022 Jan 26. Erratum in: Circulation. 2022 Sep 6. 146(10): e141. PMID: 35078371. DOI: 10.1161/CIR.0000000000001052
    Back to article
  2. 2GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020 Oct 17; 396(10258): 1204–1222. Erratum in: Lancet. 2020 Nov 14. 396(10262): 1562. PMID: 33069326; PMCID: PMC7567026. DOI: 10.1016/S0140-6736(20)30925-9
    Back to article
  3. 3Ezzati M, Obermeyer Z, Tzoulaki I, Mayosi BM, Elliott P, Leon DA. Contributions of risk factors and medical care to cardiovascular mortality trends. Nature Reviews Cardiology. 2015 Sep; 12(9): 508–30. Epub 2015 Jun 16. PMID: 26076950; PMCID: PMC4945698. DOI: 10.1038/nrcardio.2015.82
    Back to article
  4. 4Yousefi PD, Suderman M, Langdon R, Whitehurst O, Davey Smith G, Relton CL. DNA methylation-based predictors of health: Applications and statistical considerations. Nat Rev Genet. 2022 Jun; 23(6): 369–383. Epub 2022 Mar 18. PMID: 35304597. DOI: 10.1038/s41576-022-00465-w
    Back to article
  5. 5Westerman K, Sebastiani P, Jacques P, Liu S, DeMeo D, Ordovás JM. DNA methylation modules associate with incident cardiovascular disease and cumulative risk factor exposure. Clin Epigenetics. 2019 Oct 15. 11(1): 142. PMID: 31615550; PMCID: PMC6792327. DOI: 10.1186/s13148-019-0705-2
    Back to article
  6. 6Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics. Science. 2001 Aug 10; 293(5532): 1068–70. PMID: 11498573. DOI: 10.1126/science.1063852
    Back to article
  7. 7Wolffe AP, Matzke MA. Epigenetics: Regulation through repression. Science. 1999 Oct 15; 286(5439): 481–6. PMID: 10521337. DOI: 10.1126/science.286.5439.481
    Back to article
  8. 8Schiattarella GG, Madonna R, Van Linthout S, Thum T, Schulz R, Ferdinandy P, Perrino C. Epigenetic modulation of vascular diseases: Assessing the evidence and exploring the opportunities. Vascul Pharmacol. 2018 Mar 14; S1537–1891(17): 30468–8. Epub ahead of print. PMID: 29548901. DOI: 10.1016/j.vph.2018.02.009
    Back to article
  9. 9Fernández-Sanlés A, Sayols-Baixeras S, Subirana I, Degano IR, Elosua R. Association between DNA methylation and coronary heart disease or other atherosclerotic events: A systematic review. Atherosclerosis. 2017 Aug; 263: 325–333. Epub 2017 May 18. PMID: 28577936. DOI: 10.1016/j.atherosclerosis.2017.05.022
    Back to article
  10. 10Domingo-Relloso A, Makhani K, Riffo-Campos AL, Tellez-Plaza M, Klein KO, Subedi P, et al. Arsenic exposure, blood DNA methylation, and cardiovascular disease. Circ Res. 2022 Jul 8; 131(2): e51–e69. Epub 2022 Jun 6. PMID: 35658476. PMCID: PMC10203287. DOI: 10.1161/CIRCRESAHA.122.320991
    Back to article
  11. 11Mao X, Huang C, Wang Y, Mao S, Li Z, Zou W, Liao Z. Association between dietary habits and pancreatitis among individuals of European ancestry: A two-sample Mendelian randomization study. Nutrients. 2023 Feb 24. 15(5): 1153. PMID: 36904153; PMCID: PMC10004739. DOI: 10.3390/nu15051153
    Back to article
  12. 12Budu-Aggrey A, Paternoster L. Research techniques made simple: Using genetic variants for randomization. J Invest Dermatol. 2019 Jul; 139(7): 1416–1421.e1. PMID: 31230636. DOI: 10.1016/j.jid.2019.03.1138
    Back to article
  13. 13Burgess S, Scott RA, Timpson NJ, Davey Smith G, Thompson SG, EPIC- InterAct Consortium. Using published data in Mendelian randomization: A blueprint for efficient identification of causal risk factors. Eur J Epidemiol. 2015 Jul; 30(7): 543–52. Epub 2015 Mar 15. PMID: 25773750; PMCID: PMC4516908. DOI: 10.1007/s10654-015-0011-z
    Back to article
  14. 14Dimou NL, Tsilidis KK. A primer in Mendelian randomization methodology with a focus on utilizing published summary association data. Methods Mol Biol. 2018; 1793: 211–230. PMID: 29876899. DOI: 10.1007/978-1-4939-7868-7_13
    Back to article
  15. 15Hingorani A, Humphries S. Nature’s randomised trials. Lancet. 2005 Dec 3; 366(9501): 1906–8. PMID: 16325682. DOI: 10.1016/S0140-6736(05)67767-7
    Back to article
  16. 16Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA, et al. Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: The STROBE-MR statement. JAMA. 2021 Oct 26. 326(16): 1614–1621. PMID: 34698778. DOI: 10.1001/jama.2021.18236
    Back to article
  17. 17McCartney DL, Min JL, Richmond RC, Lu AT, Sobczyk MK, Davies G, et al. Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging. Genome Biol. 2021 Jun 29; 22(1): 194. PMID: 34187551. PMCID: PMC8243879. DOI: 10.1186/s13059-021-02398-9
    Back to article
  18. 18Warnecke RB, Oh A, Breen N, Gehlert S, Paskett E, Tucker KL, et al. Approaching health disparities from a population perspective: The National Institutes of Health Centers for Population Health and Health Disparities. Am J Public Health. 2008 Sep; 98(9): 1608–15. Epub 2008 Jul 16. PMID: 18633099. PMCID: PMC2509592. DOI: 10.2105/AJPH.2006.102525
    Back to article
  19. 19Giurgescu C, Nowak AL, Gillespie S, Nolan TS, Anderson CM, Ford JL, et al. Neighborhood environment and DNA methylation: Implications for cardiovascular disease risk. J Urban Health. 2019 Mar; 96(Suppl 1): 23–34. PMID: 30635842. PMCID: PMC6430282. DOI: 10.1007/s11524-018-00341-1
    Back to article
  20. 20Westerman KE, Ordovás JM. DNA methylation and incident cardiovascular disease. Curr Opin Clin Nutr Metab Care. 2020 Jul; 23(4): 236–240. PMID: 32487875. DOI: 10.1097/MCO.0000000000000659
    Back to article
  21. 21Palou-Márquez G, Subirana I, Nonell L, Fernández-Sanlés A, Elosua R. DNA methylation and gene expression integration in cardiovascular disease. Clin Epigenetics. 2021 Apr 9. 13(1): 75. PMID: 33836805; PMCID: PMC8034168. DOI: 10.1186/s13148-021-01064-y
    Back to article
  22. 22Navas-Acien A, Domingo-Relloso A, Subedi P, Riffo-Campos AL, Xia R, Gomez L, et al. Blood DNA methylation and incident coronary heart disease: Evidence from the Strong Heart Study. JAMA Cardiol. 2021 Nov 1; 6(11): 1237–1246. PMID: 34347013. PMCID: PMC8340006. DOI: 10.1001/jamacardio.2021.2704
    Back to article
  23. 23Westerman KE, Ordovás JM. DNA methylation and incident cardiovascular disease. Curr Opin Clin Nutr Metab Care. 2020 Jul; 23(4): 236–240. PMID: 32487875. DOI: 10.1097/MCO.0000000000000659
    Back to article
  24. 24Wang Y, Eliot MN, Wellenius GA. Short-term changes in ambient particulate matter and risk of stroke: A systematic review and meta-analysis. J Am Heart Assoc. 2014 Aug 7. 3(4): e000983. PMID: 25103204; PMCID: PMC4310387. DOI: 10.1161/JAHA.114.000983
    Back to article
  25. 25Omar M, Alexiou M, Rekhi UR, Lehmann K, Bhardwaj A, Delyea C, et al. DNA methylation changes underlie the long-term association between periodontitis and atherosclerotic cardiovascular disease. Front Cardiovasc Med. 2023 Apr 21; 10: 1164499. PMID: 37153468. PMCID: PMC10160482. DOI: 10.3389/fcvm.2023.1164499
    Back to article
  26. 26Cash HL, McGarvey ST, Houseman EA, Marsit CJ, Hawley NL, Lambert-Messerlian GM, et al. Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan Islanders. Epigenetics. 2011 Oct 1; 6(10): 1257–64. Epub 2011 Oct 1. PMID: 21937883. PMCID: PMC3225843. DOI: 10.4161/epi.6.10.17728
    Back to article
  27. 27Kim M, Long TI, Arakawa K, Wang R, Yu MC, Laird PW. DNA methylation as a biomarker for cardiovascular disease risk. PLoS One. 2010 Mar 15. 5(3): e9692. PMID: 20300621; PMCID: PMC2837739. DOI: 10.1371/journal.pone.0009692
    Back to article
  28. 28Cuadrat RRC, Kratzer A, Arnal HG, Rathgeber AC, Wreczycka K, Blume A, et al. Cardiovascular disease biomarkers derived from circulating cell-free DNA methylation. NAR Genom Bioinform. 2023 Jun 28; 5(2): lqad061. PMID: 37388821. PMCID: PMC10304763. DOI: 10.1093/nargab/lqad061
    Back to article
  29. 29He Y, Chen X, Liu M, Zuo L, Zhai Z, Zhou L, et al. The potential DNA methylation markers of cardiovascular disease in patients with type 2 diabetes. BMC Med Genomics. 2023 Oct 12; 16(1): 242. PMID: 37828521. PMCID: PMC10568935. DOI: 10.1186/s12920-023-01689-3
    Back to article
  30. 30Armstrong NJ, Mather KA, Thalamuthu A, Wright MJ, Trollor JN, Ames D, et al. Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks. Epigenomics. 2017 May; 9(5): 689–700. Epub 2017 May 4. PMID: 28470125. DOI: 10.2217/epi-2016-0179
    Back to article
  31. 31Roberts JD, Vittinghoff E, Lu AT, Alonso A, Wang B, Sitlani CM, et al. Epigenetic age and the risk of incident atrial fibrillation. Circulation. 2021 Dec 14; 144(24): 1899–1911. Epub 2021 Sep 30. PMID: 34587750. PMCID: PMC8671333. DOI: 10.1161/CIRCULATIONAHA.121.056456
    Back to article
  32. 32Nacarelli T, Azar A, Potnis M, Johannes G, Mell J, Johnson FB, et al. The methyltransferase enzymes KMT2D, SETD1B, and ASH1 L are key mediators of both metabolic and epigenetic changes during cellular senescence. Mol Biol Cell. 2022 May 1; 33(5): ar36. Epub 2022 Feb 23. PMID: 35196069. PMCID: PMC9282020. DOI: 10.1091/mbc.E20-08-0523
    Back to article
  33. 33Grzeczka A, Graczyk S, Kordowitzki P. DNA methylation and telomeres—Their impact on the occurrence of atrial fibrillation during cardiac aging. Int J Mol Sci. 2023 Oct 28. 24(21): 15699. PMID: 37958686; PMCID: PMC10650750. DOI: 10.3390/ijms242115699
    Back to article
  34. 34Hoff K, Lemme M, Kahlert AK, Runde K, Audain E, Schuster D, et al. DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs. Clin Epigenetics. 2019 Jun 11; 11(1): 89. PMID: 31186048. PMCID: PMC6560887. DOI: 10.1186/s13148-019-0679-0
    Back to article
  35. 35Hall AW, Chaffin M, Roselli C, Lin H, Lubitz SA, Bianchi V, et al. Epigenetic analyses of human left atrial tissue identifies gene networks underlying atrial fibrillation. Circ Genom Precis Med. 2020 Dec; 13(6): e003085. Epub 2020 Nov 6. PMID: 33155827. PMCID: PMC8240092. DOI: 10.1161/CIRCGEN.120.003085
    Back to article
  36. 36Tao H, Song ZY, Ding XS, Yang JJ, Shi KH, Li J. Epigenetic signatures in cardiac fibrosis, special emphasis on DNA methylation and histone modification. Heart Fail Rev. 2018 Sep; 23(5): 789–799. PMID: 29607455. DOI: 10.1007/s10741-018-9694-z
    Back to article
  37. 37Sohns C, Marrouche NF. Atrial fibrillation and cardiac fibrosis. Eur Heart J. 2020 Mar 7; 41(10): 1123–1131. PMID: 31713590. DOI: 10.1093/eurheartj/ehz786
    Back to article
  38. 38Reese-Petersen AL, Olesen MS, Karsdal MA, Svendsen JH, Genovese F. Atrial fibrillation and cardiac fibrosis: A review on the potential of extracellular matrix proteins as biomarkers. Matrix Biol. 2020 Sep; 91–92: 188–203. Epub 2020 Mar 20. PMID: 32205152. DOI: 10.1016/j.matbio.2020.03.005
    Back to article
  39. 39Pepin ME, Drakos S, Ha CM, Tristani-Firouzi M, Selzman CH, Fang JC, et al. DNA methylation reprograms cardiac metabolic gene expression in end-stage human heart failure. Am J Physiol Heart Circ Physiol. 2019 Oct 1; 317(4): H674–H684. Epub 2019 Jul 12. PMID: 31298559. PMCID: PMC6843013. DOI: 10.1152/ajpheart.00016.2019
    Back to article
  40. 40Bain CR, Ziemann M, Kaspi A, Khan AW, Taylor R, Trahair H, et al. DNA methylation patterns from peripheral blood separate coronary artery disease patients with and without heart failure. ESC Heart Fail. 2020 Oct; 7(5): 2468–2478. Epub 2020 Jul 2. PMID: 32618141. PMCID: PMC7524212. DOI: 10.1002/ehf2.12810
    Back to article
  41. 41Robinson EL, Ameri P, Delrue L, Vanderheyden M, Bartunek J, Altieri P, et al. Differential expression of epigenetic modifiers in early and late cardiotoxic heart failure reveals DNA methylation as a key regulator of cardiotoxicity. Front Cardiovasc Med. 2023 Mar 9; 10: 884174. PMID: 36970338. PMCID: PMC10034031. DOI: 10.3389/fcvm.2023.884174
    Back to article
  42. 42Gibb AA, Hill BG. Metabolic coordination of physiological and pathological cardiac remodeling. Circ Res. 2018 Jun 22. 123(1): 107–128. PMID: 29929976; PMCID: PMC6023588. DOI: 10.1161/CIRCRESAHA.118.312017
    Back to article
  43. 43Kologrivova I, Shtatolkina M, Suslova T, Ryabov V. Cells of the immune system in cardiac remodeling: Main players in resolution of inflammation and repair after myocardial infarction. Front Immunol. 2021 Apr 2. 12: 664457. PMID: 33868315; PMCID: PMC8050340. DOI: 10.3389/fimmu.2021.664457
    Back to article
DOI: https://doi.org/10.5334/gh.1324 | Journal eISSN: 2211-8179
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Language: English
Submitted on: Dec 12, 2023
Accepted on: Apr 16, 2024
Published on: May 14, 2024
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
Mendelian randomization,
methylation,
cardiovascular disease

© 2024 Hui Gao, Jiahai Li, Qiaoli Ma, Qinghui Zhang, Man Li, Xiaoliang Hu, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.

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