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Illness Severity in Psychotic Disorders Amplifies Anterior Insula’s Sensitivity to Unreciprocated Smiles Cover

Illness Severity in Psychotic Disorders Amplifies Anterior Insula’s Sensitivity to Unreciprocated Smiles

Open Access
|Dec 2025

References

  1. Adams, R. A. (2019). Cortical Disinhibition, Attractor Dynamics, and Belief Updating in Schizophrenia. In V. Cutsuridis (Ed.), Multiscale Models of Brain Disorders (pp. 8189). Springer International Publishing. 10.1007/978-3-030-18830-6_8
  2. Aleman, A., Kahn, R. S., & Selten, J.-P. (2003). Sex differences in the risk of schizophrenia: Evidence from meta-analysis. Archives of General Psychiatry, 60(6), 565571. 10.1001/archpsyc.60.6.565
  3. Allen, J. S., Matsunaga, K., Hacisalihzade, S., & Stark, L. (1990). Smooth pursuit eye movements of normal and schizophrenic subjects tracking an unpredictable target. Biological Psychiatry, 28(8), 705720. 10.1016/0006-3223(90)90457-D
  4. Alvino, C., Kohler, C., Barrett, F., Gur, R. E., Gur, R. C., & Verma, R. (2007). Computerized Measurement of Facial Expression of Emotions in Schizophrenia. Journal of Neuroscience Methods, 163(2), 350361. 10.1016/j.jneumeth.2007.03.002
  5. Baltrusaitis, T., Zadeh, A., Lim, Y. C., & Morency, L. (2018). OpenFace 2.0: Facial Behavior Analysis Toolkit. 2018 13th IEEE International Conference on Automatic Face & Gesture Recognition, 5966.
  6. Benjamini, Y., & Hochberg, Y. (1995). Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. Journal of the Royal Statistical Society. Series B (Methodological), 57(1), 289300. 10.1111/j.2517-6161.1995.tb02031.x
  7. Benoit, A., Bodnar, M., Malla, A., Joober, R., & Lepage, M. (2012). The Structural Neural Substrates of Persistent Negative Symptoms in First-Episode of Non-Affective Psychosis: A Voxel-Based Morphometry Study. Frontiers in Psychiatry, 3. 10.3389/fpsyt.2012.00042
  8. Benuzzi, F., Ballotta, D., Casadio, C., Zanelli, V., Porro, C. A., Nichelli, P. F., & Lui, F. (2023). “When You’re Smiling”: How Posed Facial Expressions Affect Visual Recognition of Emotions. Brain Sciences, 13(4), 668. 10.3390/brainsci13040668
  9. Berenbaum, H., & Oltmanns, T. F. (1992). Emotional experience and expression in schizophrenia and depression. Journal of Abnormal Psychology, 101(1), 3744. 10.1037/0021-843X.101.1.37
  10. Breakspear, M. (2013). Dynamic and stochastic models of neuroimaging data: A comment on Lohmann et al. NeuroImage, 75, 270274. 10.1016/j.neuroimage.2012.02.047
  11. Dale, A. M. (1999). Optimal experimental design for event-related fMRI. Human Brain Mapping, 8(2–3), 109114. 10.1002/(SICI)1097-0193(1999)8:2/3<;109::AID-HBM7>3.0.CO;2-W
  12. Deserno, L., Heinz, A., & Schlagenhauf, F. (2017). Computational approaches to schizophrenia: A perspective on negative symptoms. Schizophrenia Research, 186, 4654. 10.1016/j.schres.2016.10.004
  13. Ekman, P., Friesen, W. V., Friesen, W. V., & Hager, J. (1978). Facial action coding system: A technique for the measurement of facial movement. https://www.scienceopen.com/document?vid=759f6f74-7ccd-47b5-904a-25ca0f29ea90
  14. Fenton, W. S., & McGlashan, T. H. (1991). Natural History of Schizophrenia Subtypes: II. Positive and Negative Symptoms and Long-term Course. Archives of General Psychiatry, 48(11), 978986. 10.1001/archpsyc.1991.01810350018003
  15. Fletcher, P. C., & Frith, C. D. (2009). Perceiving is believing: A Bayesian approach to explaining the positive symptoms of schizophrenia. Nature Reviews Neuroscience, 10(1), Article 1. 10.1038/nrn2536
  16. Foussias, G., Agid, O., Fervaha, G., & Remington, G. (2014). Negative symptoms of schizophrenia: Clinical features, relevance to real world functioning and specificity versus other CNS disorders. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 24(5), 693709. 10.1016/j.euroneuro.2013.10.017
  17. Friston, K. (2005). A theory of cortical responses. Philosophical Transactions of the Royal Society B: Biological Sciences, 360(1456), 815836. 10.1098/rstb.2005.1622
  18. Friston, K. J., Harrison, L., & Penny, W. (2003). Dynamic causal modelling. NeuroImage, 19(4), 12731302. 10.1016/S1053-8119(03)00202-7
  19. Friston, K. J., Stephan, K. E., Montague, R., & Dolan, R. J. (2014). Computational psychiatry: The brain as a phantastic organ. The Lancet Psychiatry, 1(2), 148158. 10.1016/S2215-0366(14)70275-5
  20. Galderisi, S., Mucci, A., Buchanan, R. W., & Arango, C. (2018). Negative symptoms of schizophrenia: New developments and unanswered research questions. The Lancet. Psychiatry, 5(8), 664677. 10.1016/S2215-0366(18)30050-6
  21. Gold, J. M., Waltz, J. A., Matveeva, T. M., Kasanova, Z., Strauss, G. P., Herbener, E. S., Collins, A. G. E., & Frank, M. J. (2012). Negative symptoms and the failure to represent the expected reward value of actions: Behavioral and computational modeling evidence. Archives of General Psychiatry, 69(2), 129138. 10.1001/archgenpsychiatry.2011.1269
  22. Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery, and Psychiatry, 23(1), 5662. 10.1136/jnnp.23.1.56
  23. Hamm, J., Kohler, C. G., Gur, R. C., & Verma, R. (2011). Automated Facial Action Coding System for dynamic analysis of facial expressions in neuropsychiatric disorders. Journal of Neuroscience Methods, 200(2), 237256. 10.1016/j.jneumeth.2011.06.023
  24. Hartmann, M. N., Hager, O. M., Reimann, A. V., Chumbley, J. R., Kirschner, M., Seifritz, E., Tobler, P. N., & Kaiser, S. (2015). Apathy But Not Diminished Expression in Schizophrenia Is Associated With Discounting of Monetary Rewards by Physical Effort. Schizophrenia Bulletin, 41(2), 503512. 10.1093/schbul/sbu102
  25. Hawley, C., Fineberg, N., Roberts, A., Baldwin, D., Sahadevan, A., & Sharman, V. (2003). The use of the Simpson Angus Scale for the assessment of movement disorder: A training guide. International Journal of Psychiatry in Clinical Practice, 7(4), 3492257. 10.1080/13651500310002986
  26. Heerey, E. A., & Crossley, H. M. (2013). Predictive and Reactive Mechanisms in Smile Reciprocity. Psychological Science, 24(8), 14461455. 10.1177/0956797612472203
  27. Horan, W. P., Iacoboni, M., Cross, K. A., Korb, A., Lee, J., Nori, P., Quintana, J., Wynn, J. K., & Green, M. F. (2014). Self-reported empathy and neural activity during action imitation and observation in schizophrenia. NeuroImage. Clinical, 5, 100108. 10.1016/j.nicl.2014.06.006
  28. Iacoboni, M., Woods, R. P., Brass, M., Bekkering, H., Mazziotta, J. C., & Rizzolatti, G. (1999). Cortical mechanisms of human imitation. Science (New York, N.Y.), 286(5449), 25262528. 10.1126/science.286.5449.2526
  29. Jeganathan, J., & Breakspear, M. (2021). An active inference perspective on the negative symptoms of schizophrenia. The Lancet Psychiatry. 10.1016/S2215-0366(20)30527-7
  30. Kahan, J., & Foltynie, T. (2013). Understanding DCM: Ten simple rules for the clinician. NeuroImage, 83, 542549. 10.1016/j.neuroimage.2013.07.008
  31. Kanwisher, N., McDermott, J., & Chun, M. M. (1997). The Fusiform Face Area: A Module in Human Extrastriate Cortex Specialized for Face Perception. Journal of Neuroscience, 17(11), 43024311. 10.1523/JNEUROSCI.17-11-04302.1997
  32. Kay, S. R., Fiszbein, A., & Opler, L. A. (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin, 13(2), 261276. 10.1093/schbul/13.2.261
  33. Kirkpatrick, B., Strauss, G. P., Nguyen, L., Fischer, B. A., Daniel, D. G., Cienfuegos, A., & Marder, S. R. (2011). The Brief Negative Symptom Scale: Psychometric Properties. Schizophrenia Bulletin, 37(2), 300305. 10.1093/schbul/sbq059
  34. Kohler, C. G., Martin, E. A., Stolar, N., Barrett, F. S., Verma, R., Brensinger, C., Bilker, W., Gur, R. E., & Gur, R. C. (2008). Static posed and evoked facial expressions of emotions in schizophrenia. Schizophrenia Research, 105(1), 4960. 10.1016/j.schres.2008.05.010
  35. Krippl, M., Karim, A. A., & Brechmann, A. (2015). Neuronal correlates of voluntary facial movements. Frontiers in Human Neuroscience, 9, 598. 10.3389/fnhum.2015.00598
  36. Lader, M. (2000). Rating Scales in Schizophrenia. CNS Drugs, 14(1), 2332. 10.2165/00023210-200014010-00003
  37. LaFrance, M., Hecht, M. A., & Paluck, E. L. (2003). The contingent smile: A meta-analysis of sex differences in smiling. Psychological Bulletin, 129(2), 305334. 10.1037/0033-2909.129.2.305
  38. Lee, J. S., Chun, J. W., Yoon, S. Y., Park, H.-J., & Kim, J.-J. (2014). Involvement of the mirror neuron system in blunted affect in schizophrenia. Schizophrenia Research, 152(1), 268274. 10.1016/j.schres.2013.10.043
  39. Lohmann, G., Erfurth, K., Müller, K., & Turner, R. (2012). Critical comments on dynamic causal modelling. NeuroImage, 59(3), 23222329. 10.1016/j.neuroimage.2011.09.025
  40. Lundqvist, D., Flykt, A., & Ohman, A. (1998). The Karolinska Directed Emotional Faces—KDEF (No. CD ROM from the Department of Clinical Neuroscience, Psychology section, Karolinska Institutet) [Dataset]. 10.1037/t27732-000
  41. Macuga, K. L., & Frey, S. H. (2011). Selective responses in right inferior frontal and supramarginal gyri differentiate between observed movements of oneself vs. Another. Neuropsychologia, 49(5), 12021207. 10.1016/j.neuropsychologia.2011.01.005
  42. Malaspina, D., Walsh-Messinger, J., Gaebel, W., Smith, L. M., Gorun, A., Prudent, V., Antonius, D., & Trémeau, F. (2014). Negative symptoms, past and present: A historical perspective and moving to DSM-5. European Neuropsychopharmacology, 24(5), 710724. 10.1016/j.euroneuro.2013.10.018
  43. Marsh, A. A., Ambady, N., & Kleck, R. E. (2005). The Effects of Fear and Anger Facial Expressions on Approach- and Avoidance-Related Behaviors. Emotion, 5(1), 119124. 10.1037/1528-3542.5.1.119
  44. Morosini, P. l., Magliano, L., Brambilla, L., Ugolini, S., & Pioli, R. (2000). Development, reliability and acceptability of a new version of the DSM-IV Social and Occupational Functioning Assessment Scale (SOFAS) to assess routine social funtioning. Acta Psychiatrica Scandinavica, 101(4), 323329. 10.1034/j.1600-0447.2000.101004323.x
  45. Paulus, M. P., & Stein, M. B. (2006). An Insular View of Anxiety. Biological Psychiatry, 60(4), 383387. 10.1016/j.biopsych.2006.03.042
  46. Pinna, F., Deriu, L., Diana, E., Perra, V., Randaccio, R. P., Sanna, L., Tusconi, M., Carpiniello, B., & Cagliari Recovery Study Group. (2015). Clinical Global Impression-severity score as a reliable measure for routine evaluation of remission in schizophrenia and schizoaffective disorders. Annals of General Psychiatry, 14(1), 6. 10.1186/s12991-015-0042-6
  47. Piskulic, D., Addington, J., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., Heinssen, R., Perkins, D. O., Seidman, L. J., Tsuang, M. T., Walker, E. F., Woods, S. W., & McGlashan, T. H. (2012). Negative symptoms in individuals at clinical high risk of psychosis. Psychiatry Research, 196(2–3), 220224. 10.1016/j.psychres.2012.02.018
  48. Pohl, A., Anders, S., Schulte-Rüther, M., Mathiak, K., & Kircher, T. (2013). Positive facial affect—An fMRI study on the involvement of insula and amygdala. PloS One, 8(8), e69886. 10.1371/journal.pone.0069886
  49. Pruim, R. H. R., Mennes, M., van Rooij, D., Llera, A., Buitelaar, J. K., & Beckmann, C. F. (2015). ICA-AROMA: A robust ICA-based strategy for removing motion artifacts from fMRI data. NeuroImage, 112, 267277. 10.1016/j.neuroimage.2015.02.064
  50. Reed, E. J., Uddenberg, S., Suthaharan, P., Mathys, C. D., Taylor, J. R., Groman, S. M., & Corlett, P. R. (2020). Paranoia as a deficit in non-social belief updating. eLife, 9, e56345. 10.7554/eLife.56345
  51. Samara, M. T., Engel, R. R., Millier, A., Kandenwein, J., Toumi, M., & Leucht, S. (2014). Equipercentile linking of scales measuring functioning and symptoms: Examining the GAF, SOFAS, CGI-S, and PANSS. European Neuropsychopharmacology, 24(11), 17671772. 10.1016/j.euroneuro.2014.08.009
  52. Shackman, A. J., McMenamin, B. W., Maxwell, J. S., Greischar, L. L., & Davidson, R. J. (2009). Right Dorsolateral Prefrontal Cortical Activity and Behavioral Inhibition. Psychological Science, 20(12), 15001506. 10.1111/j.1467-9280.2009.02476.x
  53. Sheitman, B. B., & Lieberman, J. A. (1998). The natural history and pathophysiology of treatment resistant schizophrenia. Journal of Psychiatric Research, 32(3), 143150. 10.1016/S0022-3956(97)00052-6
  54. Stip, E., Fahim, C., Liddle, P., Mancini-Marïe, A., Mensour, B., Bentaleb, L. A., & Beauregard, M. (2005). Neural correlates of sad feelings in schizophrenia with and without blunted affect. Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie, 50(14), 909917. 10.1177/070674370505001405
  55. Strauss, G. P., Waltz, J. A., & Gold, J. M. (2014). A Review of Reward Processing and Motivational Impairment in Schizophrenia. Schizophrenia Bulletin, 40(Suppl 2), S107S116. 10.1093/schbul/sbt197
  56. Tron, T., Peled, A., Grinsphoon, A., & Weinshall, D. (2016). Facial expressions and flat affect in schizophrenia, automatic analysis from depth camera data. 2016 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI), 220223. 10.1109/BHI.2016.7455874
  57. van den Bos, W., van Dijk, E., Westenberg, M., Rombouts, S. A. R. B., & Crone, E. A. (2011). Changing brains, changing perspectives: The neurocognitive development of reciprocity. Psychological Science, 22(1), 6070. 10.1177/0956797610391102
  58. Wang, P., Barrett, F., Martin, E., Milanova, M., Gur, R. E., Gur, R. C., Kohler, C., & Verma, R. (2008). Automated Video Based Facial Expression Analysis of Neuropsychiatric Disorders. Journal of Neuroscience Methods, 168(1), 224238. 10.1016/j.jneumeth.2007.09.030
  59. Weigel, L., Wehr, S., Galderisi, S., Mucci, A., Davis, J. M., & Leucht, S. (2024). Clinician-Reported Negative Symptom Scales: A Systematic Review of Measurement Properties. Schizophrenia Bulletin, sbae168. 10.1093/schbul/sbae168
  60. Wolfgang Fleischhacker, W. (2016). The usefulness of rating scales in patients with schizophrenia. Acta Psychiatrica Scandinavica, 133(6), 435435. 10.1111/acps.12588
DOI: https://doi.org/10.5334/cpsy.142 | Journal eISSN: 2379-6227
Language: English
Submitted on: Mar 6, 2025
|
Accepted on: Nov 15, 2025
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Published on: Dec 30, 2025
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2025 Jayson Jeganathan, Megan E. J. Campbell, Renate Thienel, Nikitas C. Koussis, Bryan Paton, Katharina V. Wellstein, Michael Breakspear, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.