References
- Medzhitov R Origin and physiological roles of inflammation Nature 2008 454 7203 428 35 10.1038/nature07201
- Kotas ME Medzhitov R Homeostasis, inflammation, and disease susceptibility Cell 2015 160 5 816 27 10.1016/j.cell.2015.02.010
- Rittirsch D Flierl MA Ward PA Harmful molecular mechanisms in sepsis Nat Rev Immunol 2008 8 10 776 87 10.1038/nri2402
- Chan AC Carter PJ Therapeutic antibodies for autoimmunity and inflammation Nat Rev Immunol 2010 10 5 301 16 10.1038/nri2761
- Barnes PJ Pathophysiology of allergic inflammation Immunol Rev 2011 242 1 31 50 10.1111/j.1600-065X.2011.01020.x
- Parrillo JE Pathogenetic mechanisms of septic shock N Engl J Med 1993 328 20 1471 7 10.1056/NEJM199305203282008
- Grivennikov SI Greten FR Karin M Immunity, inflammation, and cancer Cell 2010 140 6 883 99 10.1016/j.cell.2010.01.025
- Coussens LM Werb Z Inflammation and cancer Nature 2002 420 6917 860 7 10.1038/nature01322
- Martinez JC Otley CC The management of melanoma and nonmelanoma skin cancer: a review for the primary care physician Mayo Clin Proc 2001 76 12 1253 65 10.4065/76.12.1253
- Siegel RL Miller KD Jemal A Cancer statistics, 2015 CA Cancer J Clin 2015 65 1 5 29 10.3322/caac.21254
- Ferlay J Soerjomataram I Dikshit R Eser S Mathers C Rebelo M Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 Int J Cancer 2015 136 5 E359 86 10.1002/ijc.29210
- Maru GB Gandhi K Ramchandani A Kumar G The role of inflammation in skin cancer Adv Exp Med Biol 2014 816 437 69 10.1007/978-3-0348-0837-8_17
- Lund AW Medler TR Leachman SA Coussens LM Lymphatic Vessels, Inflammation, and Immunity in Skin Cancer Cancer Discov 2015
- Pfeifer GP Besaratinia A UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer Photochem Photobiol Sci 2012 11 1 90 7 10.1039/C1PP05144J
- Marteijn JA Lans H Vermeulen W Hoeijmakers JH Understanding nucleotide excision repair and its roles in cancer and ageing Nat Rev Mol Cell Biol 2014 15 7 465 81 10.1038/nrm3822
- Clydesdale GJ Dandie GW Muller HK Ultraviolet light induced injury: immunological and inflammatory effects Immunol Cell Biol 2001 79 6 547 68 10.1046/j.1440-1711.2001.01047.x
- Buckman SY Gresham A Hale P Hruza G Anast J Masferrer J COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer Carcinogenesis 1998 19 5 723 9 10.1093/carcin/19.5.723
- Beissert S Schwarz T Mechanisms involved in ultraviolet light-induced immunosuppression J Investig Dermatol Symp Proc 1999 4 1 61 4 10.1038/sj.jidsp.5640183
- Balkwill F Mantovani A Inflammation and cancer: back to Virchow? Lancet 2001 357 9255 539 45 10.1016/S0140-6736(00)04046-0
- Mantovani A Allavena P Sica A Balkwill F Cancer-related inflammation Nature 2008 454 7203 436 44 10.1038/nature07205
- de Visser KE Eichten A Coussens LM Paradoxical roles of the immune system during cancer development Nat Rev Cancer 2006 6 1 24 37 10.1038/nrc1782
- Schreiber RD Old LJ Smyth MJ Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion Science 2011 331 6024 1565 70 10.1126/science.1203486
- Hanahan D Weinberg RA Hallmarks of cancer: the next generation Cell 2011 144 5 646 74 10.1016/j.cell.2011.02.013
- Kalluri R Zeisberg M Fibroblasts in cancer Nat Rev Cancer 2006 6 5 392 401 10.1038/nrc1877
- El-Serag HB Epidemiology of viral hepatitis and hepatocellular carcinoma Gastroenterology 2012 142 6 1264 73 e1
- An international association between Helicobacter pylori infection gastric cancer The EUROGAST Study Group Lancet 1993 341 8857 1359 62 10.1016/0140-6736(93)90938-D
- Ekbom A Helmick C Zack M Adami HO Ulcerative colitis and colorectal cancer. A population-based study N Engl J Med 1990 323 18 1228 33 10.1056/NEJM199011013231802
- Eaden JA Abrams KR Mayberry JF The risk of colorectal cancer in ulcerative colitis: a meta-analysis Gut 2001 48 4 526 35 10.1136/gut.48.4.526
- Ekbom A Helmick C Zack M Adami HO Increased risk of large-bowel cancer in Crohn’s disease with colonic involvement Lancet 1990 336 8711 357 9 10.1016/0140-6736(90)91889-I
- Choi PM Zelig MP Similarity of colorectal cancer in Crohn’s disease and ulcerative colitis: implications for carcinogenesis and prevention Gut 1994 35 7 950 4 10.1136/gut.35.7.950
- Doll R Hill AB Lung cancer and other causes of death in relation to smoking; a second report on the mortality of British doctors Br Med J 1956 2 5001 1071 81 10.1136/bmj.2.5001.1071
- Correa P Pickle LW Fontham E Lin Y Haenszel W Passive smoking and lung cancer Lancet 1983 2 8350 595 7 10.1016/S0140-6736(83)90680-3
- Doll R Mortality from lung cancer in asbestos workers 1955 Br J Ind Med 1993 50 6 485 90 10.1136/oem.50.6.485
- Hughes JM Weill H Asbestosis as a precursor of asbestos related lung cancer: results of a prospective mortality study Br J Ind Med 1991 48 4 229 33 10.1136/oem.48.4.229
- Khansari N Shakiba Y Mahmoudi M Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer Recent Pat Inflamm Allergy Drug Discov 2009 3 1 73 80 10.2174/187221309787158371
- Reuter S Gupta SC Chaturvedi MM Aggarwal BB Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med 2010 49 11 1603 16 10.1016/j.freeradbiomed.2010.09.006
- Wang K Karin M Tumor-Elicited Inflammation and Colorectal Cancer Adv Cancer Res 2015 128 173 96 10.1016/bs.acr.2015.04.014
- Elinav E Nowarski R Thaiss CA Hu B Jin C Flavell RA Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms Nat Rev Cancer 2013 13 11 759 71 10.1038/nrc3611
- DiDonato JA Mercurio F Karin M NF-kappaB and the link between inflammation and cancer Immunol Rev 2012 246 1 379 400 10.1111/j.1600-065X.2012.01099.x
- Yu H Kortylewski M Pardoll D Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment Nat Rev Immunol 2007 7 1 41 51 10.1038/nri1995
- He G Karin M NF-kappaB and STAT3 – key players in liver inflammation and cancer Cell Res 2011 21 1 159 68 10.1038/cr.2010.183
- Grivennikov SI Karin M Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer Cytokine Growth Factor Rev 2010 21 1 11 9 10.1016/j.cytogfr.2009.11.005
- Hayden MS Ghosh S Signaling to NF-kappaB Genes Dev 2004 18 18 2195 224 10.1101/gad.1228704
- Ghosh S Karin M Missing pieces in the NF-kappaB puzzle Cell 2002 109 Suppl: S81–96 10.1016/S0092-8674(02)00703-1
- Karin M Greten FR NF-kappaB: linking inflammation and immunity to cancer development and progression Nat Rev Immunol 2005 5 10 749 59 10.1038/nri1703
- Cho ML Kang JW Moon YM Nam HJ Jhun JY Heo SB STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice J Immunol 2006 176 9 5652 61 10.4049/jimmunol.176.9.5652
- Oppmann B Lesley R Blom B Timans JC Xu Y Hunte B Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity 2000 13 5 715 25 10.1016/S1074-7613(00)00070-4
- Singh A Singh A Bauer SJ Wheeler DL Havighurst TC Kim K Genetic deletion of TNFalpha inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKCepsilon transgenic mice via inhibition of cell survival signals Carcinogenesis 2016 37 1 72 80 10.1093/carcin/bgv162
- Moore RJ Owens DM Stamp G Arnott C Burke F East N Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis Nat Med 1999 5 7 828 31 10.1038/10462
- Karin M NF-kappaB and cancer: mechanisms and targets Mol Carcinog 2006 45 6 355 61 10.1002/mc.20217
- Greten FR Eckmann L Greten TF Park JM Li ZW Egan LJ IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer Cell 2004 118 3 285 96 10.1016/j.cell.2004.07.013
-
Stark
GR
Darnell
JE
Jr. The JAK-STAT pathway at twenty Immunity 2012 36 4 503 14 10.1016/j.immuni.2012.03.013 - Yu H Jove R The STATs of cancer—new molecular targets come of age Nat Rev Cancer 2004 4 2 97 105 10.1038/nrc1275
- Rebouissou S Amessou M Couchy G Poussin K Imbeaud S Pilati C Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours Nature 2009 457 7226 200 4 10.1038/nature07475
- Taniguchi K Wu LW Grivennikov SI de Jong PR Lian I Yu FX A gp130-Src-YAP module links inflammation to epithelial regeneration Nature 2015 519 7541 57 62 10.1038/nature14228
- Grivennikov S Karin E Terzic J Mucida D Yu GY Vallabhapurapu S IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer Cancer Cell 2009 15 2 103 13 10.1016/j.ccr.2009.01.001
- Pasparakis M Haase I Nestle FO Mechanisms regulating skin immunity and inflammation Nat Rev Immunol 2014 14 5 289 301 10.1038/nri3646
- Alonso L Fuchs E Stem cells of the skin epithelium Proc Natl Acad Sci U S A 2003 100 Suppl 1 11830 5 10.1073/pnas.1734203100
- Madison KC Barrier function of the skin: “la raison d’etre” of the epidermis J Invest Dermatol 2003 121 2 231 41 10.1046/j.1523-1747.2003.12359.x
- Slominski A Tobin DJ Shibahara S Wortsman J Melanin pigmentation in mammalian skin and its hormonal regulation Physiol Rev 2004 84 4 1155 228 10.1152/physrev.00044.2003
- Hearing VJ Biogenesis of pigment granules: a sensitive way to regulate melanocyte function J Dermatol Sci 2005 37 1 3 14 10.1016/j.jdermsci.2004.08.014
- Merad M Ginhoux F Collin M Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells Nat Rev Immunol 2008 8 12 935 47 10.1038/nri2455
- Medler TR Coussens LM Duality of the immune response in cancer: lessons learned from skin J Invest Dermatol 2014 134 e1 E23 8 10.1038/skinbio.2014.5
- Gottlieb AB Chamian F Masud S Cardinale I Abello MV Lowes MA TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques J Immunol 2005 175 4 2721 9 10.4049/jimmunol.175.4.2721
- Gordon KB Langley RG Leonardi C Toth D Menter MA Kang S Clinical response to adalimumab treatment in patients with moderate to severe psoriasis: double-blind, randomized controlled trial and open-label extension study J Am Acad Dermatol 2006 55 4 598 606 10.1016/j.jaad.2006.05.027
- Arnott CH Scott KA Moore RJ Hewer A Phillips DH Parker P Tumour necrosis factor-alpha mediates tumour promotion via a PKC alpha- and AP-1-dependent pathway Oncogene 2002 21 31 4728 38 10.1038/sj.onc.1205588
- Shao Y Le K Cheng H Aplin AE NF-kappaB Regulation of c-FLIP Promotes TNFalpha-Mediated RAF Inhibitor Resistance in Melanoma J Invest Dermatol 2015 135 7 1839 48 10.1038/jid.2015.91
- Arnott CH Scott KA Moore RJ Robinson SC Thompson RG Balkwill FR Expression of both TNF-alpha receptor subtypes is essential for optimal skin tumour development Oncogene 2004 23 10 1902 10 10.1038/sj.onc.1207317
- Scott KA Moore RJ Arnott CH East N Thompson RG Scallon BJ An anti-tumor necrosis factor-alpha antibody inhibits the development of experimental skin tumors Mol Cancer Ther 2003 2 5 445 51
- Cataisson C Salcedo R Hakim S Moffitt BA Wright L Yi M IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis The Journal of experimental medicine 2012 209 9 1689 702 10.1084/jem.20101355
- Cataisson C Ohman R Patel G Pearson A Tsien M Jay S Inducible cutaneous inflammation reveals a protumorigenic role for keratinocyte CXCR2 in skin carcinogenesis Cancer research 2009 69 1 319 28 10.1158/0008-5472.CAN-08-2490
- Mann A Breuhahn K Schirmacher P Wilhelmi A Beyer C Rosenau A Up- and down-regulation of granulocyte/macrophage-colony stimulating factor activity in murine skin increase susceptibility to skin carcinogenesis by independent mechanisms Cancer research 2001 61 5 2311 9
- Feldmeyer L Keller M Niklaus G Hohl D Werner S Beer HD The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes Curr Biol 2007 17 13 1140 5 10.1016/j.cub.2007.05.074
- Kupper TS Ballard DW Chua AO McGuire JS Flood PM Horowitz MC Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1 The Journal of experimental medicine 1986 164 6 2095 100 10.1084/jem.164.6.2095
- Bos JL ras oncogenes in human cancer: a review Cancer research 1989 49 17 4682 9
- Lederle W Depner S Schnur S Obermueller E Catone N Just A IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines Int J Cancer 2011 128 12 2803 14 10.1002/ijc.25621
- Gu D Fan Q Zhang X Xie J A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis J Biol Chem 2012 287 45 38356 66 10.1074/jbc.M112.377382
- Chan KS Sano S Kiguchi K Anders J Komazawa N Takeda J Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis J Clin Invest 2004 114 5 720 8 10.1172/JCI200421032
- Kim DJ Angel JM Sano S DiGiovanni J Constitutive activation and targeted disruption of signal transducer and activator of transcription 3 (Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis Oncogene 2009 28 7 950 60 10.1038/onc.2008.453
- Kim DJ Kataoka K Sano S Connolly K Kiguchi K DiGiovanni J Targeted disruption of Bcl-xL in mouse keratinocytes inhibits both UVB- and chemically induced skin carcinogenesis Mol Carcinog 2009 48 10 873 85 10.1002/mc.20527
- Allen SM Florell SR Hanks AN Alexander A Diedrich MJ Altieri DC Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression Cancer research 2003 63 3 567 72
- Fofaria NM Srivastava SK Critical role of STAT3 in melanoma metastasis through anoikis resistance Oncotarget 2014 5 16 7051 64 10.18632/oncotarget.2251
- Na YR Lee JS Lee SJ Seok SH Interleukin-6-induced Twist and N-cadherin enhance melanoma cell metastasis Melanoma Res 2013 23 6 434 43 10.1097/CMR.0000000000000021
- Trinchieri G Pflanz S Kastelein RA The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses Immunity 2003 19 5 641 4 10.1016/S1074-7613(03)00296-6
- Vignali DA Kuchroo VK IL-12 family cytokines: immunological playmakers Nature immunology 2012 13 8 722 8 10.1038/ni.2366
- Langowski JL Zhang X Wu L Mattson JD Chen T Smith K IL-23 promotes tumour incidence and growth Nature 2006 442 7101 461 5 10.1038/nature04808
- Roses RE Xu S Xu M Koldovsky U Koski G Czerniecki BJ Differential production of IL-23 and IL-12 by myeloid-derived dendritic cells in response to TLR agonists J Immunol 2008 181 7 5120 7 10.4049/jimmunol.181.7.5120
- Carmody RJ Ruan Q Liou HC Chen YH Essential roles of c-Rel in TLR-induced IL-23 p19 gene expression in dendritic cells J Immunol 2007 178 1 186 91 10.4049/jimmunol.178.1.186
- Kortylewski M Xin H Kujawski M Lee H Liu Y Harris T Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment Cancer Cell 2009 15 2 114 23 10.1016/j.ccr.2008.12.018
- Cua DJ Tato CM Innate IL-17-producing cells: the sentinels of the immune system Nat Rev Immunol 2010 10 7 479 89 10.1038/nri2800
- Harrington LE Hatton RD Mangan PR Turner H Murphy TL Murphy KM Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages Nature immunology 2005 6 11 1123 32 10.1038/ni1254
- Park H Li Z Yang XO Chang SH Nurieva R Wang YH A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 Nature immunology 2005 6 11 1133 41 10.1038/ni1261
- Langrish CL Chen Y Blumenschein WM Mattson J Basham B Sedgwick JD IL-23 drives a pathogenic T cell population that induces autoimmune inflammation The Journal of experimental medicine 2005 201 2 233 40 10.1084/jem.20041257
- Wang L Yi T Zhang W Pardoll DM Yu H IL-17 enhances tumor development in carcinogen-induced skin cancer Cancer research 2010 70 24 10112 20 10.1158/0008-5472.CAN-10-0775
- Forcales SV Albini S Giordani L Malecova B Cignolo L Chernov A Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex The EMBO journal 2012 31 2 301 16 10.1038/emboj.2011.391
- Nardinocchi L Sonego G Passarelli F Avitabile S Scarponi C Failla CM Interleukin-17 and interleukin-22 promote tumor progression in human nonmelanoma skin cancer Eur J Immunol 2015 45 3 922 31 10.1002/eji.201445052
- Swann JB Smyth MJ Immune surveillance of tumors J Clin Invest 2007 117 5 1137 46 10.1172/JCI31405
- Schumacher TN Schreiber RD Neoantigens in cancer immunotherapy Science 2015 348 6230 69 74 10.1126/science.aaa4971
- Yusuf N Nasti TH Katiyar SK Jacobs MK Seibert MD Ginsburg AC Antagonistic roles of CD4+ and CD8+ T-cells in 7,12-dimethylbenz(a)anthracene cutaneous carcinogenesis Cancer research 2008 68 10 3924 30 10.1158/0008-5472.CAN-07-3059
- Ikeda H Old LJ Schreiber RD The roles of IFN gamma in protection against tumor development and cancer immunoediting Cytokine Growth Factor Rev 2002 13 2 95 109 10.1016/S1359-6101(01)00038-7
- Dunn GP Bruce AT Ikeda H Old LJ Schreiber RD Cancer immunoediting: from immunosurveillance to tumor escape Nature immunology 2002 3 11 991 8 10.1038/ni1102-991
- Kaplan DH Shankaran V Dighe AS Stockert E Aguet M Old LJ Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice Proc Natl Acad Sci U S A 1998 95 13 7556 61 10.1073/pnas.95.13.7556
- Street SE Cretney E Smyth MJ Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis Blood 2001 97 1 192 7 10.1182/blood.V97.1.192
- Gao Y Yang W Pan M Scully E Girardi M Augenlicht LH Gamma delta T cells provide an early source of interferon gamma in tumor immunity The Journal of experimental medicine 2003 198 3 433 42 10.1084/jem.20030584
- Pardoll DM The blockade of immune checkpoints in cancer immunotherapy Nat Rev Cancer 2012 12 4 252 64 10.1038/nrc3239
- Melero I Berman DM Aznar MA Korman AJ Perez Gracia JL Haanen J Evolving synergistic combinations of targeted immunotherapies to combat cancer Nat Rev Cancer 2015 15 8 457 72 10.1038/nrc3973
- Moore KW de Waal Malefyt R Coffman RL O’Garra A Interleukin-10 and the interleukin-10 receptor Annu Rev Immunol 2001 19 683 765 10.1146/annurev.immunol.19.1.683
- Chaudhry A Samstein RM Treuting P Liang Y Pils MC Heinrich JM Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation Immunity 2011 34 4 566 78 10.1016/j.immuni.2011.03.018
- Loser K Apelt J Voskort M Mohaupt M Balkow S Schwarz T IL-10 controls ultraviolet-induced carcinogenesis in mice J Immunol 2007 179 1 365 71 10.4049/jimmunol.179.1.365
- Josefowicz SZ Lu LF Rudensky AY Regulatory T cells: mechanisms of differentiation and function Annu Rev Immunol 2012 30 531 64 10.1146/annurev.immunol.25.022106.141623
- Vignali DA Collison LW Workman CJ How regulatory T cells work Nat Rev Immunol 2008 8 7 523 32 10.1038/nri2343
- Bettelli E Carrier Y Gao W Korn T Strom TB Oukka M Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells Nature 2006 441 7090 235 8 10.1038/nature04753
- Glick AB The Role of TGFbeta Signaling in Squamous Cell Cancer: Lessons from Mouse Models J Skin Cancer 2012 2012 249063 10.1155/2012/249063
- Wang XJ Greenhalgh DA Bickenbach JR Jiang A Bundman DS Krieg T Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition Proc Natl Acad Sci U S A 1997 94 6 2386 91 10.1073/pnas.94.6.2386
- Go C Li P Wang XJ Blocking transforming growth factor beta signaling in transgenic epidermis accelerates chemical carcinogenesis: a mechanism associated with increased angiogenesis Cancer research 1999 59 12 2861 8
- Lu SL Herrington H Reh D Weber S Bornstein S Wang D Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma Genes Dev 2006 20 10 1331 42 10.1101/gad.1413306
- Derynck R Akhurst RJ Balmain A TGF-beta signaling in tumor suppression and cancer progression Nat Genet 2001 29 2 117 29 10.1038/ng1001-117
- Katsuno Y Lamouille S Derynck R TGF-beta signaling and epithelial-mesenchymal transition in cancer progression Curr Opin Oncol 2013 25 1 76 84 10.1097/CCO.0b013e32835b6371
- Kalluri R Weinberg RA The basics of epithelial-mesenchymal transition J Clin Invest 2009 119 6 1420 8 10.1172/JCI39104
- Gorelik L Flavell RA Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells Nat Med 2001 7 10 1118 22 10.1038/nm1001-1118
- Fridman WH Pages F Sautes-Fridman C Galon J The immune contexture in human tumours: impact on clinical outcome Nat Rev Cancer 2012 12 4 298 306 10.1038/nrc3245
- Whiteside TL What are regulatory T cells (Treg) regulating in cancer and why? Semin Cancer Biol 2012 22 4 327 34 10.1016/j.semcancer.2012.03.004
- Wang K Grivennikov SI Karin M Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases Ann Rheum Dis 2013 72 Suppl 2 ii100 3 10.1136/annrheumdis-2012-202201
- Palladino MA Bahjat FR Theodorakis EA Moldawer LL Anti-TNF-alpha therapies: the next generation Nature reviews Drug discovery 2003 2 9 736 46 10.1038/nrd1175
- Bongartz T Sutton AJ Sweeting MJ Buchan I Matteson EL Montori V Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials Jama 2006 295 19 2275 85 10.1001/jama.295.19.2275
- Kishimoto T IL-6: from its discovery to clinical applications International immunology 2010 22 5 347 52 10.1093/intimm/dxq030
- Burakoff R Barish CF Riff D Pruitt R Chey WY Farraye FA A phase 1/2A trial of STA 5326, an oral interleukin-12/23 inhibitor, in patients with active moderate to severe Crohn’s disease Inflammatory bowel diseases 2006 12 7 558 65 10.1097/01.ibd.0000225337.14356.31
- Sandborn WJ Feagan BG Fedorak RN Scherl E Fleisher MR Katz S A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn’s disease Gastroenterology 2008 135 4 1130 41 10.1053/j.gastro.2008.07.014
- Cottone M Orlando A Renna S Investigational agents for Crohn’s disease Expert opinion on investigational drugs 2010 19 10 1147 59 10.1517/13543784.2010.510513
- Terzic J Grivennikov S Karin E Karin M Inflammation and colon cancer Gastroenterology 2010 138 6 2101 14 e5
- Miossec P Kolls JK Targeting IL-17 and TH17 cells in chronic inflammation Nature reviews Drug discovery 2012 11 10 763 76 10.1038/nrd3794
- Lebwohl M Strober B Menter A Gordon K Weglowska J Puig L Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis N Engl J Med 2015 373 14 1318 28 10.1056/NEJMoa1503824
- Pico de Coana Y Choudhury A Kiessling R Checkpoint blockade for cancer therapy: revitalizing a suppressed immune system Trends Mol Med 2015 21 8 482 91 10.1016/j.molmed.2015.05.005
DOI: https://doi.org/10.5334/1750-2187-11-2 | Journal eISSN: 1750-2187
Language: English
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Published on: May 5, 2016
Published by: Danny N. Dhanasekaran
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© 2016 Lihua Tang, Kepeng Wang, published by Danny N. Dhanasekaran
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