Successful Steroid Therapy on Extrahepatic Cholestasis

Cholestasis is a pathological jaundice that mostly caused by biliary atresia. Although Kasai surgery is the standard therapy, new developments in adjunctive therapies are still needed to improve outcomes. A 2-month-old baby boy presented with jaundice since 1 week of age, followed by abdominal distention and pale stools. Examination showed hepatomegaly, anaemia, elevated bilirubin, elevated liver enzyme, and reactive Rubella IgG. Liver biopsy indicates extrahepatic cholestasis. The patient received ursodeoxycholic acid and methylprednisolone. After eight weeks, his stool darkened, jaundice resolved, and liver function normalized. This case demonstrates the successful treatment of cholestasis suggesting biliary atresia with steroids.