Rapid response to infliximab in a patient with recalcitrant pyoderma gangrenosum and rheumatoid arthritis

Pyoderma gangrenosum (PG) is a rare, chronic, recurrent cutaneous ulcerative disease. The pathogenesis of PG remains unknown but the association of this condition with inflammatory bowel disease and rheumatoid arthritis makes it likely that TNF-α plays an integral role in the development of the disease, with TNF-α inhibitors having been reported as therapy in resistant cases. Here-in we report a case of resistant pyoderma gangrenosum in a patient with rheumatoid arthritis which showed rapid response to infliximab.