Adalimumab in severe hidradenitis suppurativa – a case report of a novel experience

Hidradenitis suppurativa (HS) is a chronic inflammatory disabling disorder which affects apocrine gland bearing skin, characterized by discharging sinuses, nodules and abscesses that relentlessly progress and frequently cause scarring, contractures and immobility. Exact pathogenesis of the HS remains incompletely understood. Current theories suggest follicular obstruction and rupture leading to subsequent inflammation. Therapeutic options are often unsatisfactory in severe cases. However, biologics have shown promising results recently and tumor necrosis factor - α (TNF-α) inhibitors have been reported as effective therapy in severe cases. Herein we report a case of severe recalcitrant HS which improved with adalimumab.