Effectiveness and adverse effects of ciclosporin in patients with psoriasis

Objectives: To find out effectiveness and adverse effects of ciclosporin in patients with psoriasis.

Methodology: It was a prospective study designed in accordance with established guidelines and the dose of ciclosporin was 3 mg/kg/ day. Patients were reviewed at 2, 4 and 8 weeks and data collected included PASI score and adverse events of cyclosporine. Patient’s response to the treatment was rated at the end of the study.

Results: A total of 21 subjects (mean age 48) were studied and reduction in mean PASI score was 50% and 67% at 4 weeks and at 8 weeks respectively which were statistically significant. At the end of the study majority of patients (89%) rated the drug as 'good' or 'very good'. Adverse events were reported in 45 % of patients and they reflected known side effect profile of ciclosporin

Conclusion: Ciclosporin can improve chronic plaque psoriasis successfully within short period of time and no serious side effects were reported.