Clinico-pathological correlations of childhood glomerular disease in Eastern India
Abstract
Background: Histopathological examination of renal biopsy has an important role in establishing glomerular disease in children.
Objective: To describe and correlate the types of glomerular diseases reported in native kidney biopsy and their clinical presentations.
Method: This retrospective and descriptive study was conducted from December 2009 to December 2013 at the Department of Paediatrics, SVPPGIP & SCB Medical College, Cuttack, Odisha, India. A total of 142 renal biopsies were performed in 140 children aged 6 months to 14 years. Their demographic data, indication for renal biopsy and histological diagnosis were analysed and correlated with clinical presentations in the study.
Results: In 136 (97.1%) of 140 children, the renal histopathology revealed glomerular diseases. The male to female ratio was 1.5:1. The most frequent types of biopsy-proven renal diseases were: Minimal Change Disease 47 (33.5%), Focal Segmental Glomerulosclerosis 29 (20.7%), IgA nephropathy 21 (15%), Lupus nephritis 11 (7.8%) and Post-streptococcal glomerulonephritis 8 (5.7%). Nephrotic syndrome was the most common glomerular disease 106 (77.9%).
Conclusions: In our study, Minimal Change Disease was the most common biopsy proven glomerular disease and nephrotic syndrome was the most frequent clinical presentation. The best clinico-pathological correlation was seen with lupus nephritis cases.
Sri Lanka Journal of Child Health, 2015; 44(1): 31-37
© 2015 Pawan Pradeep Mutalik, Subal Kumar Pradhan, Bikrant Kumar Prusty, Kedar Das, Saroj Kumar Satapathy, published by Sri Lanka College of Paediatricians
This work is licensed under the Creative Commons License.