Anaesthetic management of a case of Alkaptonuria for Total knee arthroplasty.
Abstract
Alkaptonuria, is a rare autosomal recessive disorder of tyrosine metabolism caused by a deficiency of homogentisate 1,2dioxygenase. It results in accumulation of homogentisic acid in spine and large joints and cardiac valves. It also involves respiratory, airway, genitourinary, cutaneous and ocular systems. Administering spinal anaesthesia is extremely challenging in these cases. We report a case of a 66yr old male alkaptonuric ochronosis with symptoms of ankylosing spondylitis, hypertension and obstructive sleep apnoea for total knee replacement successfully managed intraoperatively with subarachnoid block after marking the interspinous space with ultrasound.
© 2015 Anbarasan Ardhanari, Vinaya Kumar V Seetharam, Muralidhar Thondebhavi Subbaramaiah, MS Kumaraswamy, published by College of Anaesthesiologists of Sri Lanka
This work is licensed under the Creative Commons License.