Evaluation of intrathecal neostigmine in different doses added to bupivacaine for postoperative analgesia
By: Mubasher Ahmad Bhat, Mohamad Ommid, Arun Kumar Gupta, Zahoor Ahmad Shah, Faisal Ismail, Gousia Nisa, Sheeba Nazir and Shigufta Qazi
Open Access
|Mar 2011Abstract
Background: Neuraxial administration of neostigmine alongwith local anaesthetics improves the quality of intraoperative analgesia and also provides postoperative pain relief for longer duration. The present study was conducted to study the efficacy and safety of intrathecal neostigmine with bupivacaine in two different doses.
Methods: Ninety patients of ASA I and II undergoing lower abdominal and lower limb surgeries under spinal anaesthesia were enrolled and divided into 3 groups of 30 each. Group A: bupivacaine control group, Group B: bupivacaine plus 50mcg neostigmine and Group C; bupivacaine plus 150mcg neostigmine. Haemodynamic parameters, sensory and motor characteristics along with side effects were recorded. The post operative pain assessment was done by visual analogue scale score at hourly intervals for the first four hours, then two hourly intervals for the next 6 hours and thereafter at 24 hours. It was scaled from a score of 0 meaning no pain to a score of 100 meaning worst pain perceived. Time of two segment regression of sensory blockade and total duration of motor block was significantly prolonged in group B and C as compared to the control group.
Results: The mean total duration for analgesia was significantly prolonged in Group B (340±8.36) and Group C (700±8.65) when compared to group A (263.30±7.57) (p<0.05).
Conclusion: We conclude that intrathecal neostigmine results in effective postoperative analgesia prolonging sensory and motor block without hemodynamic and respiratory depression in the intra and postoperative period.
Key words: Bupivacaine; Neostigmine; Spinal Anaesthesia
DOI: 10.4038/slja.v19i1.1881
Sri Lankan Journal of Anaesthesiology Vol.19(1) 2011 pp.33-38
Methods: Ninety patients of ASA I and II undergoing lower abdominal and lower limb surgeries under spinal anaesthesia were enrolled and divided into 3 groups of 30 each. Group A: bupivacaine control group, Group B: bupivacaine plus 50mcg neostigmine and Group C; bupivacaine plus 150mcg neostigmine. Haemodynamic parameters, sensory and motor characteristics along with side effects were recorded. The post operative pain assessment was done by visual analogue scale score at hourly intervals for the first four hours, then two hourly intervals for the next 6 hours and thereafter at 24 hours. It was scaled from a score of 0 meaning no pain to a score of 100 meaning worst pain perceived. Time of two segment regression of sensory blockade and total duration of motor block was significantly prolonged in group B and C as compared to the control group.
Results: The mean total duration for analgesia was significantly prolonged in Group B (340±8.36) and Group C (700±8.65) when compared to group A (263.30±7.57) (p<0.05).
Conclusion: We conclude that intrathecal neostigmine results in effective postoperative analgesia prolonging sensory and motor block without hemodynamic and respiratory depression in the intra and postoperative period.
Key words: Bupivacaine; Neostigmine; Spinal Anaesthesia
DOI: 10.4038/slja.v19i1.1881
Sri Lankan Journal of Anaesthesiology Vol.19(1) 2011 pp.33-38
DOI: https://doi.org/10.4038/slja.v19i1.1881 | Journal eISSN: 2279-1965
Language: English
Page range: 33 - 38
Published on: Mar 14, 2011
Published by: College of Anaesthesiologists of Sri Lanka
In partnership with: Paradigm Publishing Services
Keywords:
© 2011 Mubasher Ahmad Bhat, Mohamad Ommid, Arun Kumar Gupta, Zahoor Ahmad Shah, Faisal Ismail, Gousia Nisa, Sheeba Nazir, Shigufta Qazi, published by College of Anaesthesiologists of Sri Lanka
This work is licensed under the Creative Commons License.