Pregnancy-Associated Exacerbation of Darier’s Disease: A Rare Obstetric Case Report

Background: Darier’s disease is a rare inherited disorder of keratinisation. Reports describing its behaviour and clinical impact during pregnancy are limited, particularly in cases with extensive vulval involvement.

Case: A 39-year-old multiparous woman presented at 32 weeks’ gestation with a widespread exacerbation of previously diagnosed Darier’s disease, involving the vulva, groin, lower abdomen, submammary region, neck, and face. Severe vulval fissuring and reduced skin elasticity were noted. Obstetric evaluation demonstrated normal fetal growth. The patient was managed conservatively with topical therapy under multidisciplinary care.

Conclusion: Although rare, Darier’s disease may worsen during pregnancy and present unique obstetric and perioperative challenges. Early recognition and coordinated management are essential to minimise morbidity and guide delivery planning.